Fig. 2From: Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancerS.C triggers intrinsic apoptosis in prostate cancer cell. After the cells were treated with 1.0 μM S.C for 48 h, apoptosis rate of VCaP a, b, PC3 c, d and DU145 e, f cells was detected by flow cytometry. After the cells were treated with 0, 0.5,1.0 μM S.C for 24 h or 48 h, Hoechst 33,258 staining was used to observe the morphological changes of PC3 g and DU145 h cells. Intrinsic and extrinsic apoptosis related proteins level in PC3 i and DU145 j cells receiving 0, 0.5,1.0 μM S.C treatments for 48 hBack to article page