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Table 2 The associations of the core genes to ICH and the herbal products

From: A novel microbial and hepatic biotransformation-integrated network pharmacology strategy explores the therapeutic mechanisms of bioactive herbal products in neurological diseases: the effects of Astragaloside IV on intracerebral hemorrhage as an example

Target

Compound

Relations to herbal products

Relations to ICH

Swissa target prediction

Pharmb mapper

ScEA

Gened cards

OM IM

DisGeeNET

GAD

AKT3

CA

26/0

–

–

19.046

–

–

–

ALK

CA

42/0

–

–

14.515

–

–

–

CDC42

CA

–

2.797

–

10.492

–

–

–

CDK6

Iso-CA

–

2.499

–

12.655

–

–

–

CREBBP

Iso-CA

7/0

–

–

12.566

–

–

–

CSF1R

CA

50/0

–

–

18.709

–

–

–

 

Iso-CA

63/0

–

–

    

HGF

Iso-CA

–

2.996

–

10.667

–

–

–

HRAS

CA

–

2.348

–

19.016

–

–

–

PIK3R1

CA

–

3.081

–

14.633

–

–

–

 

Iso-CA

–

4.418

–

    

PTK2

CA

–

2.348

–

11.550

–

–

–

RET

Iso-CA

15/0

–

–

10.987

Yes

0.1

–

STAT1

CA

–

2.567

–

11.556

–

–

–

TNF

CA

4/0

–

–

30.716

–

–

Yes

  1. aThe number of hit known actives (3D/2D) in the SwissTargetPrediction database
  2. bThe fit scores in the PharmMapper database
  3. cThe Max Tc in the SEA database
  4. dThe relevance scores in the GeneCards database
  5. eThe disease-gene association scores in the DisGeNET database