Fig. 1

SKP alleviates kidney injury in DKD mice. A After 1 week of adaptive feeding, the mice were fed with HFD for 4 weeks and then intraperitoneally injected with STZ 40 mg/kg/ day for 5 consecutive days. After the model was successfully established, the drug groups were given oral feeding, and the model group (n = 6) was given the same volume of normal saline. The treatment lasted for 7 weeks. B–G SKP and Val alleviated kidney damage and fasting blood glucose (FBG) in DKD mice. B Changes in body weight of mice in each group during drug administration. C FBG level. D 24-h urine protein. E BUN levels. F Serum creatinine level. G H&E staining and PAS staining of kidney tissues of mice (400 × magnification, bar = 100 µm). *P < 0.05, **P < 0.01, and ***P < 0.001vs. control group. ^#P < 0.05, ^##P < 0.01, and ^###P < 0.001 vs. DKD group, ns no significance