Al-Mustanjid M, Mahmud SMH, Royel MRI, Rahman MH, Islam T, Rahman MR, et al. Detection of molecular signatures and pathways shared in inflammatory bowel disease and colorectal cancer: a bioinformatics and systems biology approach. Genomics. 2020;112(5):3416–26.
Article
CAS
PubMed
Google Scholar
Ibrahim S, Zhu X, Luo X, Feng Y, Wang J. PIK3R3 regulates ZO-1 expression through the NF-kB pathway in inflammatory bowel disease. Int Immunopharmacol. 2020;85: 106610.
Article
CAS
PubMed
Google Scholar
Linson EA, Hanauer SB. Epidemiology of colorectal cancer in inflammatory bowel disease—the evolving landscape. Curr Gastroenterol Rep. 2021;23(9):16.
Article
PubMed
Google Scholar
Zeeshan M, Ali H, Khan S, Khan SA, Weigmann B. Advances in orally-delivered pH-sensitive nanocarrier systems; an optimistic approach for the treatment of inflammatory bowel disease. Int J Pharm. 2019;558:201–14.
Article
CAS
PubMed
Google Scholar
Li H. Advances in anti hepatic fibrotic therapy with traditional Chinese medicine herbal formula. J Ethnopharmacol. 2020;251: 112442.
Article
CAS
PubMed
Google Scholar
Luan X, Zhang LJ, Li XQ, Rahman K, Zhang H, Chen HZ, et al. Compound-based Chinese medicine formula: from discovery to compatibility mechanism. J Ethnopharmacol. 2020;254: 112687.
Article
CAS
PubMed
Google Scholar
Gao W, Zhang L, Wang X, Yu L, Wang C, Gong Y. The combination of indirubin and isatin attenuates dextran sodium sulfate induced ulcerative colitis in mice. Biochem Cell Biol. 2018;96(5):636–45.
Article
CAS
PubMed
Google Scholar
Huang C, Dong J, Jin X, Ma H, Zhang D, Wang F, et al. Intestinal anti-inflammatory effects of fuzi-ganjiang herb pair against DSS-induced ulcerative colitis in mice. J Ethnopharmacol. 2020;261: 112951.
Article
CAS
PubMed
Google Scholar
Tang S, Liu W, Zhao Q, Li K, Zhu J, Yao W, et al. Combination of polysaccharides from Astragalus membranaceus and Codonopsis pilosula ameliorated mice colitis and underlying mechanisms. J Ethnopharmacol. 2021;264: 113280.
Article
CAS
PubMed
Google Scholar
Epple HJ, Zeitz M. HIV infection and the intestinal mucosal barrier. Ann N Y Acad Sci. 2012;1258:19–24.
Article
CAS
PubMed
Google Scholar
Lee SH. Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases. Intest Res. 2015;13(1):11–8.
Article
PubMed
PubMed Central
Google Scholar
Takizawa Y, Kishimoto H, Tomita M, Hayashi M. Changes in the expression levels of tight junction components during reconstruction of tight junction from mucosal lesion by intestinal ischemia/reperfusion. Eur J Drug Metab Pharmacokinet. 2014;39(3):211–20.
Article
CAS
PubMed
Google Scholar
Lin JC, Wu JQ, Wang F, Tang FY, Sun J, Xu B, et al. QingBai decoction regulates intestinal permeability of dextran sulphate sodium-induced colitis through the modulation of notch and NF-kappaB signalling. Cell Prolif. 2019;52(2): e12547.
Article
PubMed
PubMed Central
CAS
Google Scholar
Yuan Z, Yang L, Zhang X, Ji P, Hua Y, Wei Y. Huang-Lian-Jie-Du decoction ameliorates acute ulcerative colitis in mice via regulating NF-kappaB and Nrf2 signaling pathways and enhancing intestinal barrier function. Front Pharmacol. 2019;10:1354.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zou Y, Lin J, Li W, Wu Z, He Z, Huang G, et al. Huangqin-tang ameliorates dextran sodium sulphate-induced colitis by regulating intestinal epithelial cell homeostasis, inflammation and immune response. Sci Rep. 2016;6:39299.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fang W, Zhao P, Shen A, Liu L, Chen H, Chen Y, et al. Effects of Qing Hua Chang Yin on lipopolysaccharide induced intestinal epithelial tight junction injury in Caco2 cells. Mol Med Rep. 2021;23(3):1.
