Zhao Z, Li Y, Zhou L, et al. Prevention and treatment of COVID-19 using traditional Chinese medicine: a review. Phytomedicine. 2021;85:153308.
CAS
PubMed
Google Scholar
An X, Zhang Y, Duan L, et al. The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19. Biomed Pharmacother. 2021;137:111267.
CAS
PubMed
PubMed Central
Google Scholar
An X, Duan L, Zhang YH, et al. The three syndromes and six Chinese patent medicine study during the recovery phase of COVID-19. Chin Med. 2021;16:44.
CAS
PubMed
PubMed Central
Google Scholar
Liu M, Gao Y, Yuan Y, et al. Efficacy and safety of integrated traditional Chinese and western medicine for Corona Virus Disease 2019 (COVID-19): a systematic review and meta-analysis. Pharmacol Res. 2020;158:104896.
CAS
PubMed
PubMed Central
Google Scholar
Xiong X, Wang P, Su K, et al. Chinese herbal medicine for coronavirus disease 2019: a systematic review and meta-analysis. Pharmacol Res. 2020;160:105056.
CAS
PubMed
PubMed Central
Google Scholar
Jiang F, Xu N, Zhou Y, et al. Contribution of traditional Chinese medicine combined with conventional western medicine treatment for the novel coronavirus disease (COVID-19), current evidence with systematic review and meta-analysis. Phytother Res. 2021;35(11):5992–6009.
CAS
PubMed
Google Scholar
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:71.
Google Scholar
National Health Commission of the People's Republic of China. Diagnosis and Treatment Protocol for COVID-19 Patients (Tentative 8th Edition). http://en.nhc.gov.cn/2020-09/07/c_81565.htm Accessed 20 July 2021.
Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.
PubMed
PubMed Central
Google Scholar
Liu SD, Chen WT, Chi CC. Association between medication use and bullous pemphigoid: a systematic review and meta-analysis. JAMA Dermato. 2020;156:891–900.
Google Scholar
Xiao M, Tian J, Zhou Y, Xu X, Min X, Lv Y, et al. Efficacy of Huoxiang Zhengqi dropping pills and Lianhua Qingwen granules in treatment of COVID-19: a randomized controlled trial. Pharmacol Res. 2020;161:105126.
CAS
PubMed
PubMed Central
Google Scholar
Zhang XY, Lv L, Zhou YL, Xie LD, Xu Q, Zou XF, et al. Efficacy and safety of Xiyanping injection in the treatment of COVID-19: a multicenter, prospective, open-label and randomized controlled trial. Phytother Res. 2021;35:4401–10.
CAS
PubMed
Google Scholar
Shi N, Guo L, Liu B, Bian Y, Chen R, Chen S, et al. Efficacy and safety of Chinese herbal medicine versus Lopinavir-Ritonavir in adult patients with coronavirus disease 2019: a non-randomized controlled trial. Phytomedicine. 2021;81:153367.
CAS
PubMed
Google Scholar
Duan C, Xia WG, Zheng CJ, Sun GB, Li ZL, Li QL, et al. Clinical observation on Jinhua Qinggan granule combined with conventional western medicine therapy in treating mild cases of coronavirus disease 2019. J Tradit Chin Med. 2020;61:1473–7.
Google Scholar
He Q, Zhang QJ, Gan XW, Li XG. Clinical analysis of Buzhong Yiqi decoction in treating mild cases of coronavirus disease 2019. J Emerg Tradit Chin Med. 2021;30:385–7.
Google Scholar
Fu XX, Lin LP, Tan XH. Clinical study on 37 cases of COVID-19 treated with integrated traditional Chinese and western medicine. Tradit Chin Drug Res Clin Pharmacol. 2020;31:600–4.
Google Scholar
Liu W, Su XY, Liao XL. Effect of antiviral drugs combined with traditional Chinese medicine on mild cases of coronavirus disease 2019. Contemp Med Symp. 2021;19:159–60.
Google Scholar
Qiu M, Li QT, Zhu DP, Wang CH, Sun QZ, Qian CF, et al. Efficacy observation of Maxing Xuanfei Jiedu decoction on moderate COVID-19. J Emerg Tradit Chin Med. 2020;29:1129–30.
