Fig. 3

Curdione inhibited tumor formation in colorectal cancer xenograft mice. a–c. After 22 days of drug administration (50 mg/kg, 100 mg/kg, 200 mg/kg curdione, dissolved in 10% DMSO and 5 mg/kg oxaliplatin), xenograft mice were dissected, and tumor mass and volume were monitored. (6 xenograft mice in each group) d–h. Tumor tissues of xenograft mice in the model group, curdione low-dose, medium-dose, and high-dose groups, and oxaliplatin-positive group were subjected to hematoxylin–eosin staining. Morphological changes in tumor cell arrangement density, tumor cytoplasm, and nuclei were observed. Values are expressed as the mean ± SD of three independent experiments. (n = 3) ^*P < 0.05, ^**P < 0.01, ^***P < 0.001 vs. control group