From: Multi-target regulatory mechanism of Yang Xin Tang − a traditional Chinese medicine against dementia
Promoter | % Luciferase activities changesa,b | |||
---|---|---|---|---|
Aqueous extract | Ethanol extract | |||
YXT | Positive control | YXT | Positive control | |
Neurogenesis | ||||
AP-1-RE | − 5.6 ± 0.1 | 66.3 ± 2.1c | 36.8 ± 4.2c | 118.7 ± 0.5c |
CRE | − 1.7 ± 2.6 | 96.9 ± 2.6c | 15.6 ± 5.0c | 153.2 ± 0.1c |
STAT3-RE | − 8.3 ± 1.9 | 56.7 ± 5.3c | − 11.8 ± 1.2 | 326.7 ± 2.9c |
Neuronal cell survival | ||||
LILRE | 6.4 ± 1.4 | 30.8 ± 2.5c | − 3.1 ± 0.1 | 211.4 ± 2.7c |
p53-RE | − 6.9 ± 1.4 | 166.9 ± 5.2c | − 49.1 ± 0.1# | 101.5 ± 7.8c |
TARE | − 11.7 ± 0.4 | 3612.2 ± 13.6c | − 23.2 ± 1.1# | 2961.8 ± 57.6c |
Aβ and NFT formation | ||||
ISRE | − 4.2 ± 0.1 | 2504.0 ± 47.2c | 4.1 ± 8.0 | 2753.9 ± 431.6c |
GAS | 3.4 ± 2.5 | 29.8 ± 7.1c | − 17.1 ± 5.0d | 18.6 ± 4.3c |
NFκB-RE | − 14.4 ± 1.8d | 187.2 ± 8.5c | − 11.0 ± 0.5 | 149.8 ± 2.5c |