PubMed
Google Scholar
Lu Y, Lin H, Zhang J, Wei J, Sun J, Han L. Sijunzi decoction attenuates 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats and ameliorates TNBS-induced claudin-2 damage via NF-kappaB pathway in Caco2 cells. BMC Complement Altern Med. 2017;17(1):35.
Article
PubMed
PubMed Central
CAS
Google Scholar
Rodriguez-Pineiro AM, Bergstrom JH, Ermund A, Gustafsson JK, Schutte A, Johansson ME, et al. Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins. Am J Physiol Gastrointest Liver Physiol. 2013;305(5):G348–56.
Article
CAS
PubMed
PubMed Central
Google Scholar
Albert-Bayo M, Paracuellos I, Gonzalez-Castro AM, Rodriguez-Urrutia A, Rodriguez-Lagunas MJ, Alonso-Cotoner C, et al. Intestinal mucosal mast cells: key modulators of barrier function and homeostasis. Cells. 2019;8(2):135.
Article
CAS
PubMed Central
Google Scholar
Muzes G, Tulassay Z, Sipos F. Interplay of autophagy and innate immunity in Crohn’s disease: a key immunobiologic feature. World J Gastroenterol. 2013;19(28):4447–54.
Article
PubMed
PubMed Central
CAS
Google Scholar
Wang W, Chen L, Zhou R, Wang X, Song L, Huang S, et al. Increased proportions of Bifidobacterium and the Lactobacillus group and loss of butyrate-producing bacteria in inflammatory bowel disease. J Clin Microbiol. 2014;52(2):398–406.
Article
PubMed
PubMed Central
CAS
Google Scholar
Jiang H, Qu L, Dou R, Lu L, Bian S, Zhu W. Potential role of mesenchymal stem cells in alleviating intestinal ischemia/reperfusion impairment. PLoS ONE. 2013;8(9): e74468.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang Y, Chen G, Yang Q, Ye J, Cai X, Tsering P, et al. Gut microbiota drives the attenuation of dextran sulphate sodium-induced colitis by Huangqin decoction. Oncotarget. 2017;8(30):48863–74.
Article
PubMed
PubMed Central
Google Scholar
Yuan Z, Yang L, Zhang X, Ji P, Wei Y. Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice. Biomed Pharmacother. 2020;121: 109638.
Article
CAS
PubMed
Google Scholar
Zhang Z, Cao H, Shen P, Liu J, Cao Y, Zhang N. Ping weisan alleviates chronic colitis in mice by regulating intestinal microbiota composition. J Ethnopharmacol. 2020;255: 112715.
Article
CAS
PubMed
Google Scholar
Liu P, Bian Y, Liu T, Zhong J, Zhong Y, Zhuang S, et al. Huai hua san alleviates dextran sulphate sodium-induced colitis and modulates colonic microbiota. J Ethnopharmacol. 2020;259: 112944.
Article
CAS
PubMed
Google Scholar
Yang M, Bose S, Lim SK, Kim H. Preventive effects of Pyungwi-san against dextran sulfate sodium- and Clostridium difficile-induced inflammatory bowel disease in mice. Int J Mol Sci. 2019;20(24):6346.
Article
CAS
PubMed Central
Google Scholar
Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity. 2014;40(1):128–39.
Article
CAS
PubMed
PubMed Central
Google Scholar
de Preter V. Metabolomics in the clinical diagnosis of inflammatory bowel disease. Dig Dis. 2015;33(Suppl 1):2–10.
Article
PubMed
Google Scholar
Bottcher T, Pitscheider M, Sieber SA. Natural products and their biological targets: proteomic and metabolomic labeling strategies. Angew Chem Int Ed Engl. 2010;49(15):2680–98.
Article
PubMed
CAS
Google Scholar
Dehairs J, Derua R, Rueda-Rincon N, Swinnen JV. Lipidomics in drug development. Drug Discov Today Technol. 2015;13:33–8.
Article
PubMed
Google Scholar
Hong ZC, Cai Q, Wu HZ, Yang YF, Fan H, Duan XY. Compound Sophorae decoction: treating ulcerative colitis by affecting multiple metabolic pathways. Chin J Nat Med. 2021;19(4):267–83.
CAS
PubMed
Google Scholar
Han Z, Wang H, Guo D, Zhang J. Integrative transcriptomic and metabonomic profiling analyses reveal the molecular mechanism of Chinese traditional medicine huankuile suspension on TNBS-induced ulcerative colitis. Aging. 2021;13(4):5087–103.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yuan Z, Yang L, Zhang X, Ji P, Hua Y, Wei Y. Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: regulating arachidonic acid metabolism and glycerophospholipid metabolism. J Ethnopharmacol. 2020;259: 112872.
