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Fig. 2 | Chinese Medicine

Fig. 2

From: A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example

Fig. 2

Microbial and hepatic biotransformation of ASIV. ASIV is transformed by gut microbiota to form Cyc B, Bra B, CA, CA-2H, and iso-CA. The microbiota-transformed products are infused into the liver. Then CA is partly converted into CA-2H and iso-CA. The bile duct system exerts Cyc B, Bra B, and ASIV. Only ASIV, CA, and iso-CA are detectable in the bloodstream. ASIV Astragaloside IV, CA cycloastragenol; iso-CA 3-epi-cycloastragenol, Bra B 6-O-β-d-glucopyranosyl, Cyc B 3-O-β-d-xylopyranosyl-cycloastragenol; CA-2H dehydrogenated to 20R, 24S-epoxy-6α, 16β, 25-tyihydroxy-9-cycloartan-3-one

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Chinese Medicine

ISSN: 1749-8546

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