Fig. 9

The GO classification and KEGG pathway analysis of differentially expressed genes in A549 cells treated with CAE and TGF-β1. A DEGs cluster analysis diagram with three replicate samples in each group. Each column represents a sample, and each row represents a gene. Red means up regulation while blue means down regulation. The above is a dendrogram of sample clustering. The closer the branches of the two samples are, the closer the expression patterns of all differential genes in the two samples are. On the left is a dendrogram of gene clusters and the closer the two gene branches are, the closer their expression levels are. B DEGs GO enrichment column. The abscissa is the P value after -log10 processing. The three major categories of GO are represented by different colored columns (green represents biological processes, blue represents molecular functions, and red represents cellular components). C Bubble chart of KEGG enrichment of DEGs. The abscissa represents the P value corresponding to the pathway. The size of the rich factor is represented by the color of the dots. The larger the value, the closer the color is to red. The number of DEGs contained in each pathway is represented by the size of the scattered dots. P value refers to the significance of pathway enrichment, the value range is [0, 1], the closer to zero, the more significant the enrichment. D Part of pathways and differentially expressed genes on them