Article
CAS
PubMed
Google Scholar
Wang D, Ma X, Guo S, Wang Y, Li T, Zou D, et al. Effect of Huangqin Tang on urine metabolic profile in rats with ulcerative colitis based on UPLC-Q-exactive orbitrap MS. Evid Based Complement Alternat Med. 2020;2020:1874065.
PubMed
PubMed Central
Google Scholar
Wang D, Shi K, Wang Y, Zou D, Guo S, Li T, et al. Effect of Huangqin Tang on colonic gene expression in rats with ulcerative colitis. Int J Genom. 2020;2020:4238757.
Google Scholar
Luo S, Wen R, Wang Q, Zhao Z, Nong F, Fu Y, et al. Rhubarb Peony decoction ameliorates ulcerative colitis in mice by regulating gut microbiota to restoring Th17/Treg balance. J Ethnopharmacol. 2019;231:39–49.
Article
CAS
PubMed
Google Scholar
Amagase K, Kimura Y, Wada A, Yukishige T, Murakami T, Nakamura E, et al. Prophylactic effect of monosodium glutamate on NSAID-induced enteropathy in rats. Curr Pharm Des. 2014;20(16):2783–90.
Article
CAS
PubMed
Google Scholar
Chen F, Yin YT, Zhao HM, Wang HY, Zhong YB, Long J, et al. Sishen pill treatment of DSS-induced colitis via regulating interaction with inflammatory dendritic cells and gut microbiota. Front Physiol. 2020;11:801.
Article
PubMed
PubMed Central
Google Scholar
Ma H, Tao W, Zhu S. T lymphocytes in the intestinal mucosa: defense and tolerance. Cell Mol Immunol. 2019;16(3):216–24.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhong YB, Kang ZP, Zhou BG, Wang HY, Long J, Zhou W, et al. Curcumin regulated the homeostasis of memory T cell and ameliorated dextran sulfate sodium-induced experimental colitis. Front Pharmacol. 2020;11: 630244.
Article
CAS
PubMed
Google Scholar
Wu B, Wan Y. Molecular control of pathogenic Th17 cells in autoimmune diseases. Int Immunopharmacol. 2020;80: 106187.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tanoue T, Atarashi K, Honda K. Development and maintenance of intestinal regulatory T cells. Nat Rev Immunol. 2016;16(5):295–309.
Article
CAS
PubMed
Google Scholar
Haase S, Haghikia A, Wilck N, Muller DN, Linker RA. Impacts of microbiome metabolites on immune regulation and autoimmunity. Immunology. 2018;154(2):230–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao Y, Luan H, Jiang H, Xu Y, Wu X, Zhang Y, et al. Gegen Qinlian decoction relieved DSS-induced ulcerative colitis in mice by modulating Th17/Treg cell homeostasis via suppressing IL-6/JAK2/STAT3 signaling. Phytomedicine. 2021;84: 153519.
Article
CAS
PubMed
Google Scholar
Zhang M, Fan H, Tan S, Tang Q, Liu X, Zuo D, et al. The Chinese medicinal herb decoction QRZSLXF enhances anti-inflammatory effect in TNBS-induced colitis via balancing Th17/Tregs differentiation. J Ethnopharmacol. 2020;251: 112549.
Article
CAS
PubMed
Google Scholar
Xu M, Duan XY, Chen QY, Fan H, Hong ZC, Deng SJ, et al. Effect of compound sophorae decoction on dextran sodium sulfate (DSS)-induced colitis in mice by regulating Th17/Treg cell balance. Biomed Pharmacother. 2019;109:2396–408.
Article
CAS
PubMed
Google Scholar
Wen J, Teng B, Yang P, Chen X, Li C, Jing Y, et al. The potential mechanism of Bawei Xileisan in the treatment of dextran sulfate sodium-induced ulcerative colitis in mice. J Ethnopharmacol. 2016;188:31–8.
Article
PubMed
Google Scholar
Liu XK, Zhao HM, Wang HY, Ge W, Zhong YB, Long J, et al. Regulatory effect of Sishen pill on Tfh cells in mice with experimental colitis. Front Physiol. 2020;11:589.
Article
CAS
PubMed
PubMed Central
Google Scholar
Waldner MJ, Neurath MF. Mechanisms of immune signaling in colitis-associated cancer. Cell Mol Gastroenterol Hepatol. 2015;1(1):6–16.
