Fig. 1

The combination of PTX and CK can significantly inhibit the viability of NSCLC cells. A The Lewis cells were treated with PTX for 48 h, the growth inhibition effect was assessed by MTT assay. B The Lewis cells were treated with CK or CK combined with 10 nM PTX for 48 h, the growth inhibition effect was assessed by MTT assay. C The A549 cells were treated with CK alone or CK combined with 10 nM PTX for 48 h, the growth inhibition effect was assessed by MTT assay. D–F The Lewis and A549 cells treated with PTX, CK or CK combined with 10 nM PTX for 48 h were incubated with EdU for the detection of cell viability by fluorescence microscope. G The Lewis and A549 cells treated with PTX, CK or CK combined with 10 nM PTX for 48 h were stained by crystal violet solution, the cell viability was represented by colony forming efficiency. H, I The Lewis cells were treated with CK combined with 10 nM PTX for 48 h, apoptotic cells (%) were detected by Flow Cytometry. J The PBMC and 293T cells were treated with CK combined with 10 nM PTX for 48 h, the cell viability was assessed by MTT assay. Data are mean ± SD for ≥ 3 independent experiments; ***P < 0.001, ****P < 0.0001, vs Ctrl or CK (0 μM)