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Table 2 The information of 12 key targets between compounds and hypertension targets

From: A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model

Gene Compounds Gene Compounds
VEGFA Glucoside MAPK1 Cedar acid
NPY Ferulic Acid MAPK1 Ferulic Acid
EGF Salicylic acid NOS3 L-Bornyl acetate
EGF Nicotinic acid NOS3 p-Hydroxybenzoic acid
EGF p-Hydroxybenzoic acid NOS3 Salicylic acid
EGFR Naringenin NOS3 Pulegone
TH (1R,2R,5 S)-2,6,6-trimethylnorpinan-3-one NOS3 Cedar acid
TH Ferulic Acid NOS3 Nicotinic acid
TH Histidine NOS3 Histidine
NGF (-)-alpha-Pinene NOS3 (R)-linalool
NGF p-Hydroxybenzoic acid NOS3 5-Hydroxymethylfurfural
NGF (-)-nopinene ESR1 L-Bornyl acetate
SRC Shikimic Acid ESR1 (1R,2R,5 S)-2,6,6-trimethylnorpinan-
3-one
SRC Nicotinic acid ESR1 Pratensein
SRC Histidine ESR1 Alpha-Terthienyl methyl acetate
PTGS2 Naringenin ESR1 Diosgenin
PTGS2 Histidine ESR1 (+)-Isoborneol
PTGS2 Demethylwedelolactone ESR1 Sitosterol
PTGS2 Acacetin ESR1 Stigmasterol
PTGS2 Ferulic Acid ESR1 Butin
PTGS2 Xanthanoic acid ESR1 Baimuxinol
PTGS2 5-Hydroxymethylfurfural ESR1 (Z)-1-(2,4-dihydroxyphenyl)-3-
(3,4-dihydroxyphenyl)prop-2-en-1-one
PTGS2 (L)-alpha-Terpineol ESR1 (-)-nopinene
PTGS2 (1R,2R,5 S)-2,6,6-trimethylnorpinan-3-one ESR1 1,8-cineole
PTGS2 Pulegone ESR1 (-)-alpha-Pinene
PTGS2 MENTHOL ESR1 Demethylwedelolactone
PTGS2 L-Limonen ESR1 3’-O-Methylorobol
PTGS2 Salicylic acid ESR1 Wedelolactone
PTGS2 Nicotinic acid ESR1 Luteolin
PTGS2 p-Hydroxybenzoic acid ESR1 Acacetin
PTGS2 L-Bornyl acetate ESR1 Dihydroresveratrol
PTGS2 Cedar acid ESR1 Naringenin
CCL2 Ferulic Acid ESR1 Cis-resveratrol
MAPK1 p-Hydroxybenzoic acid