Fig. 7From: Trachelogenin alleviates osteoarthritis by inhibiting osteoclastogenesis and enhancing chondrocyte survivalThe schematic diagram of the mechanisms of TCG in BMMs and PMCs. TCG inhibited osteoclastogenesis and function through binding to Rap1 and inhibiting Rap1/integrin αvβ3/c-Src/Pyk2 signaling cascade in BMMs. Besides, TCG promoted the proliferation of PMCs while suppressing apoptosis by upregulating HIF1α, and thereby promoting glycolysisBack to article page