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Table 3 PK parameters of 23 potential pharmacodynamic substances in the MG and MPS groups

From: Regulation of polysaccharide in Wu‐tou decoction on intestinal microflora and pharmacokinetics of small molecular compounds in AIA rats

Component name

Group

t 1/2(h)

T max(h)

C max(ng/mL)

AUC 0-t(ng/ml*h)

AUC 0-∞(ng/ml*h)

Source

Benzoylaconine

MG

7.430 ± 5.148

0.125 ± 0.072

0.548 ± 0.178

0.764 ± 0.082

1.015 ± 0.158

ZCW

MPS

3.875 ± 1.842

0.083 ± 0.001

0.720 ± 0.116

1.064 ± 0.136

1.202 ± 0.128

Benzoylmesaconitine

MG

3.530 ± 0.873

0.139 ± 0.079

14.305 ± 3.689

21.413 ± 1.140

23.447 ± 1.422

ZCW

MPS

1.723 ± 0.296

0.083 ± 0.001

15.899 ± 4.818

25.368 ± 7.147

25.465 ± 7.145

Benzoylhypaconine

MG

3.938 ± 0.322

0.083 ± 0.001

0.467 ± 0.108

1.018 ± 0.049

1.123 ± 0.062

ZCW

MPS

4.742 ± 0.904

0.083 ± 0.001

0.861 ± 0.160*

1.394 ± 0.255

1.604 ± 0.229*

Talatizamine

MG

6.242 ± 1.838

0.417 ± 0.276

3.376 ± 0.595

21.996 ± 1.581

30.766 ± 4.871

ZCW

MPS

5.163 ± 1.483

0.292 ± 0.093

3.576 ± 0.320

22.338 ± 1.786

28.106 ± 2.545

Neoline

MG

3.245 ± 0.999

0.333 ± 0.118

3.221 ± 1.040

7.417 ± 0.718

8.058 ± 0.838

ZCW

MPS

2.486 ± 0.349

0.250 ± 0.001

3.695 ± 1.005

7.559 ± 0.880

7.980 ± 0.757

Songorine

MG

2.638 ± 0.461

0.667 ± 0.236

13.961 ± 2.318

60.186 ± 6.505

64.576 ± 6.039

ZCW

MPS

2.522 ± 0.269

0.917 ± 0.773

17.665 ± 1.910

80.730 ± 5.544*

84.255 ± 5.364*

Fuziline

MG

3.235 ± 0.929

0.250 ± 0.001

1.396 ± 0.100

3.636 ± 0.369

3.938 ± 0.411

ZCW

MPS

3.196 ± 0.607

0.375 ± 0.125

1.032 ± 0.122*

3.590 ± 0.513

3.917 ± 0.539

Ephedrine

MG

1.852 ± 0.273

0.250 ± 0.001

673.726 ± 137.169

1721.094 ± 96.813

1746.650 ± 93.580

MH

MPS

1.736 ± 0.108

0.333 ± 0.118

661.523 ± 149.062

1559.029 ± 227.025

1575.759 ± 228.293

Methylephedrine

MG

4.131 ± 1.363

0.083 ± 0.001

14.012 ± 2.615

27.900 ± 4.829

30.265 ± 3.815

MH

MPS

4.331 ± 0.765

0.083 ± 0.001

12.523 ± 3.287

16.109 ± 2.770*

18.607 ± 4.409*

Albiflorin

MG

2.488 ± 0.458

0.250 ± 0.001

287.831 ± 42.177

424.990 ± 55.691

458.506 ± 69.994

BS

MPS

1.669 ± 0.080

0.139 ± 0.072

306.851 ± 57.880

644.268 ± 174.084*

698.946 ± 175.788*

Paeoniflorin

MG

2.132 ± 0.102

0.438 ± 0.108

1924.153 ± 225.157

2541.326 ± 95.887

2455.492 ± 223.257

BS

MPS

1.992 ± 0.126

0.396 ± 0.180

2063.985 ± 352.472

2870.390 ± 71.706**

2904.597 ± 68.691*

Oxypaeoniflorin

MG

3.408 ± 0.586

0.437 ± 0.110

