Fig. 8
From: Curdione induces ferroptosis mediated by m6A methylation via METTL14 and YTHDF2 in colorectal cancer
Curdione regulated ferroptosis in colorectal cancer via N6-methyladenosine. Curdione upregulated the methylation transferase METTL14, which increased m6A modification in SLC7A11 and SLC3A2 mRNAs. The m6A reader YTHDF2 then promoted the degradation of SLC7A11 and SLC3A2 mRNAs in a m6A-dependent manner, reducing their stability, which triggered reactive oxygen species accumulation and ultimately led to CRC ferroptosis