Li SY, Li JC, Ma EX, Gu J, Shi ZL. Analysis of potential drug effective substance and mechanism of Ma-Xing-Shi-Gan decoction in treating COVID-19. J Southwest Minzu Univ (Nat Sci Ed). 2020;46:354–69.
Google Scholar
Luo H, et al. Reflections on treatment of COVID-19 with traditional Chinese medicine. Chin Med. 2020;15:94.
Article
PubMed
PubMed Central
CAS
Google Scholar
Li LC, Han YY, Zhang ZH, Zhou WC, Fang HM, Qu J, Kan LD. Chronic obstructive pulmonary disease treatment and pharmacist-led medication management. Drug Des Dev Ther. 2021;15:111–24.
Article
Google Scholar
World Health Organization. Coronavirus disease (COVID-19) pandemic. Geneva: WHO. 2021. https://www.who.int/emergencies/diseases/novel-coronavirus-2019. Accessed 12 Nov 2021.
Li LC, et al. Lianhua Qingwen prescription for coronavirus disease 2019 (COVID-19) treatment: advances and prospects. Biomed Pharmacother. 2020;130: 110641.
Article
PubMed
PubMed Central
CAS
Google Scholar
Soy M, Keser G, Atagündüz P, Tabak F, Atagündüz I, Kayhan S. Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment. Clin Rheumatol. 2020;39:2085–94.
Article
PubMed
PubMed Central
Google Scholar
Yang CX, Qu J, Liu YT, Meng SW, Wang BL, Feng MQ, Sun Y. Immune imbalance mechanism and intervention strategy in patients with coronavirus disease 2019 (COVID-19). Chin Pharmacol Bull. 2020;36:445–53.
Google Scholar
Liang Z, Chen X, Shi J, Hu H, Xue Y, Ung COL. Efficacy and safety of traditional Chinese medicines for non-alcoholic fatty liver disease: a systematic literature review of randomized controlled trials. Chin Med. 2021;16(1):9.
Article
PubMed
PubMed Central
Google Scholar
Ng JY. The regulation of complementary and alternative medicine professions in Ontario, Canada. Integr Med Res. 2020;9:12–6.
Article
PubMed
PubMed Central
Google Scholar
Han L, et al. Potential mechanism prediction of Cold-Damp Plague Formula against COVID-19 via network pharmacology analysis and molecular docking. Chin Med. 2020;15:78.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhuang J, Dai X, Wu Q, Cai H, Fu X, Zhang W, Chen B. A meta-analysis for Lianhua Qingwen on the treatment of coronavirus disease 2019 (COVID-19). Complement Ther Med. 2021;60: 102754.
Article
PubMed
PubMed Central
Google Scholar
Wang FC, Shen BX, He CY, Zhao WC, Nie SL. Clinical efficacy and mechanism of Lianhua Qingwen granule on COVID-19 based on network pharmacology research. Pharmacol Clin Chin Mater Med. 2020;36:93–101.
Google Scholar
Ling XY, Tao JL, Sun X, Yuan B. Exploring material basis and mechanism of Lianhua Qingwen prescription against coronavirus based on network pharmacology. Chin Trad Herb Drug. 2020;51:1723–30.
Google Scholar
Wang L, Yang ZH, Zhang HR, Yu HX, Yang K, Fu BH, Yang HT. Study on the network pharmacology and evidences of Lianhua Qingwen in the treatment of novel coronavirus (2019 nCoV) Pneumonia. J Chin Med Mater. 2020;43:772–8.
Google Scholar
Runfeng L, et al. Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2). Pharmacol Res. 2020;156: 104761.
Article
PubMed
PubMed Central
CAS
Google Scholar
Xia QD, et al. Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19. Cell Prolif. 2020;53: e12949.
Article
PubMed
PubMed Central
CAS
Google Scholar
Hu C, Liang M, Gong F, He B, Zhao D, Zhang G. Efficacy of Lianhua Qingwen compared with conventional drugs in the treatment of common pneumonia and COVID-19 pneumonia: a meta-analysis. Evid Based Complement Alternat Med. 2020;2020: 5157089.
Article
PubMed
PubMed Central
Google Scholar
Wang SH, Liu JF, Zhang YL, Dong Z. Systematic review of efficacy and safety of Lianhua Qingwen capsules in treatment of viral influenza. Zhongguo Zhong Yao Za Zhi. 2019;44:1503–8.
