Fig. 5

Effect of BSTL on mitochondrial biogenesis and dysfunction in vivo. A TEM of mitochondria from different groups (× 50 000). Scale bar, 1 µm. Arrow means representative pathological changes. B Quantitation of mtDNA content in the kidneys of mice from different groups. C Quantitation of mitochondrial respiratory chain complexes I, III, and IV activities in the kidneys of mice. D Representative western blots and quantitative assessment of PGC-1α, MFN2, DRP1, and TFAM in the kidneys of mice. ^*P < 0.05 vs. con; ^**P < 0.01 vs. con; ^#P < 0.05 vs. db/db; ^##P < 0.01 vs. db/db. con, the control mice; db/db, db/db mice; db/db + B, db/db mice treated with BSTL