Google Scholar
Sun HM, Xu F, Zhang L, Wei C, Chen JY, Wang QX, et al. Study on clinical efficacy of Lianhua Qingke granule in treatment of mild and ordinary COVID-19. Chin J Exp Tradit Med Formulae. 2020;26:29–34.
Google Scholar
Wang L, Xu M, Wang Y, Li HB, Liu N, Zuo JL. Clinical study on Shengmai powder combined with Shenlingbaizhu powder in the treatment of common coronavirus disease 2019. China J Tradit Chin Med Pharm. 2020;35:4268–71.
Google Scholar
Wang Y, Chen L, Zheng L, Ku BQ, Yu R, Zhang XF. Clinical effects of Qingfei Paidu decoction combined with conventional treatment on patients with coronavirus disease 2019. Chin Tradit Patent Med. 2021;43:656–9.
Google Scholar
Yu P, Li YZ, Wang SB, Wang Y. Effect of Lianhua Qingwen Granules plus abidol on treatment of mild coronavirus disease 2019. Chin Pharm J. 2020;55:1042–5.
Google Scholar
Fu XX, Lin LP, Tan XH. Clinical observation on effect of Toujie Quwen granules in treatment of COVID-19. Chin J Exp Tradit Med Formulae. 2020;26:44–8.
Google Scholar
Xiao Q, Jiang YJ, Wu SS, Wang Y, An J, Xu WP, et al. Analysis of the value of Shufeng Jiedu capsule combined with abidol in the treatment of mild coronavirus disease 2019. J Emerg Tradit Chin Med. 2020;29:756–8.
Google Scholar
Yang MB, Dang SS, Huang S, Li YJ, Guo YL. Multi-center clinical observation of Reyanning mixture in treatment of COVID-19. Chin J Exp Tradit Med Formulae. 2020;26:7–12.
Google Scholar
Zhou S, Feng J, Xie Q, Huang T, Xu X, Zhou D, et al. Traditional Chinese medicine Shenhuang granule in patients with severe/critical COVID-19: a randomized controlled multicenter trial. Phytomedicine. 2021;89:153612.
PubMed
PubMed Central
Google Scholar
Ma Q, Xie Y, Wang Z, Lei B, Chen R, Liu B, et al. Efficacy and safety of ReDuNing injection as a treatment for COVID-19 and its inhibitory effect against SARS-CoV-2. J Ethnopharmacol. 2021;279:114367.
CAS
PubMed
PubMed Central
Google Scholar
Ni L, Wen Z, Hu X, Tang W, Wang H, Zhou L, et al. Effects of Shuanghuanglian oral liquids on patients with COVID-19: a randomized, open-label, parallel-controlled, multicenter clinical trial. Front Med. 2021;15:704–17.
PubMed
PubMed Central
Google Scholar
Wang JB, Wang ZX, Jing J, Zhao P, Dong JH, Zhou YF, et al. Exploring an integrative therapy for treating COVID-19: a randomized controlled trial. Chin J Integr Med. 2020;26:648–55.
CAS
PubMed
Google Scholar
Xu X, Zhang J, Zheng W, Yang Z, Zhao X, Wang C, et al. Efficacy and safety of reduning injection in the treatment of COVID-19: a randomized, multicenter clinical study. Ann Palliat Med. 2021;10:5146–55.
PubMed
Google Scholar
Hu K, Guan WJ, Bi Y, Zhang W, Li L, Zhang B, et al. Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: a multicenter, prospective, randomized controlled trial. Phytomedicine. 2021;85:153242.
CAS
PubMed
Google Scholar
Ai XY, Luo C, Lin LP, Xie M, Fang HM, Tan XH. Therapeutic effect of integrated traditional Chinese and western medicine on COVID-19 in Guangzhou. China Trop Med. 2020;20:746–50.
Google Scholar
Wang LQ, Li WN, Huang W, Zhou ZM, Deng YL, Hu YL, et al. Clinical study of Gegen Qinlian pill in treating COVID-19. Mod Tradit Chin Med Materia Medica World Sci Technol. 2020;22:3509–14.