PubMed
Google Scholar
Song JX, Zhang ZH, Zhao SM, Li H, Guo J. Patent information analysis on traditional Chinese medicine for prevention and treatment of COVID-19. Drug Eva Res. 2020;43:565–90.
Google Scholar
Bao Y, Gao Y, Cui X. Effect of Shufeng Jiedu capsules as a broad-spectrum antibacterial. Biosci Trends. 2016;10:74–8.
Article
PubMed
CAS
Google Scholar
Bao YY, Gao YJ, Shi YJ, Bao L, Yao RM, Mao X, Cui XL. Study on broad-spectrum antiviral effect of Shufeng Jiedu capsules. J New Chin Med. 2019;51:5–8.
Google Scholar
Ji S, Bai Q, Wu X, Zhang DW, Wang S, Shen JL, Fei GH. Unique synergistic antiviral effects of Shufeng Jiedu capsule and oseltamivir in influenza A viral-induced acute exacerbation of chronic obstructive pulmonary disease. Biomed Pharmacother. 2020;121:109652.
Article
PubMed
CAS
Google Scholar
Ma L, Huang Y, Hou YB, Bi HY, Pan J, Ge DZ, Liu J, Zhang TJ. Compatibility rationality and mechanism of Shufeng Jiedu capsule in treatment of pneumonia. Drug Eva Res. 2019;42:1769–73.
Google Scholar
Xia L, et al. Shufeng Jiedu, a promising herbal therapy for moderate COVID-19: antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a clinical real-world pragmatic study. Phytomedicine. 2021;85: 153390.
Article
PubMed
CAS
Google Scholar
Xiong H, Dong Z, Lou G, Gan Q, Wang J, Huang Q. Analysis of the mechanism of Shufeng Jiedu capsule prevention and treatment for COVID-19 by network pharmacology tools. Eur J Integr Med. 2020;40: 101241.
Article
PubMed
PubMed Central
Google Scholar
Chen X, Yin YH, Zhang MY, Liu JY, Li R, Qu YQ. Investigating the mechanism of ShuFeng JieDu capsule for the treatment of novel coronavirus pneumonia (COVID-19) based on network pharmacology. Int J Med Sci. 2020;17:2511–30.
Article
PubMed
PubMed Central
CAS
Google Scholar
Tao Z, Zhang L, Friedemann T, Yang G, Li J, Wen Y, Wang J, Shen A. Systematic analyses on the potential immune and anti-inflammatory mechanisms of Shufeng Jiedu capsule against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused pneumonia. J Funct Foods. 2020;75: 104243.
Article
PubMed
PubMed Central
CAS
Google Scholar
Qu XK, et al. A retrospective study on the treatment of COVID-19 by Shufeng Jiedu capsule combined with abidor. Chin Trad Herb Drug. 2020;51:1167–70.
Google Scholar
Wang Z, Chen X, Lu Y, Chen F, Zhang W. Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and western medicine treatment. Biosci Trends. 2020;14:64–8.
Article
PubMed
CAS
Google Scholar
Chen J, Lin S, Niu C, Xiao Q. Clinical evaluation of Shufeng Jiedu capsules combined with umifenovir (Arbidol) in the treatment of common-type COVID-19: a retrospective study. Expert Rev Respir Med. 2021;15:257–65.
Article
PubMed
CAS
Google Scholar
Huo ZP, Liu YX, Hao L, Wang Y, He Y, Zhou SP, Yan KJ. Research progress on potential application of Huoxiang Zhengqi in prevention and treatment of coronavirus disease 2019. Drug Clin. 2020;35:1–6.
Google Scholar
Yu DD, Liao X, Xie YM, Li HM, Zhang YL, Wang GQ, Zhao J. Systematic review and meta-analysis of Huoxiang Zhengqi pills combined with western medicine for acute gastroenteritis. Zhongguo Zhong Yao Za Zhi. 2019;44:2914–25.
PubMed
Google Scholar
Zhao HJ, et al. Huoxiang Zhengqi formulas for treatment of gastrointestinal type cold: a systematic review and meta-analysis. Zhongguo Zhong Yao Za Zhi. 2017;42:1495–9.
PubMed
Google Scholar
Li H, Lu CZ, Tang KC. Clinical observation on treatment of SARS with combination of chaihu droplet pill and huoxiang zhengqi droplet pill. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004;24:321–4.
PubMed
CAS
Google Scholar
Yan BH, et al. Large- scale prospective clinical study on prophylactic intervention of COVID-19 in community population using Huoxiang Zhengqi oral liquid and Jinhao Jiere granules. Zhongguo Zhong Yao Za Zhi. 2020;45:2993–3000.
