Fig. 7

CPT inhibits the growth of melanoma in vivo. A Schematic diagram for the construction of subcutaneous transplantation tumor models with B16F10 cells. B The representive image of melanoma solid tumors dissected from the mice transplanted with B16F10. C Body weight changes in mice. D Measurement of tumor volume in mice using a vernier caliper. E Tumor weight and tumor growth inhibition rate. F Ki67 and TUNEL staining of B16F10 cell tumor tissues. G The key kinases activity of glycolysis was measured in melanoma tissue. H The glycolytic metabolites were detedted in melanoma tissue. Compared with the model group, * P < 0.05, ** P < 0.01, *** P < 0.001