Fig. 2

Immunosuppressed rats exhibit depressive/anxiety-like behavior, which is attenuated after HPM binding inhibitor treatment. A, B Schematic representation of OFT (n = 8 per each group). C, D Schematic representation of EPM (n = 5 per each group). Data were analyzed using Kruskal–Wallis H-statistic test. ^*p < 0.05, ^**p < 0.01vs NG. NS: no significance; OFT: open-field test; EPM: elevated plus-maze; NG: normal group; CTX: cyclophosphamide; HPM: Herb-partitioned moxibustion; aCD28: anti-CD28; aCTLA-4: anti-CTLA-4; LEV: Levamisole