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Table 2 The information of 12 key targets between compounds and hypertension targets

From: A network pharmacology-based approach to explore the active ingredients and molecular mechanism of Lei-gong-gen formula granule on a spontaneously hypertensive rat model

Gene

Compounds

Gene

Compounds

VEGFA

Glucoside

MAPK1

Cedar acid

NPY

Ferulic Acid

MAPK1

Ferulic Acid

EGF

Salicylic acid

NOS3

L-Bornyl acetate

EGF

Nicotinic acid

NOS3

p-Hydroxybenzoic acid

EGF

p-Hydroxybenzoic acid

NOS3

Salicylic acid

EGFR

Naringenin

NOS3

Pulegone

TH

(1R,2R,5 S)-2,6,6-trimethylnorpinan-3-one

NOS3

Cedar acid

TH

Ferulic Acid

NOS3

Nicotinic acid

TH

Histidine

NOS3

Histidine

NGF

(-)-alpha-Pinene

NOS3

(R)-linalool

NGF

p-Hydroxybenzoic acid

NOS3

5-Hydroxymethylfurfural

NGF

(-)-nopinene

ESR1

L-Bornyl acetate

SRC

Shikimic Acid

ESR1

(1R,2R,5 S)-2,6,6-trimethylnorpinan-

3-one

SRC

Nicotinic acid

ESR1

Pratensein

SRC

Histidine

ESR1

Alpha-Terthienyl methyl acetate

PTGS2

Naringenin

ESR1

Diosgenin

PTGS2

Histidine

ESR1

(+)-Isoborneol

PTGS2

Demethylwedelolactone

ESR1

Sitosterol

PTGS2

Acacetin

ESR1

Stigmasterol

PTGS2

Ferulic Acid

ESR1

Butin

PTGS2

Xanthanoic acid

ESR1

Baimuxinol

PTGS2

5-Hydroxymethylfurfural

ESR1

(Z)-1-(2,4-dihydroxyphenyl)-3-

(3,4-dihydroxyphenyl)prop-2-en-1-one

PTGS2

(L)-alpha-Terpineol

ESR1

(-)-nopinene

PTGS2

(1R,2R,5 S)-2,6,6-trimethylnorpinan-3-one

ESR1

1,8-cineole

PTGS2

Pulegone

ESR1

(-)-alpha-Pinene

PTGS2

MENTHOL

ESR1

Demethylwedelolactone

PTGS2

L-Limonen

ESR1

3’-O-Methylorobol

PTGS2

Salicylic acid

ESR1

Wedelolactone

PTGS2

Nicotinic acid

ESR1

Luteolin

PTGS2

p-Hydroxybenzoic acid

ESR1

Acacetin

PTGS2

L-Bornyl acetate

ESR1

Dihydroresveratrol

PTGS2

Cedar acid

ESR1

Naringenin

CCL2

Ferulic Acid

ESR1

Cis-resveratrol

MAPK1

p-Hydroxybenzoic acid

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