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Table 4 Affinity of ONSMP active ingredients to core targets

From: Optimized New Shengmai Powder modulation of cAMP/Rap1A signaling pathway attenuates myocardial fibrosis in heart failure

Core target

Active component

Affinity

β1-AR

Baicalin

− 9.5

AC6

Vitamin D

− 7.7

EPAC1

Resveratrol

− 7.3

RAP1A

Tanshinone IIA

− 7.3

STAT3

Apigenin

− 6.1

 

Calycosin

− 6.2

 

Capsaicin

– 5.6

 

Cryptotanshinone

− 6.1

 

Emodin

− 7

 

Resveratrol

− 5.8

 

Rhein

− 6.8

CCND1

15,16-dihydrotanshinone-i

− 8

 

Apigenin

− 7.2

 

Capsaicin

− 6.6

 

Cryptotanshinone

− 7.9

 

Ursolic-acid

− 6.7