Fig. 6

Integration analysis results. A Joint-Pathway analysis of Model-vs-Control and CH-vs-Model groups. B, C Correlation analysis between metabolic biomarkers and DEGs on the basis of spearman rank. D qRT-PCR validation of the 10 genes. Results are represented by mean ± SEM (n = 3). #P < 0.05, ##P < 0.01 versus Control group; *P < 0.05, **P < 0.01 versus Model group. E Changes in metabolites (blue squares) and differential genes (red circles) in the 4 metabolism on the basis of integrated analysis. The red arrow indicates the increase or decrease of Model group relative to Control group. The green arrow reveals the increase or decrease of CH  group relative to Model group