Fig. 9

IGLR promotes diabetic wound closure through the COX2/PEG2 signaling pathway. A The Western blot assay showed COX2, NLRP3, NF-κB, IL-1β, and ASC levels in wound tissues of genetically modified mice after 14 days of IGLR treatment. B–F Quantification of western blots of (A) (n = 3). G Immunofluorescence analysis of IL-6 (red) and IL-1β (green) within wound tissues at 14 days postoperatively (scale bar, 50 μm). H, I Quantification of IL-6 and IL-1β in immunofluorescence staining (n = 3). ^###P < 0.005, ^####P < 0.001 versus positive control group, *P < 0.05, **P < 0.01, ***P < 0.005 versus vehicle group, one-way ANOVA and Tukey’s multiple comparison test. Results are shown to be means ± SEM