PubMed
Google Scholar
Xiao M, et al. Efficacy of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules in treatment of COVID-19: a randomized controlled trial. Pharmacol Res. 2020;161: 105126.
Article
PubMed
PubMed Central
CAS
Google Scholar
Liu Y, et al. Literature analysis of Chinese patent medicine treatment in the observation period of clinical management of corona virus disease 2019 (trial 6th edition). Clin Med J. 2020;18:62–6.
Google Scholar
Fan YP, Wang YP, Ma Y, Zhao C, Zhang HM. Analysis on composition mechanism of Qingfei Paidu Tang from pathogenesis of cold pestilence of COVID-19. Chin J Exp Trad Med Form. 2020;26:1–5.
Google Scholar
Wang RQ, Yang SJ, Xie CG, Shen QL, Li MQ, Lei X, Li JK, Huang M. Clinical observation of Qingfeipaidu decoction in the treatment of COVID-19. Pharm Clin Chin Mater Med. 2020;36:13–8.
CAS
Google Scholar
Xu DY, Xu YL, Wang ZW, Lü YL, Zhu HL, Song T. Mechanism of Qingfeipaidu decoction on COVID-19 based on network pharmacology. Pharm Clin Chin Mater Med. 2020;36:26–32.
Google Scholar
Zhang L, et al. Association between use of Qingfei Paidu Tang and mortality in hospitalized patients with COVID-19: a national retrospective registry study. Phytomedicine. 2021;85: 153531.
Article
PubMed
PubMed Central
CAS
Google Scholar
Xin S, et al. Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment. Biomed Pharmacother. 2020;129: 110500.
Article
PubMed
PubMed Central
CAS
Google Scholar
Sun YN, et al. A multi-center clinical study of Qingfei Paidu Tang on 295 cases of mild/common type COVID-19. J Trad Chin Med. 2021;62:599–603.
Google Scholar
Shi N, et al. Association between early treatment with Qingfei Paidu decoction and favorable clinical outcomes in patients with COVID-19: a retrospective multicenter cohort study. Pharmacol Res. 2020;161: 105290.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zheng ZW, Ye WQ, Liu CF. Study on mechanism of Shuanghuanglian oral liquid in treating novel coronavirus pneumonia based on network pharmacology. J Chin Med Mater. 2020;43:1519–26.
Google Scholar
Gao YL, Wang LL. Effect of children Shuanghuanglian mixture combined with oseltamivir phosphate in the treatment of influenza. J Clin Pathol Res. 2020;40:332–6.
Google Scholar
Su HX, et al. Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. Acta Pharmacol Sin. 2020;41:1167–77.
Article
PubMed
PubMed Central
CAS
Google Scholar
Xie LH, Lin XY, He P, Liu Y, Hu GH. Research on Shuanghuanglian oral liquid for treatment of COVID-19 based on network pharmacology and molecular docking technology. J Hunan Univ Chin Med. 2020;40:1123–31.
Google Scholar
Yang ZH, Yan HF, Yan YF, Wang L, Ji YS, Wang SP. Study on the molecular mechanism of Shuanghuanglian oral liquid inhibiting novel coronavirus (2019-nCoV) based on network pharmacology. J Chin Med Mater. 2020;43:2333–40.
Google Scholar
Ni L, Zhou L, Zhou M, Zhao J, Wang DW. Combination of western medicine and Chinese traditional patent medicine in treating a family case of COVID-19 in Wuhan. Front Med. 2020;14:210–4.
Article
PubMed
Google Scholar
Ni L, et al. Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial. Front Med. 2021;15:1–14.
Article
Google Scholar
Li GQ, et al. Treating influenza patients of wind-heat affecting Fei syndrome by Jinhua Qinggan granule: a double-blinded randomized control trial. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013;33:1631–5.
PubMed
Google Scholar
Gong PY, Guo YJ, Li XP, Wang N, Gu J. Exploring active compounds of Jinhua Qinggan granules for prevention of COVID-19 based on network pharmacology and molecular docking. Chin Trad Herb Drug. 2020;51:1685–93.
Google Scholar
Lin JR, Zheng WW, Zeng GX, Lin QZ. Study on the network pharmacology of Jinhua Qinggan granules in the treatment of COVID-19. J Chin Med Mater. 2020;43:2074–80.