Article
PubMed
Google Scholar
Perkins ND. Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway. Oncogene. 2006;25(51):6717–30.
Article
CAS
PubMed
Google Scholar
Li F, Zhang J, Arfuso F, Chinnathambi A, Zayed ME, Alharbi SA, et al. NF-kappaB in cancer therapy. Arch Toxicol. 2015;89(5):711–31.
Article
CAS
PubMed
Google Scholar
He Z, Zhou Q, Wen K, Wu B, Sun X, Wang X, et al. Huangkui Lianchang decoction ameliorates DSS-induced ulcerative colitis in mice by inhibiting the NF-kappaB signaling pathway. Evid Based Complement Alternat Med. 2019;2019:1040847.
PubMed
PubMed Central
Google Scholar
Chen YL, Zheng YY, Dai YC, Zhang YL, Tang ZP. Systems pharmacology approach reveals protective mechanisms of Jian-Pi Qing-Chang decoction on ulcerative colitis. World J Gastroenterol. 2019;25(21):2603–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hu Z, Yang M, Ye Q, Qin K, Wu M, Gu R, et al. Tou Nong San attenuates inflammation in TNBS-IBD model by inhibiting NF-kappaB signaling pathway. Evid Based Complement Alternat Med. 2018;2018:6929307.
PubMed
PubMed Central
Google Scholar
Zheng L, Zhang YL, Dai YC, Chen X, Chen DL, Dai YT, et al. Jianpi Qingchang decoction alleviates ulcerative colitis by inhibiting nuclear factor-kappaB activation. World J Gastroenterol. 2017;23(7):1180–8.
Article
PubMed
PubMed Central
Google Scholar
Dai YC, Zheng L, Zhang YL, Chen X, Chen DL, Wang LJ, et al. Jianpi Qingchang decoction regulates intestinal motility of dextran sulfate sodium-induced colitis through reducing autophagy of interstitial cells of Cajal. World J Gastroenterol. 2017;23(26):4724–34.
Article
CAS
PubMed
PubMed Central
Google Scholar
Candia E, Diaz-Jimenez D, Langjahr P, Nunez LE, de la Fuente M, Farfan N, et al. Increased production of soluble TLR2 by lamina propria mononuclear cells from ulcerative colitis patients. Immunobiology. 2012;217(6):634–42.
Article
CAS
PubMed
Google Scholar
Frolova L, Drastich P, Rossmann P, Klimesova K, Tlaskalova-Hogenova H. Expression of Toll-like receptor 2 (TLR2), TLR4, and CD14 in biopsy samples of patients with inflammatory bowel diseases: upregulated expression of TLR2 in terminal ileum of patients with ulcerative colitis. J Histochem Cytochem. 2008;56(3):267–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li R, Chen Y, Shi M, Xu X, Zhao Y, Wu X, et al. Gegen Qinlian decoction alleviates experimental colitis via suppressing TLR4/NF-kappaB signaling and enhancing antioxidant effect. Phytomedicine. 2016;23(10):1012–20.
Article
PubMed
Google Scholar
Liu B, Piao X, Niu W, Zhang Q, Ma C, Wu T, et al. Kuijieyuan decoction improved intestinal barrier injury of ulcerative colitis by affecting TLR4-dependent PI3K/AKT/NF-kappaB oxidative and inflammatory signaling and gut microbiota. Front Pharmacol. 2020;11:1036.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhou HY, Zhu H, Yao XM, Qian JP, Yang J, Pan XD, et al. Metformin regulates tight junction of intestinal epithelial cells via MLCK-MLC signaling pathway. Eur Rev Med Pharmacol Sci. 2017;21(22):5239–46.
PubMed
Google Scholar
Xiong Y, Wang C, Shi L, Wang L, Zhou Z, Chen D, et al. Myosin light chain kinase: a potential target for treatment of inflammatory diseases. Front Pharmacol. 2017;8:292.
Article
PubMed
PubMed Central
CAS
Google Scholar
Kang X, Jia M, Zhao L, Zhang S. Bu-Zhong-Yi-Qi granule enhances colonic tight junction integrity via TLR4/NF-kappaB/MLCK signaling pathway in ulcerative colitis rats. Evid Based Complement Alternat Med. 2021;2021:6657141.