28.569 ± 0.784

61.034 ± 2.601

67.007 ± 3.218

BS

MPS

3.399 ± 0.306

0.458 ± 0.093

31.514 ± 0.848*

70.355 ± 1.558*

75.327 ± 2.198*

Benzoylpaeoniflorin

MG

3.588 ± 0.489

0.139 ± 0.079

14.781 ± 2.659

27.904 ± 5.404

30.566 ± 6.082

BS

MPS

6.957 ± 2.271

0.083 ± 0.001

24.334 ± 3.995*

31.559 ± 6.741

37.891 ± 9.822

Formononetin

MG

4.271 ± 0.406

0.083 ± 0.001

7.387 ± 1.162

15.278 ± 1.823

17.533 ± 1.685

HQ

MPS

3.756 ± 0.557

0.250 ± 0.001

4.499 ± 0.902*

12.291 ± 1.983

13.592 ± 1.930

Calycosin

MG

4.942 ± 0.315

0.083 ± 0.001

8.479 ± 2.434

12.296 ± 1.063

14.276 ± 1.185

HQ

MPS

3.531 ± 0.666

0.083 ± 0.001

6.610 ± 1.443

12.353 ± 0.972

13.577 ± 0.642

Calycosin-7-glycoside

MG

2.342 ± 0.959

0.110 ± 0.062

17.607 ± 2.640

17.473 ± 2.858

18.097 ± 2.629

HQ

MPS

2.113 ± 0.779

0.083 ± 0.001

15.506 ± 2.308

15.987 ± 2.778

16.625 ± 2.476

Liquiritin

MG

2.089 ± 0.132

0.167 ± 0.083

125.917 ± 18.484

300.440 ± 52.811

306.988 ± 53.933

GC

MPS

3.301 ± 0.429

0.083 ± 0.001

190.023 ± 19.153*

321.663 ± 49.723

339.781 ± 52.584

Isoliquiritin

MG

5.850 ± 2.022

0.194 ± 0.079

13.586 ± 1.061

23.305 ± 0.956

30.845 ± 2.926

GC

MPS

7.608 ± 1.853

0.111 ± 0.062

14.210 ± 1.547

21.893 ± 1.756

33.055 ± 3.187

Liquiritigenin

MG

1.841 ± 0.242

0.139 ± 0.079

25.519 ± 7.560

48.549 ± 6.497

49.404 ± 6.315

GC

MPS

1.448 ± 0.025

0.083 ± 0.001

23.367 ± 4.695

47.195 ± 4.360

47.548 ± 4.374

Isoliquiritigenin

MG

3.117 ± 0.571

0.083 ± 0.001

4.003 ± 0.545

8.764 ± 1.421

9.614 ± 1.601

GC

MPS

3.871 ± 0.889

0.167 ± 0.083

5.421 ± 0.422*

9.467 ± 1.445

10.514 ± 1.272

Glycyrrhizic acid

MG

7.605 ± 1.142

0.500 ± 0.001

3796.250 ± 303.817

23,076.672 ± 1971.518

25,908.272 ± 2650.703

GC

MPS

7.254 ± 0.086

0.667 ± 0.236

5196.097 ± 705.783*

29,642.523 ± 2974.308

27,449.610 ± 2279.134

Glycyrrhetinic acid

MG

10.666 ± 3.723

2.000 ± 0.001

7828.313 ± 282.922

28,800.324 ± 986.106

32,851.097 ± 2465.278

GC

MPS

10.750 ± 1.956

2.000 ± 0.001

11,572.293 ± 3757.206

30,512.597 ± 6563.268

34,507.972 ± 6423.101

Liquiritin apioside

MG

4.060 ± 0.589

0.250 ± 0.001

571.677 ± 49.414

941.302 ± 42.085

1053.558 ± 63.193

GC

MPS

2.969 ± 0.328

0.083 ± 0.001

850.691 ± 179.709

1580.263 ± 242.037*

1669.308 ± 244.694*

  1. *p < 0.05, **p < 0.01, compared with the MG group
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Chinese Medicine

ISSN: 1749-8546

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