Google Scholar
Zheng ZZ, Bai ZG, Li CJ, Ge SP, Luo Y, He GD. Observation on the effect of TCM syndrome differentiation and treatment for COVID-19. Med J Commun. 2020;34:117–8.
Google Scholar
Ding XJ, Zhang Y, He DC, Zhang MY, Tan YJ, Yu AR, et al. Clinical effect and mechanism of Qingfei Touxie Fuzheng recipe in the treatment of COVID-19. Herald of Medicine. 2020;39:640–4.
Google Scholar
Liao GR. Efficacy and safety of Chinese herbal decoction in patients with COVID-19. Int Inf Dis. 2020;9:353.
Google Scholar
Zheng WJ, Guan JW. Clinical observation of sodium tanshinone ii A sulfonate in the treatment of COVID-19. World Latest Med Inf. 2020;20:267–8.
Google Scholar
Shi SF, Fang ZY, Xiong K, Ye DL, Wang WM, Wu H, et al. Clinical studies of comprehensive TCM treatment to 30 cases of Qi Yin deficiency type of COVID-19 in its recovery period. Jiangsu J Tradit Chin Med. 2021;53:25–8.
Google Scholar
Zhao F, Yang Z, Liu SX, Lv WZ, Lv SX, Mao MH, et al. Clinical study of Xuanfei Dayu decoction in treating the recovery stage of COVID-19. Shaanxi J Tradit Chin Med. 2020;41:846–8.
Google Scholar
Tian J, Yan S, Wang H, Zhang Y, Zheng Y, Wu H, et al. Hanshiyi formula, a medicine for Sars-CoV2 infection in China, reduced the proportion of mild and moderate COVID-19 patients turning to severe status: a cohort study. Pharmacol Res. 2020;161:105127.
CAS
PubMed
PubMed Central
Google Scholar
Xin S, Cheng X, Zhu B, Liao X, Yang F, Song L, et al. Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment. Biomed Pharmacother. 2020;129:110500.
CAS
PubMed
PubMed Central
Google Scholar
Zhang HT, Huang MX, Liu X, Zheng XC, Li XH, Chen GQ, et al. Evaluation of the adjuvant efficacy of natural herbal medicine on COVID-19: a retrospective matched case-control study. Am J Chin Med. 2020;48:779–92.
CAS
PubMed
Google Scholar
Zhang X, Xue Y, Chen X, Wu JM, Su ZJ, Sun M, et al. Effects of Tanreqing Capsule on the negative conversion time of nucleic acid in patients with COVID-19: a retrospective cohort study. J Integr Med. 2021;19:36–41.
PubMed
Google Scholar
Liu L, Shi F, Tu P, Chen C, Zhang M, Li X, et al. Arbidol combined with the Chinese medicine Lianhuaqingwen capsule versus arbidol alone in the treatment of COVID-19. Medicine. 2021;100:e24475.
CAS
PubMed
PubMed Central
Google Scholar
Shen P, Li J, Tu S, Wu Y, Peng Y, Chen G, et al. Positive effects of Lianhuaqingwen granules in COVID-19 patients: a retrospective study of 248 cases. J Ethnopharmacol. 2021;278:114220.
CAS
PubMed
PubMed Central
Google Scholar
Chen J, Lin S, Niu C, Xiao Q. Clinical evaluation of Shufeng Jiedu Capsules combined with umifenovir (arbidol) in the treatment of common-type COVID-19: a retrospective study. Expert Rev Respir Med. 2021;15:257–65.
CAS
PubMed
Google Scholar
Cheng DZ, Wang WJ, Li Y, Wu XD, Zhou B, Song QY. Analysis of curative effect of 51 patients with novel coronavirus pneumonia treated with Chinese medicine Lianhua Qingwen: a multicenter retrospective study. Tianjin J Tradit Chin Med. 2020;37:509–16.
Google Scholar
Ji D, Feng P, Fei XY. Retrospective study of clinical efficacy of integrated traditional Chinese and western medicine in treatment of COVID-19. Shandong J Tradit Chin Med. 2020;39:645–7.
Google Scholar
Yu HY, Ren XH, Qi XX, Zuo Q, Liu D. Efficacy study of Abidol, Qingfei Paidu decoction, Lianhua Qingwen capsule and Jinye Baidu granule in the treatment of mild/moderate COVID-19 in a Fangcang shelter hospital. Pharmacol Clin Chin Materia Medica. 2020;36:2–6.