PubMed
PubMed Central
Google Scholar
Chao L, Li Z, Zhou J, Chen W, Li Y, Lv W, et al. Shen-Ling-Bai-Zhu-San improves dextran sodium sulfate-induced colitis by inhibiting caspase-1/caspase-11-mediated pyroptosis. Front Pharmacol. 2020;11:814.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wieacker P, Zimmer J, Ropers HH. X inactivation patterns in two syndromes with probable X-linked dominant, male lethal inheritance. Clin Genet. 1985;28(3):238–42.
Article
CAS
PubMed
Google Scholar
Brott BK, Pinsky BA, Erikson RL. Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus. Proc Natl Acad Sci USA. 1998;95(3):963–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ota S, Ishitani S, Shimizu N, Matsumoto K, Itoh M, Ishitani T. NLK positively regulates Wnt/beta-catenin signalling by phosphorylating LEF1 in neural progenitor cells. EMBO J. 2012;31(8):1904–15.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang HY, Zhao HM, Wang Y, Liu Y, Lu XY, Liu XK, et al. Sishen Wan((R)) ameliorated trinitrobenzene-sulfonic-acid-induced chronic colitis via NEMO/NLK signaling pathway. Front Pharmacol. 2019;10:170.
Article
PubMed
PubMed Central
CAS
Google Scholar
Li S, Wu Y, Yang D, Wu C, Ma C, Liu X, et al. Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis. J Exp Med. 2019;216(11):2562–81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhao W, He F, Barkema HW, Xu S, Gao J, Liu G, et al. Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-kappaB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures. Vet Res. 2021;52(1):144.
Article
CAS
PubMed
PubMed Central
Google Scholar
Qiao H, Huang Y, Chen X, Yang L, Wang Y, Xu R. Jiaweishaoyao decoction alleviates DSS-induced ulcerative colitis via inhibiting inflammation. Gastroenterol Res Pract. 2020;2020:7182874.
Article
PubMed
PubMed Central
Google Scholar
Zhang Z, Shen P, Xie W, Cao H, Liu J, Cao Y, et al. Pingwei San ameliorates dextran sulfate sodium-induced chronic colitis in mice. J Ethnopharmacol. 2019;236:91–9.
Article
CAS
PubMed
Google Scholar
Alkhadar H, Macluskey M, White S, Ellis I. Nerve growth factor-induced migration in oral and salivary gland tumour cells utilises the PI3K/Akt signalling pathway: is there a link to perineural invasion? J Oral Pathol Med. 2020;49(3):227–34.
Article
CAS
PubMed
Google Scholar
Gabbouj S, Ryhanen S, Marttinen M, Wittrahm R, Takalo M, Kemppainen S, et al. Altered insulin signaling in Alzheimer’s disease brain—special emphasis on PI3K-Akt pathway. Front Neurosci. 2019;13:629.
Article
PubMed
PubMed Central
Google Scholar
Zhou BG, Liu FC, Zhao HM, Zhang XY, Wang HY, Liu DY. Regulatory effect of Zuojin pill on correlation with gut microbiota and Treg cells in DSS-induced colitis. J Ethnopharmacol. 2020;262: 113211.
Article
CAS
PubMed
Google Scholar
Ge W, Wang HY, Zhao HM, Liu XK, Zhong YB, Long J, et al. Effect of Sishen pill on memory T cells from experimental colitis induced by dextran sulfate sodium. Front Pharmacol. 2020;11:908.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang B, Gong Z, Zhan J, Yang L, Zhou Q, Yuan X. Xianglian pill suppresses inflammation and protects intestinal epithelial barrier by promoting autophagy in DSS induced ulcerative colitis mice. Front Pharmacol. 2020;11: 594847.
Article
CAS
PubMed
Google Scholar
Li MY, Luo HJ, Wu X, Liu YH, Gan YX, Xu N, et al. Anti-inflammatory effects of Huangqin decoction on dextran sulfate sodium-induced ulcerative colitis in mice through regulation of the gut microbiota and suppression of the Ras-PI3K-Akt-HIF-1alpha and NF-kappaB pathways. Front Pharmacol. 2019;10:1552.
Article
CAS
PubMed
Google Scholar
Leonard WJ, O’Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol. 1998;16:293–322.
Article
CAS
PubMed
Google Scholar
Hiller J, Hagl B, Effner R, Puel A, Schaller M, Mascher B, et al. STAT1 gain-of-function and dominant negative STAT3 mutations impair IL-17 and IL-22 immunity associated with CMC. J Invest Dermatol. 2018;138(3):711–4.
