Fig. 6

Schematic illustration of the possible mechanisms that DSD-induced changes in gut microbiota ameliorate OIPN symptoms. DSD treatment beneficially regulated OXA-induced gut dysbiosis by enriching beneficial bacteria such as Faecalibaculum, Allobaculum, Dubosiella, and Rhodospirillales_unclassified. This lead to reduced intestinal permeability, decreased LPS leakage, increased SCFA levels, decreased neurotransmitters and neurotoxins, increased neuroprotective agents, alleviating DRG inflammation and hyperalgesia