Fig. 8

Schematic illustration of the mechanism by which the down-regulation of lncRNA Miat by electroacupuncture protects against myocardial fibrosis. The injection of ISO can lead to the occurrence of myocardial fibrosis and increase the expression level of Miat, which can adsorb miR-133a-3p as a sponge and increase the expression level of the CTGF protein. Miat can also be used as decoy to promote the separation of the heterodimer PPARG/RXRA and improve the transcription of TGF-β1, thus causing myocardial fibrosis. Electroacupuncture PC6 can inhibit the expression of Miat and inhibit myocardial fibrosis