Google Scholar
Liu Z, et al. Effect of Jinhua Qinggan granules on novel coronavirus pneumonia in patients. J Tradit Chin Med. 2020;40:467–72.
PubMed
Google Scholar
Duan C, et al. Clinical observation on Jinhua Qinggan granule combined with conventional western medicine therapy in treating mild cases of coronavirus disease 2019. J Trad Chin Med. 2020;61:1473–7.
Google Scholar
Yang MB, Dang SS, Huang S, Li YJ, Guo YL. Multi-center clinical observation of Reyanning mixture in treatment of novel coronavirus pneumonia. Chin J Exp Trad Med Form. 2020;26:7–12.
Google Scholar
Bao L, Shi YJ, Geng ZH, Sun J, Zhao RH, Du CQ, Chu YJ, Cui XL. Application of Reyanning mixture in evaluating combining disease with syndrome of human coronavirus pneumonia with pestilence attacking lung syndrome. Zhongguo Zhong Yao Za Zhi. 2020;45:1465–72.
PubMed
Google Scholar
Wang M, et al. Mechanism prediction and anti-virus compounds selection of Reyanning mixture in the treatment of COVID-19 based on network pharmacology and molecular docking technology. Mod Chin Med. 2020;22:484–91.
Google Scholar
Yang AP, Liu H, Liu F, Fan LX, Liao WQ, Guo JL, He K. Study of the mechanism of the Reyanning mixture involved in treating novel coronavirus pneumonia based on network pharmacology. Nat Prod Commun. 2020;15:1–12.
Google Scholar
Xie YZ, Ji SL, Zhong CT, Zhan SF, Huang HT, Liu XH. Study on the molecular mechanism of Huopuxialing decoction in treating corona virus disease base on network pharmacology. J Chin Med Mater. 2020;43:1284–94.
Google Scholar
Zhuo DT, Lu JY, Huang LP. Effect of modified huopo xialing decoction in treating pi-wei dampness-heat syndrome and its impact on the tongue epithelial cell apoptosis. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011;31:168–71.
PubMed
Google Scholar
Zhao HH, et al. Study on the potential mechanism of Huopu Xialing decoction in the treatment of COVID-19 based on network pharmacology. Pharmacol Clin Chin Mater Med. 2020;36:79–85.
Google Scholar
Fan MY, Liu J, Sun R. Analysis on material basis and efficacy network of Huopo Xialing decoction in treating damp pathogen stagnation of lung syndrome of early COVID-19. Chin Trad Herb Drug. 2020;51:2297–306.
Google Scholar
Fu C, Zhao Y, Xie M, Xiao HH, Li HM, Yang ZJ, Zuo XH. Study on the mechanism of Huopu Xialing decoction based on network pharmacology to explore the treatment of COVID-19. J Basic Chin Med. 2020;26:640–4.
Google Scholar
Yang PY, Yang MB, Qin LZ, Fu QQ. Experience of Huopu Xialing decoction in the treatment of antiviral drug induced liver injury in COVID-19 patients. J Shaanxi Univ Chin Med. 2021;44:9–17.
Google Scholar
Sun KB, Zhang XY, Liu J, Sun R. Network pharmacological analysis and mechanism prediction of Xiaochaihu decoction in treatment of COVID-19 with syndrome of pathogenic heat lingering in lung and obstructive cardinalate. Chin Trad Herb Drug. 2020;51:1750–60.
Google Scholar
Chen C, Liu YH, Cheng SB, Wu SL, Zhai XJ. The hepatoprotective effects of XCHD and MgIG against methotrexate-induced liver injury and inflammation in rats through suppressing the activation of AIM2 inflammasomes. Pathol Res Pract. 2020;216: 152875.
Article
PubMed
CAS
Google Scholar
Zheng JL, Lu BJ. Clinical observation of Xiaochaihu decoction combined with Yupingfeng powder in the treatment of suspected cases of COVID-19. J Liaoning Univ Trad Chin Med. 2020;23:134–7.
Google Scholar
He ZY, Wu KY, Liang GY, Jin FY, Li X, Feng H. Effect of different composition in Maxingshigan decoction on contents of glycyrrhizic acid. Chin Pharm J. 2008;43:264–7.
CAS
Google Scholar
Hsieh CF, Lo CW, Liu CH, Lin S, Yen HR, Lin TY, Horng JT. Mechanism by which ma-xing-shi-gan-tang inhibits the entry of influenza virus. J Ethnopharmacol. 2012;143:57–67.