Google Scholar
Yao KT, Liu MY, Li X, Huang JH, Cai HB. Retrospective clinical analysis on treatment of coronavirus disease 2019 with traditional Chinese medicine Lianhua Qingwen. Chin J Exp Tradit Med Formulae. 2020;26:8–12.
Google Scholar
Zhai XK, Hao SL, Ma JH, Wei GY, Song KY, Tang C, et al. Observation on clinical effect of Shufeng Jiedu capsule combined with abidol hydrochloride in treatment of COVID-19. Chin Tradit Herbal Drugs. 2020;51:1167–70.
Google Scholar
Sun QG, An XD, Xie P, Jiang B, Tian JX, Yang Q, et al. Traditional Chinese medicine decoctions significantly reduce the mortality in severe and critically ill patients with COVID-19: a retrospective cohort study. Am J Chin Med. 2021;49:1063–92.
CAS
PubMed
Google Scholar
Wang Y, Lu C, Li H, Qi W, Ruan L, Bian Y, et al. Efficacy and safety assessment of severe COVID-19 patients with Chinese medicine: A retrospective case series study at early stage of the COVID-19 epidemic in Wuhan, China. J Ethnopharmacol. 2021;277:113888.
CAS
PubMed
PubMed Central
Google Scholar
Chen G, Su W, Yang J, Luo D, Xia P, Jia W, et al. Chinese herbal medicine reduces mortality in patients with severe and critical Coronavirus disease 2019: a retrospective cohort study. Front Med. 2020;14:752–9.
PubMed
PubMed Central
Google Scholar
Feng J, Fang B, Zhou D, Wang J, Zou D, Yu G, et al. Clinical effect of traditional Chinese medicine Shenhuang granule in critically ill patients with COVID-19: a single-centered, retrospective, observational study. J Microbiol Biotechnol. 2021;31:380–6.
CAS
PubMed
Google Scholar
Hu H, Wang K, Wang L, Du Y, Chen J, Li Y, et al. He-Jie-Shen-Shi decoction as an adjuvant therapy on severe coronavirus disease 2019: a retrospective cohort and potential mechanistic study. Front Pharmacol. 2021;12:700498.
CAS
PubMed
PubMed Central
Google Scholar
Yang Q, Sun QG, Jiang B, Xu HJ, Luo M, Xie P, et al. Retrospective clinical study on treatment of COVID-19 patients with integrated traditional Chinese and western medicine. Chin Tradit Herb Drugs. 2020;51:2050–4.
Google Scholar
Chen L, Zhang A, Li QT, Cui Y, Yuan GD. Evaluation of clinical value of Xuebijing combined with human immunoglobulin in severe and critically ill patients with coronavirus disease 2019. Chin Crit Care Med. 2021;33:399–404.
CAS
Google Scholar
Shu Z, Chang K, Zhou Y, Peng C, Li X, Cai W, et al. Add-on Chinese medicine for Coronavirus Disease 2019 (ACCORD): a retrospective cohort study of hospital registries. Am J Chin Med. 2021;49:543–75.
CAS
PubMed
Google Scholar
Zhang L, Zheng X, Bai X, Wang Q, Chen B, Wang H, et al. Association between use of Qingfei Paidu Tang and mortality in hospitalized patients with COVID-19: a national retrospective registry study. Phytomedicine. 2021;85:153531.
CAS
PubMed
PubMed Central
Google Scholar
Ai Z, Zhou S, Li W, Wang M, Wang L, Hu G, et al. “Fei Yan No. 1” as a combined treatment for COVID-19: an efficacy and potential mechanistic study. Front Pharmacol. 2020;11:581277.
CAS
PubMed
PubMed Central
Google Scholar
Hu YQ, Lu JQ, Huang J, Huang QH, Jin HH, Ma YT, et al. Clinical observation of 31 cases with COVID-19 treated with Guizhi Erchen decoction based on triple-Jiao sequential therapy. Chin Arch Tradit Chin Med. 2020;38:1–5.
