Fig. 6
From: Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer
Curdione promoted the expression of METTL14, YTHDF2, and PTGS2 and reduced the expression of SLC7A11, SLC3A2, HOXA13, and GPX4. Mice were administered with L-CUR (50 mg/kg), M-CUR (100 mg/kg), and H-CUR (200 mg/kg) for 22 days. a–i. The mRNA levels of METTL3, METTL4, METTL14, SLC3A2, SLC7A11, HOXA13, YTHDF2, GPX4, and PTGS2 in CRC tissues were measured by qRT-PCR. Values are expressed as the mean ± SD of three independent experiments. (n = 3) *P < 0.05, **P < 0.01, ***P < 0.001 vs. control group