Fig. 7

MON inhibited cartilage matrix degradation in DMM mice. A, B Immunofluorescence staining of Collagen II and MMP13 were performed respectively in mice knee joints at 56 days after MON treatment. C, D The relative quantification analysis of Collagen II positive area and MMP13 positive cells. E–G Western blot analysis and relative quantification showing the expression levels of cartilage matrix degradation related proteins (MMP3, MMP13, Collagen II and SOX9) in DMM mice at 56 days after MON treatment. All experiments were performed in triplicated and data were presented as the mean ± SD, n = 3 per group. *P < 0. 05, **P < 0. 01