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Fig. 1 | Chinese Medicine

Fig. 1

From: A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example

Fig. 1

Comparison of the new strategy with the classical scheme. Gut microbial- and hepatic-biotransformation analyses are performed before the target prediction of herbal products. Next, the ASIV targets after biotransformation are intersected with that of ICH. Then, GO and KEGG analyses enrich the related biological processes. At last, molecular docking, molecular dynamics simulation, and cell and animal experiments confirm the transformation-added targets and pathways. ASIV Astragaloside IV, ICH intracerebral hemorrhage. Solid circle: intersected; hollow circle: not intersected

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Chinese Medicine

ISSN: 1749-8546

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