Fig. 4

The Bufei Yishen formula enhances the integrity of tight junctions in COPD rats. BYF (11.6 g/kg) and doxophylline (Doxo: 36 mg/kg) were administered to COPD rats for 9 to 16 weeks. A, B The content of ZO-1 and OCLN in pulmonary tissues was determined using immunofluorescence. Fluorescence images (1 and OCLN in pulmonary tissue (C, D) Values are expressed as the mean ± SEM (n = 6), **P < 0.01, versus the control group; ^#P < 0.05, ^##P < 0.01, versus the model group