Google Scholar
Lian J, Zhang ShJ, Li GL, Shang D, Wang QY, Xu LS, et al. Retrospective analysis of 38 cases with coronavirus disease 2019 treated by integrated traditional Chinese and western medicine. J Tradit Chin Med. 2020;61:2126–30.
Google Scholar
Wang LQ, Hu GM, Ba YM, He CX, Li WN, Zhang X. A retrospective study on the treatment of coronavirus disease 2019 with “Pneumonia No. 1” combined with conventional western medicine. J Emerg Tradit Chin Med. 2021;30:10–2.
Google Scholar
Shi J, Yang ZG, Ye C, Chen SS, Lu YF, Lv Y, et al. Clinical observation on 49 cases of non-critical COVID-19 in Shanghai treated by integrated traditional Chinese and western medicine. Shanghai J Tradit Chin Med. 2020;54:30–5.
Google Scholar
Xia WG, An CQ, Zheng QJ, Zhang JX, Huang M, Wang Y, et al. Clinical observation on 34 patients with novel coronavirus pneumonia (COVID-19) treated with integrated traditional Chinese and western medicine. J Tradit Chin Med. 2020;61:375–82.
Google Scholar
An YW, Yuan B, Wang JC, Wang C, Liu TT, Song S, et al. Clinical characteristics and impacts of traditional Chinese medicine treatment on the convalescents of COVID-19. Int J Med Sci. 2021;18:646–51.
CAS
PubMed
PubMed Central
Google Scholar
Shen X, Yin F. The mechanisms and clinical application of Traditional Chinese Medicine Lianhua-Qingwen capsule. Biomed Pharmacother. 2021;142:111998.
CAS
PubMed
PubMed Central
Google Scholar
Huang K, Zhang P, Zhang Z, Youn JY, Wang C, Zhang H, et al. Traditional Chinese Medicine (TCM) in the treatment of COVID-19 and other viral infections: efficacies and mechanisms. Pharmacol Ther. 2021;225:107843.
CAS
PubMed
PubMed Central
Google Scholar
Xia J, Rong L, Sawakami T, Inagaki Y, Song P, Hasegawa K, et al. Shufeng Jiedu Capsule and its active ingredients induce apoptosis, inhibit migration and invasion, and enhances doxorubicin therapeutic efficacy in hepatocellular carcinoma. Biomed Pharmacother. 2018;99:921–30.
CAS
PubMed
Google Scholar
Ma Q, Xie Y, Wang Z, Lei B, Chen R, Liu B, et al. Efficacy and safety of ReDuNing injection as a treatment for COVID-19 and its inhibitory effect against SARS-CoV-2. J Ethnopharmacol. 2021;28(279):114367.
Google Scholar
Tao Q, Du J, Li X, Zeng J, Tan B, Xu J, et al. Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19. Drug Dev Ind Pharm. 2020;46:1345–53.
CAS
PubMed
PubMed Central
Google Scholar
Xia QD, Xun Y, Lu JL, Lu YC, Yang YY, Zhou P, et al. Network pharmacology and molecular docking analyses on Lianhua Qingwen capsule indicate Akt1 is a potential target to treat and prevent COVID-19. Cell Prolif. 2020;53:e12949.
CAS
PubMed
PubMed Central
Google Scholar
Chen J, Wang YK, Gao Y, Hu LS, Yang JW, Wang JR, et al. Protection against COVID-19 injury by qingfei paidu decoction via anti-viral, anti-inflammatory activity and metabolic programming. Biomed Pharmacother. 2020;129:110281.
CAS
PubMed
PubMed Central
Google Scholar
Mu C, Sheng Y, Wang Q, Amin A, Li X, Xie Y. Potential compound from herbal food of Rhizoma Polygonati for treatment of COVID-19 analyzed by network pharmacology: viral and cancer signaling mechanisms. J Funct Foods. 2021;77:104149.
CAS
PubMed
Google Scholar
Gao LQ, Xu J, Chen SD. In silico screening of potential Chinese herbal medicine against COVID-19 by targeting SARS-CoV-2 3CLpro and angiotensin converting enzyme II using molecular docking. Chin J Integr Med. 2020;26:527–32.
