Fig. 1

Effects of YXT and its selected herbal components on Aβ aggregation and cytotoxicity. A ThT assay was used to measure the aggregation of 5 µM Aβ42 in the absence (Con) or presence of (A) aqueous (Aq) or (B) ethanol (EtOH) extracts of YXT (left panel) and selected YXT herbal components (right panel). Data is illustrated in blue (YXT), dark red (PA), orange (PS), yellow (RA), green (RC), and beige (RP). A WST assay was used to assess Aβ42-induced cytotoxicity in primary cortical neurons cultured in the absence (Con) or presence of aqueous (left) or ethanol (right) extracts of YXT and its selected herbal components (C). Treatment was performed with extracts of RP at 10 μg/mL, and 100 μg/ mL for all the remaining herbs. 100% Aβ-induced cell death was defined as the loss of viable cells upon treatment with 5 µM Aβ42 for 48 h. *P < 0.05 (ANOVA); n = 6