Fig. 6

Effect of ONSMP on cAMP/Rap1A signaling pathway and myocardial fibrosis effector proteins. A, B Representative Western blot strips of cAMP/Rap1A signaling pathway and myocardial fibrosis effector proteins in myocardium with GAPDH as an internal reference. C–L Statistical plots of β1-AR, AC6, Epac1, Rap1A-GTP, p-STAT3, CCND1, α-SMA, FSP-1, COL I, and COL III. Data are presented as mean ± SD, n = 3. ^##P < 0.01 vs the sham; ^*P < 0.05, ^**P < 0.01 vs the model; ^&&P < 0.01 vs the ONSMP-L; ^※P < 0.05, ^※※P < 0.01 vs the ONSMP-H