CAS
PubMed
PubMed Central
Google Scholar
Ge C, He Y. In silico prediction of molecular targets of astragaloside IV for alleviation of COVID-19 hyperinflammation by systems network pharmacology and bioinformatic gene expression analysis. Front Pharmacol. 2020;11:556984.
CAS
PubMed
PubMed Central
Google Scholar
Li X, Lin H, Wang Q, Cui L, Luo H, Luo L. Chemical composition and pharmacological mechanism of shenfu decoction in the treatment of novel coronavirus pneumonia (COVID-19). Drug Dev Ind Pharm. 2020;46:1947–59.
CAS
PubMed
Google Scholar
Ye M, Luo G, Ye D, She M, Sun N, Lu YJ, et al. Network pharmacology, molecular docking integrated surface plasmon resonance technology reveals the mechanism of Toujie Quwen Granules against coronavirus disease 2019 pneumonia. Phytomedicine. 2021;85:153401.
CAS
PubMed
Google Scholar
Li X, Qiu Q, Li M, Lin H, Cao S, Wang Q, et al. Chemical composition and pharmacological mechanism of ephedra-glycyrrhiza drug pair against coronavirus disease 2019 (COVID-19). Aging. 2021;13:4811–30.
CAS
PubMed
PubMed Central
Google Scholar
Wu H, Gong K, Qin Y, Yuan Z, Xia S, Zhang S, et al. In silico analysis of the potential mechanism of a preventive Chinese medicine formula on coronavirus disease 2019. J Ethnopharmacol. 2021;275:114098.
CAS
PubMed
PubMed Central
Google Scholar
Wang H, Zhang J, Lu Z, Dai W, Ma C, Xiang Y, et al. Identification of potential therapeutic targets and mechanisms of COVID-19 through network analysis and screening of chemicals and herbal ingredients. Brief Bioinform. 2021;23(1):bbab373.
Google Scholar
Cai Y, Zeng M, Chen YZ. The pharmacological mechanism of Huashi Baidu Formula for the treatment of COVID-19 by combined network pharmacology and molecular docking. Ann Palliat Med. 2021;10:3864–95.
PubMed
Google Scholar
Wang J, Ge W, Peng X, Yuan L, He S, Fu X. Investigating the active compounds and mechanism of HuaShi XuanFei formula for prevention and treatment of COVID-19 based on network pharmacology and molecular docking analysis. Mol Divers. 2021. https://doi.org/10.1007/s11030-021-10244-0.
Article
PubMed
PubMed Central
Google Scholar
Xiao Z, Ye Q, Duan X, Xiang T. Network pharmacology reveals that resveratrol can alleviate COVID-19-related hyperinflammation. Dis Markers. 2021;2021:4129993.
PubMed
PubMed Central
Google Scholar
Li Y, Chu F, Li P, Johnson N, Li T, Wang Y, et al. Potential effect of Maxing Shigan decoction against coronavirus disease 2019 (COVID-19) revealed by network pharmacology and experimental verification. J Ethnopharmacol. 2021;271:113854.
CAS
PubMed
PubMed Central
Google Scholar
Du HX, Zhu JQ, Chen J, Zhou HF, Yang JH, Wan HT. Revealing the therapeutic targets and molecular mechanisms of emodin-treated coronavirus disease 2019 via a systematic study of network pharmacology. Aging. 2021;13:14571–89.
CAS
PubMed
PubMed Central
Google Scholar
Niu WH, Wu F, Cao WY, Wu ZG, Chao YC, Liang C. Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6. Biosci Rep. 2021;41:BSR20202583.
CAS
PubMed
PubMed Central
Google Scholar
Ren X, Shao XX, Li XX, Jia XH, Song T, Zhou WY, et al. Identifying potential treatments of COVID-19 from Traditional Chinese Medicine (TCM) by using a data-driven approach. J Ethnopharmacol. 2020;258:112932.
CAS
PubMed
PubMed Central
Google Scholar
Xing Y, Hua YR, Shang J, Ge WH, Liao J. Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 2019. Chin J Nat Med. 2020;18:941–51.
PubMed
PubMed Central
Google Scholar
Ruan X, Du P, Zhao K, Huang J, Xia H, Dai D, et al. Mechanism of Dayuanyin in the treatment of coronavirus disease 2019 based on network pharmacology and molecular docking. Chin Med. 2020;15:62.
