Table 4 The MGF SA affect the differential metabolites of RAW264.7 inflammatory cells metabolism

HMDB0012452

All-trans-18-Hydroxyretinoic acid

C₂₀H₂₈O₃

15.86

[M+H]⁺

0.0007

0.0000

1.41

Up

Retinol metabolism

HMDB0001343

Mevalonic acid-5P

C₆H₁₃O₇P

7.73

[M+H₂O+H]⁺

0.0002

0.0014

1.45

Up

Terpenoid backbone biosynthesis

HMDB0000291

Vanillylmandelic acid

C₉H₁₀O₅

1.55

[M+C₃H₄O₂+H]⁺

0.0001

0.0012

1.40

Down

Tyrosine metabolism

HMDB0060651

2-Hydroxycarbamazepine

C₁₅H₁₂N₂O₂

5.37

[M+CO₂+H]⁺

0.0000

0.0001

1.42

Up

Drug metabolism—cytochrome P450

HMDB0000870

Histamine

C₅H₉N₃

0.77

[M+H]⁺

0.0004

0.0000

1.42

Up

Histidine metabolism

HMDB0029751

Naphthalene

C₁₀H₈

7.56

[M]⁺

0.0002

0.0000

1.59

Down

Metabolism of xenobiotics by cytochrome P450

HMDB0000014

Deoxycytidine

C₉H₁₃N₃O₄

2.36

[M(C13)+2H]²⁺

0.0003

0.0000

1.22

Down

Pyrimidine metabolism

HMDB0000214

Ornithine

C₅H₁₂N₂O₂

0.92

[M+NH₃+H]⁺

0.0002

0.0000

1.26

Down

Arginine biosynthesis; arginine and proline metabolism; glutathione metabolism

HMDB0000159

l-Phenylalanine

C₉H₁₁NO₂

1.50

[M−HCOOH+H]⁺

0.0001

0.0037

1.31

Down

Phenylalanine metabolism; aminoacyl-tRNA biosynthesis

HMDB0000904

Citrulline

C₆H₁₃N₃O₃

0.91

[M−HCOOH+H]⁺

0.0000

0.0000

1.23

Down

Arginine biosynthesis

HMDB0000034

Adenine

C₅H₅N₅

0.95

[M+H]⁺

0.0001

0.0003

1.39

Down

Purine metabolism

HMDB0000510

Aminoadipic acid

C₆H₁₁NO₄

1.47

[M−H₂O+H]⁺

0.0002

0.0122

1.37

Down

Lysine degradation

HMDB0242149

Xylitol

C₅H₁₂O₅

0.91

[M]⁺

0.0004

0.0395

1.38

Down

Pentose and glucuronate interconversions

HMDB0000517

l-Arginine

C₆H₁₄N₄O₂

0.89

[M−NH₃+H]⁺

0.0000

0.0000

1.23

Down

Arginine biosynthesis; Arginine and proline metabolism; Aminoacyl-tRNA biosynthesis

HMDB0001123

2-Aminobenzoic acid

C₇H₇NO₂

0.87

[M+Na]⁺

0.0006

0.0016

1.25

Down

Tryptophan metabolism

HMDB0060389

4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one

C₁₀H₁₁NO₃

6.29

[M-NH₃+H]⁺

0.0001

0.0002

1.21

down

Drug metabolism—cytochrome P450

HMDB0000175

Inosinic acid

C₁₀H₁₃N₄O₈P

3.67

[M+H+Na]²⁺

0.0000

0.0011

1.30

Up

Purine metabolism

HMDB0004224

N(omega)-hydroxyarginine

C₆H₁₄N₄O₃

0.80

[M+H]⁺

0.0004

0.0452

1.21

Up

Arginine and proline metabolism

HMDB0000763

5-Hydroxyindoleacetic acid

C₁₀H₉NO₃

5.08

[M+H]⁺

0.0001

0.0000

1.23

Down

Tryptophan metabolism

HMDB0000245

Porphobilinogen

C₁₀H₁₄N₂O₄

0.93

[M+H₂O+H]⁺

0.0002

0.0002

1.30

Down

Porphyrin and chlorophyll metabolism

HMDB0000050

Adenosine

C₁₀H₁₃N₅O₄

1.17

[M+H]⁺

0.0000

0.0000

1.34

Up

Purine metabolism

HMDB0001049

gamma-Glutamylcysteine

C₈H₁₄N₂O₅S

7.55

[M+H₂O+H]⁺

0.0006

0.0001

1.23

Down

Glutathione metabolism

HMDB0000235

Thiamine

C₁₂H₁₇N₄OS

1.27

[M+Na]⁺

0.0001

0.0004

1.23

Up

Thiamine metabolism

HMDB0001517

AICAR

C₉H₁₅N₄O₈P

0.92

[M−HCOOH+H]⁺

0.0014

0.0001

1.26

Down

Purine metabolism

HMDB0001198

Leukotriene C4

C₃₀H₄₇N₃O₉S

2.01

[M(C13)+2H]²⁺

0.0008

0.0000

1.22

Down

Arachidonic acid metabolism

HMDB0000163

d-Maltose

C₁₂H₂₂O₁₁

0.92

[M+Na]⁺

0.0000

0.0000

1.24

Down

Starch and sucrose metabolism; Starch and sucrose metabolism

HMDB0000961

Farnesyl pyrophosphate

C₁₅H₂₈O₇P₂

9.82

[M+H₂O+H]⁺

0.0001

0.0000

1.20

Down

Terpenoid backbone biosynthesis; Steroid biosynthesis

HMDB0001993

7a-Hydroxy-cholestene-3-one

C₂₇H₄₄O₂

18.72

[M+H]⁺

0.0002

0.0026

1.37

Down

Primary bile acid biosynthesis

HMDB0002103

27-Hydroxycholesterol

C₂₇H₄₆O₂

15.19

[M+HCOONa]⁺

0.0019

0.0000

1.20

Down

Primary bile acid biosynthesis