Fig. 5

NXT restored cardiovascular malformation in heg1^△25 mutant. A Lateral views of zebrafish embryos at 96 hpf. heg1^△25 mutant embryos showing pericardial edema (red dashed line) and venous congestion (red arrows). B Blood flow motion ratios of three groups of zebrafish embryos based on RBCs pixel density changes. C Optimal recovery concentration of NXT. D Pericardial area of the three groups of zebrafish larvae (n  =  15 embryos/group). E Heart rates of three groups of zebrafish larvae (n  =  15 embryos/group). F SV-BA distance of three groups of zebrafish larvae (n  =  15 embryos/group). ^#p  <  0.05, ^##p  <  0.01, ^###p  <  0.001 vs control group; *p  <  0.05, ***p  <  0.001 vs heg1^△25 mutant group