CAS
PubMed
PubMed Central
Google Scholar
Pan B, Fang S, Zhang J, Pan Y, Liu H, Wang Y, et al. Chinese herbal compounds against SARS-CoV-2: puerarin and quercetin impair the binding of viral S-protein to ACE2 receptor. Comput Struct Biotechnol J. 2020;18:3518–27.
CAS
PubMed
PubMed Central
Google Scholar
Gao K, Song YP, Song A. Exploring active ingredients and function mechanisms of Ephedra-bitter almond for prevention and treatment of Corona virus disease 2019 (COVID-19) based on network pharmacology. BioData Min. 2020;13:19.
CAS
PubMed
PubMed Central
Google Scholar
Yu MX, Song X, Ma XQ, Hao CX, Huang JJ, Yang WH. Investigation into molecular mechanisms and high-frequency core TCM for pulmonary fibrosis secondary to COVID-19 based on network pharmacology and data mining. Ann Palliat Med. 2021;10:3960–75.
PubMed
Google Scholar
Benton DJ, Wrobel AG, Xu P, Roustan C, Martin SR, Rosenthal PB, et al. Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion. Nature. 2020;588:327–30.
CAS
PubMed
PubMed Central
Google Scholar
Chan KK, Dorosky D, Sharma P, Abbasi SA, Dye JM, Kranz DM, et al. Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2. Science. 2020;369:1261–5.
CAS
PubMed
PubMed Central
Google Scholar
Zhang L, Lin D, Sun X, Curth U, Drosten C, Sauerhering L, et al. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors. Science. 2020;368:409–12.
CAS
PubMed
PubMed Central
Google Scholar
Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, et al. Structure of the RNA-dependent RNA polymerase from COVID-19 virus. Science. 2020;368:779–82.
CAS
PubMed
PubMed Central
Google Scholar
Rut W, Lv Z, Zmudzinski M, Patchett S, Nayak D, Snipas SJ, et al. Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: a framework for anti-COVID-19 drug design. Sci Adv. 2020;6:eabd4596.
CAS
PubMed
PubMed Central
Google Scholar
Robson F, Khan KS, Le TK, Paris C, Demirbag S, Barfuss P, et al. Coronavirus RNA proofreading: molecular basis and therapeutic targeting. Mol Cell. 2020;79:710–27.
CAS
PubMed
PubMed Central
Google Scholar
Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ, et al. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet. 2020;395:1033–4.
CAS
PubMed
PubMed Central
Google Scholar
Garbers C, Heink S, Korn T, Rose-John S. Interleukin-6: designing specific therapeutics for a complex cytokine. Nat Rev Drug Discov. 2018;17:395–412.
CAS
PubMed
Google Scholar
Jones HD, Crother TR, Gonzalez-Villalobos RA, Jupelli M, Chen S, Dagvadorj J, et al. The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. Am J Respir Cell Mol Biol. 2014;50:270–80.
PubMed
PubMed Central
Google Scholar
Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, et al. MK2 phosphorylates RIPK1 to prevent TNF-induced cell death. Mol Cell. 2017;66:698–710.
CAS
PubMed
PubMed Central
Google Scholar
Jordan S, Tung N, Casanova-Acebes M, Chang C, Cantoni C, Zhang D, et al. Dietary intake regulates the circulating inflammatory monocyte pool. Cell. 2019;178:1102–14.
CAS
PubMed
PubMed Central
Google Scholar
Ramasamy S, Subbian S. Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis. Clin Microbiol Rev. 2021;34:e00299.
CAS
PubMed
PubMed Central
Google Scholar
Dai W, Bi J, Li F, Wang S, Huang X, Meng X, et al. Antiviral efficacy of flavonoids against enterovirus 71 infection in vitro and in newborn mice. Viruses. 2019;11:625.
CAS
PubMed Central
Google Scholar
Tutunchi H, Naeini F, Ostadrahimi A, Hosseinzadeh-Attar MJ. Naringenin, a flavanone with antiviral and anti-inflammatory effects: a promising treatment strategy against COVID-19. Phytother Res. 2020;34:3137–47.