Article
PubMed
Google Scholar
Zhong Y, et al. Effect of Maxing Shigan Tang on H1N1 influenza A virus-associated acute lung injury in mice. Intervirology. 2016;59:267–74.
Article
PubMed
CAS
Google Scholar
Yang R, et al. Chemical composition and pharmacological mechanism of Qingfei Paidu decoction and Ma Xing Shi Gan decoction against coronavirus disease 2019 (COVID-19): in silico and experimental study. Pharmacol Res. 2020;157: 104820.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhang HL, Huang ZG, Jiang X, Qiu Y, Huang TM, Lin ZQ, Liu TT. Study on the mechanism of Maxing Shigan decoction in the treatment of the severe novel coronavirus pneumonia based on network pharmacology. J Chin Med Mater. 2020;43:1777–83.
Google Scholar
Zhang SY, Li L, Zhang N, Xia HT, Lu FG, Li WQ. Systematic pharmacological strategies to explore the regulatory mechanism of Ma Xing Shi Gan decoction on COVID-19. Dig Chin Med. 2020;3:96–115.
Article
Google Scholar
Na B. Study on the effect of Maxingshigan decoction combined with western medicine in the treatment of infantile pneumonia. Guid Chin Med. 2020;18:242.
Google Scholar
Mou FZ, et al. Observation on curative effect of Maxing Shigan Sanren decoction in the treatment of new coronavirus pneumonia. J Pract Trad Chin Med. 2020;10:1259–60.
Google Scholar
Cui W, et al. Total glycosides of Yupingfeng protects against bleomycin-induced pulmonary fibrosis in rats associated with reduced high mobility group box 1 activation and epithelial-mesenchymal transition. Inflamm Res. 2015;64:953–61.
Article
PubMed
CAS
Google Scholar
Li L, et al. Total extract of Yupingfeng attenuates bleomycin-induced pulmonary fibrosis in rats. Phytomedicine. 2015;22:111–9.
Article
PubMed
Google Scholar
Xu L, Li LC, Zhao P, Qi LW, Li P, Gao J, Fei GH. Total polysaccharide of Yupingfeng protects against bleomycin-induced pulmonary fibrosis via inhibiting transforming growth factor-β1-mediated type I collagen abnormal deposition in rats. J Pharm Pharmacol. 2014;66:1786–95.
Article
PubMed
CAS
Google Scholar
Ma J, et al. Effects of YuPingFeng granules on acute exacerbations of COPD: a randomized, placebo-controlled study. Int J Chron Obstruct Pulm Dis. 2018;13:3107–14.
Article
Google Scholar
Wang R, Wang J, Shu J, Gu X, Li H, Zi Y, Liu S, Lin J. Efficacy and safety of Yu-Ping-Feng powder for asthma in children: a protocol of systematic review and meta-analysis of randomized controlled trials. Medicine. 2020;99: e18551.
Article
PubMed
PubMed Central
Google Scholar
Zhang LD, Lyu J, Xie YM, Sun MH. Systematic evaluation and meta-analysis on effectiveness and safety of Yupingfeng granules on recurrent respiratory tract infection. Zhongguo Zhong Yao Za Zhi. 2019;44:4379–86.
PubMed
Google Scholar
Huang LL, Xu R, Liu YW, Liu ZY. Study on active compounds of Yupingfeng San in preventing and treating COVID-19 based on network pharmacology and molecular docking. Pharmacol Clin Chin Mater Med. 2020;36:116–21.
Google Scholar
Zhang D, Zhang B, Lv JT, Sa RN, Zhang XM, Lin ZJ. The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence. Pharmacol Res. 2020;157: 104882.
Article
PubMed
PubMed Central
CAS
Google Scholar
National Health Commission of the People’s Republic of China. Diagnosis and treatment plan for COVID-19 (trial version 8 revision). Chin J Clin Infect Dis. 2021;14:81–8.
Google Scholar
Agrahari R, Mohanty S, Vishwakarma K, Nayak SK, Samantaray D, Mohapatra S. Update vision on COVID-19: structure, immune pathogenesis, treatment and safety assessment. Sens Int. 2021;2: 100073.
Article
PubMed
Google Scholar
Polidoro RB, Hagan RS, de Santis SR, Schmidt NW. Overview: systemic inflammatory response derived from lung injury caused by SARS-CoV-2 infection explains severe outcomes in COVID-19. Front Immunol. 2020;11:1626.
Article
PubMed
PubMed Central
CAS
Google Scholar