Fig. 9
From: Therapeutic potential of triptolide in autoimmune diseases and strategies to reduce its toxicity
The inflammation-targeted pH-sensitive GDR-TPT not only itself has anti-inflammatory property, but also promotes drug releasing at the intracellular regions of inflamed site, thereby enhancing anti-arthritic effect and improving drug safety. A Scheme of GDR-TPT nanoparticle. B The distribution of DR and GDR from 4 to 72 h after i.v. injection. C Histologic results of representative liver and kidney tissues from mice with different treatment. (Reprinted with permission from [150], Copyright 2019 Elsevier B.V.)