CAS
PubMed
Google Scholar
Dai SJ, Ren Y, Shen L, Zhang DW. New alkaloids from Forsythia suspensa and their anti-inflammatory activities. Planta Med. 2009;75:375–7.
CAS
PubMed
Google Scholar
Hsu DZ, Liu MY. Bicuculline methiodide attenuates hepatic injury and decreases mortality in septic rats: role of cytokines. Shock. 2004;22:347–50.
CAS
PubMed
Google Scholar
Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, et al. Quercetin, inflammation and immunity. Nutrients. 2016;8:167.
PubMed
PubMed Central
Google Scholar
Li Y, Meng T, Hao N, Tao H, Zou S, Li M, et al. Immune regulation mechanism of Astragaloside IV on RAW264.7 cells through activating the NF-kappaB/MAPK signaling pathway. Int Immunopharmacol. 2017;49:38–49.
CAS
PubMed
Google Scholar
Kim B, Kim YS, Hwang YH, Yang HJ, Li W, Kwon EB, et al. Quercus acuta Thunb. (Fagaceae) and its component, isoquercitrin, inhibit HSV-1 replication by suppressing virus-induced ROS production and NF-kappaB activation. Antioxidants. 2021;10:1638.
CAS
PubMed
PubMed Central
Google Scholar
Ninfali P, Antonelli A, Magnani M, Scarpa ES. Antiviral properties of flavonoids and delivery strategies. Nutrients. 2020;12:2534.
CAS
PubMed Central
Google Scholar
Bai SK, Lee SJ, Na HJ, Ha KS, Han JA, Lee H, et al. beta-Carotene inhibits inflammatory gene expression in lipopolysaccharide-stimulated macrophages by suppressing redox-based NF-kappaB activation. Exp Mol Med. 2005;37:323–34.
CAS
PubMed
Google Scholar
Leu WJ, Chen JC, Guh JH. Extract from Plectranthus amboinicus inhibit maturation and release of interleukin 1beta through inhibition of NF-kappaB nuclear translocation and NLRP3 inflammasome activation. Front Pharmacol. 2019;10:573.
CAS
PubMed
PubMed Central
Google Scholar
Lai JL, Liu YH, Liu C, Qi MP, Liu RN, Zhu XF, et al. Indirubin inhibits LPS-induced inflammation via TLR4 abrogation mediated by the NF-kB and MAPK signaling pathways. Inflammation. 2017;40:1–12.
CAS
PubMed
Google Scholar
Sithisarn P, Michaelis M, Schubert-Zsilavecz M, Cinatl J Jr. Differential antiviral and anti-inflammatory mechanisms of the flavonoids biochanin A and baicalein in H5N1 influenza A virus-infected cells. Antiviral Res. 2013;97:41–8.
CAS
PubMed
Google Scholar
Ma R, Yuan F, Wang S, Liu Y, Fan T, Wang F. Calycosin alleviates cerulein-induced acute pancreatitis by inhibiting the inflammatory response and oxidative stress via the p38 MAPK and NF-kappaB signal pathways in mice. Biomed Pharmacother. 2018;105:599–605.
CAS
PubMed
Google Scholar
Sertie JA, Basile AC, Panizza S, Matida AK, Zelnik R. Anti-inflammatory activity and sub-acute toxicity of artemetin. Planta Med. 1990;56:36–40.
CAS
PubMed
Google Scholar
Chu Y, Lv X, Zhang L, Fu X, Song S, Su A, et al. Wogonin inhibits in vitro herpes simplex virus type 1 and 2 infection by modulating cellular NF-kappaB and MAPK pathways. BMC Microbiol. 2020;20:227.
CAS
PubMed
PubMed Central
Google Scholar
Shrimali D, Shanmugam MK, Kumar AP, Zhang J, Tan BK, Ahn KS, et al. Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer. Cancer Lett. 2013;341:139–49.
CAS
PubMed
Google Scholar
He S, Tian J, Li X, Zhou Y, Xiao M, Zhang Y, et al. Positive RT-PCR test results in 420 patients recovered from COVID-19 in Wuhan: an observational study. Front Pharmacol. 2020;11:549117.
CAS
PubMed
PubMed Central
Google Scholar