A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example

Table 1 The predicted ADME properties, drug-likeness, pharmacokinetic, and physicochemical properties of Astragaloside IV and its derivates

Compounds	MW	Lipophilicity	Water solubility	GI absorption	BBB permeability	Bioavailability score	Synthetic accessibility	DL
ASIV	784.97	4.22	Moderate	Low	–	0.17	9.73	No
CA	490.72	3.97	Moderate	High	+	0.55	7.28	Yes
Iso-CA	490.72	4.28	Moderate	High	+	0.55	7.28	Yes

MW molecular weight, GI gastrointestinal, BBB blood–brain barrier, DL drug-likeness, ASIV astragaloside IV, CA iso-CA CA: cycloastragenol, iso-CA 3-epi-cycloastragenol

ISSN: 1749-8546