Fig. 5
From: Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer
Curdione promoted the expression of METTL14 and YTHDF2 and reduced the expression of SLC7A11, SLC3A2, HOXA13, and GPX4. Mice were administered with L-CUR (50 mg/kg), M-CUR (100 mg/kg), and H-CUR (200 mg/kg) for 22 days. a–j. The protein levels of METTL3, METTL4, METTL14, YTHDF2, SLC7A11, SLC3A2, HOXA13, and GPX4 in CRC xenograft mice were measured by Western blotting. Values are expressed as the mean ± SD of three independent experiments. (n = 3) *P < 0.05, **P < 0.01, ***P < 0.001 vs. control group