Table 1 Zebrafish Homologues associated with human DCM genes based on RNA-seq data
Human DCM-associated gene | Zebrafish orthologue | Gene ID | Cardiomyopathy subtype(s) | log2(FoldChange) | padj |
|---|---|---|---|---|---|
ACTC1 (cardiac actin) | actc1a | ENSDARG00000042535 | DCM, HCM, LVNC | 2.605409266 | 2.23E-07 |
actc1b | ENSDARG00000076126 | DCM, HCM, LVNC | 3.204639486 | 7.79E-10 | |
MYH6 (myosin heavy chain 6) | myh6 | ENSDARG00000090637 | DCM, HCM, CHD | 2.966691137 | 4.27E-09 |
MYH7 (myosin heavy chain 7) | myh7 | ENSDARG00000079564 | DCM, HCM, LVNC | 2.62564815 | 1.82E-07 |
myh7ba | ENSDARG00000076075 | DCM, HCM, LVNC | 3.181888154 | 5.38E-10 | |
myh7bb | ENSDARG00000035322 | DCM, HCM, LVNC | 2.377845495 | 3.79E-06 | |
myh7l | ENSDARG00000079782 | DCM, HCM | 2.9740424 | 3.10E-09 | |
myhz1.1 | ENSDARG00000067990 | DCM, HCM | 2.59151567 | 8.45E-05 | |
TNNC (cardiac troponin C) | tnnc1a | ENSDARG00000011400 | HCM, LVNC | 2.529089309 | 6.54E-07 |
tnnc1b | ENSDARG00000037539 | HCM, LVNC | 2.626641531 | 3.45E-07 | |
TNNT (cardiac troponin T) | tnnt1 | ENSDARG00000037954 | DCM, HCM, LVNC | 3.661572878 | 1.30E-05 |
tnnt2a | ENSDARG00000020610 | DCM, HCM, LVNC | 2.345399238 | 3.72E-06 | |
tnnt2b | ENSDARG00000100694 | DCM, HCM, LVNC | 3.182087004 | 4.43E-04 | |
TNNI (cardiac troponin I) | tnni4a | ENSDARG00000099870 | DCM | 4.604088258 | 7.20E-16 |
tnni1b | ENSDARG00000052708 | DCM, HCM | 2.918318845 | 7.07E-09 | |
tnni3k | ENSDARG00000086933 | DCM, HCM | 2.40317011 | 5.28E-04 | |
TTN (titin) | ttn.1 | ENSDARG00000000563 | DCM, HCM, ARVC | 2.614507859 | 2.41E-07 |
ttn.2 | ENSDARG00000028213 | DCM, HCM, ARVC | 3.388962093 | 2.25E-11 | |
MYBPC3 (myosin-binding protein C) | mybpc3 | ENSDARG00000011615 | DCM, HCM | 3.171024301 | 3.74E-10 |
NEXN (nexilin) | nexn | ENSDARG00000057317 | DCM, HCM | 2.13189099 | 2.36E-04 |
NKX (NK2 homeobox) | nkx2.5 | ENSDARG00000018004 | DCM, HCM | 2.318274388 | 4.34E-05 |
nkx2.7 | ENSDARG00000021232 | DCM | 2.074287056 | 4.63E-04 | |
HEG1 (heart development protein with EGF like domains 1) | heg1 | ENSDARG00000018441 | DCM | 3.092539 | 4.49E-09 |
TBX20 (T-box 20) | tbx20 | ENSDARG00000005150 | DCM | 1.87288 | 4.85E-04 |
CCM2L (CCM2 like scaffold protein) | ccm2l | ENSDARG00000063089 | DCM | 2.074250424 | 2.49E-04 |
SLC8A1 (solute carrier family 8 member A1) | slc8a1a | ENSDARG00000013422 | DCM, HCM | 3.344777218 | 7.19E-11 |
LAMA2 (laminin, α2) | lama2 | ENSDARG00000099390 | DCM | 1.937049252 | 3.66E-03 |
TPM4 (tropomyosin 4) | tpm4a | ENSDARG00000023963 | DCM, HCM | 2.275421133 | 7.24E-06 |
tpm4b | ENSDARG00000019128 | DCM, HCM | 1.94540804 | 2.02E-04 | |
ACTN2 (actinin, α2) | actn2b | ENSDARG00000071090 | DCM, HCM | 2.537681759 | 8.35E-07 |
CSRP3 (cysteine and glycine-rich protein 3) | csrp3 | ENSDARG00000101706 | DCM, HCM | 5.082307638 | 5.42E-19 |
EYA4 (eyes absent homolog 4) | eya4 | ENSDARG00000012397 | DCM | 1.763847085 | 2.92E-03 |