Fig. 7

The STING pathway is critical for Ta-IIA, As-IV, and Co effect on HR-induced HL1 cells. The effects of Ta-IIA, As-IV and Co on cell activity, apoptosis, oxidative stress and inflammation were detected in HL1 cells after STING siRNA and diabZI administration, respectively. A HL1 cells STING siRNA cell activity after Ta-IIA, As-IV and Co treatment. B Representative results of apoptosis rates measured in HL1 cells using flow cytometry. C. Representative western blots of Bax, Bcl2, Cleaved Caspase3. D The quantitative analysis of protein expression in (C). E Representative picture of the fluorescence curve of DCF in HL1 cells. F Cell activity of Ta-IIA, As-IV and Co treatment after diabZI administration. G Representative pictures of apoptosis rates of HL1 cells measured by flow cytometry. H Representative diagram of the DCF fluorescence curve in HL1 cells. I Representative western blotting of apoptosis-associated proteins. J Quantitative analysis of protein expression in (I). Data are presented as mean ± SEM. (n = 3 in each group). *p < 0.05, **p < 0.01, ***p < 0.001, ns = not statistically significant