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Fig. 6 | Chinese Medicine

Fig. 6

From: Bufei Yishen formula protects the airway epithelial barrier and ameliorates COPD by enhancing autophagy through the Sirt1/AMPK/Foxo3 signaling pathway

Fig. 6

Comprehensive analysis of the targets of the Bufei Yishen formula and COPD genes. A UHPLC Q-Extractive Orbitrap-MS/MS was used to characterize the chemical constituents of the 95% fraction of BYF extract. B Compound and target network of the Bufei Yishen formula. C DEG volcano map of Model (BEAS-2B cell induced by CSE) vs. Control (BEAS-2B cell). D DEG cluster heatmap of Model (BEAS-2B cell induced by CSE) vs. Control (BEAS-2B cell). E The PPI network was constructed by combining Bufei Yishen formula targets and COPD genes. F The top 50 genes and targets were based on the degree ranking. G The top 50 targets and genes were analyzed using DAVID for KEGG pathway enrichment. H Sankey diagram of the components and targets associated with tight junctions, adherens junctions, autophagy, and the AMPK and FoxO signaling pathways

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Chinese Medicine

ISSN: 1749-8546

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