Article
CAS
PubMed
Google Scholar
Li X, Wang Y, Wang K, Wu Y. Renal protective effect of paeoniflorin by inhibition of JAK2/STAT3 signaling pathway in diabetic mice. Biosci Trends. 2018;12(2):168–76.
Article
CAS
PubMed
Google Scholar
Lu Z, Xiong W, Xiao S, Lin Y, Yu K, Yue G, et al. Huanglian Jiedu decoction ameliorates DSS-induced colitis in mice via the JAK2/STAT3 signalling pathway. Chin Med. 2020;15:45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li L, Shen A, Chu J, Sferra TJ, Sankararaman S, Ke X, et al. Pien Tze Huang ameliorates DSS-induced colonic inflammation in a mouse colitis model through inhibition of the IL-6/STAT3 pathway. Mol Med Rep. 2018;18(1):1113–9.
CAS
PubMed
Google Scholar
Xuan-Qing C, Xiang-Yu LV, Shi-Jia LIU. Baitouweng decoction alleviates dextran sulfate sodium-induced ulcerative colitis by regulating intestinal microbiota and the IL-6/STAT3 signaling pathway. J Ethnopharmacol. 2021;265: 113357.
Article
CAS
PubMed
Google Scholar
Foldi J, Chung AY, Xu H, Zhu J, Outtz HH, Kitajewski J, et al. Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1. J Immunol. 2010;185(9):5023–31.
Article
CAS
PubMed
Google Scholar
Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol. 2006;7(9):678–89.
Article
CAS
PubMed
Google Scholar
Zhao Y, Luan H, Gao H, Wu X, Zhang Y, Li R. Gegen Qinlian decoction maintains colonic mucosal homeostasis in acute/chronic ulcerative colitis via bidirectionally modulating dysregulated Notch signaling. Phytomedicine. 2020;68: 153182.
Article
CAS
PubMed
Google Scholar
Wu H, Chen QY, Wang WZ, Chu S, Liu XX, Liu YJ, et al. Compound sophorae decoction enhances intestinal barrier function of dextran sodium sulfate induced colitis via regulating notch signaling pathway in mice. Biomed Pharmacother. 2021;133: 110937.
Article
CAS
PubMed
Google Scholar
Lea SR, Reynolds SL, Kaur M, Simpson KD, Hall SR, Hessel EM, et al. The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages. Int J Chron Obstruct Pulmon Dis. 2018;13:771–80.
Article
CAS
PubMed
PubMed Central
Google Scholar
Balka KR, de Nardo D. Understanding early TLR signaling through the Myddosome. J Leukoc Biol. 2019;105(2):339–51.
Article
CAS
PubMed
Google Scholar
Wang S, Guo C, Zhang T, Zhong C, Zhao X, Su Y, et al. Tiaochang Xiaoyan extract tablets ameliorate chronic inflammation by activating macrophage lysosomes in chronic colitis rats. Ann Palliat Med. 2021;10(2):2203–16.
Article
PubMed
Google Scholar
Zarling JM, Shoyab M, Marquardt H, Hanson MB, Lioubin MN, Todaro GJ. Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. Proc Natl Acad Sci USA. 1986;83(24):9739–43.
Article
CAS
PubMed
PubMed Central
Google Scholar
Verstockt S, Verstockt B, Machiels K, Vancamelbeke M, Ferrante M, Cleynen I, et al. Oncostatin M is a biomarker of diagnosis, worse disease prognosis, and therapeutic nonresponse in inflammatory bowel disease. Inflamm Bowel Dis. 2021;27(10):1564–75.
Article
PubMed
PubMed Central
Google Scholar
Li Y, Chen F, Xie Y, Yang Q, Luo H, Jia P, et al. Feiyangchangweiyan capsule protects against ulcerative colitis in mice by modulating the OSM/OSMR pathway and improving gut microbiota. Phytomedicine. 2021;80: 153372.
Article
CAS
PubMed
Google Scholar
Corr M. Wnt signaling in ankylosing spondylitis. Clin Rheumatol. 2014;33(6):759–62.
Article
PubMed
Google Scholar
Sharma M, Castro-Piedras I, Simmons GE Jr, Pruitt K. Dishevelled: a masterful conductor of complex Wnt signals. Cell Signal. 2018;47:52–64.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhu H, Li YR. Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence. Exp Biol Med. 2012;237(5):474–80.
Article
CAS
Google Scholar
Wu ZC, Zhao ZL, Deng JP, Huang JT, Wang YF, Wang ZP. Sanhuang Shu’ai decoction alleviates DSS-induced ulcerative colitis via regulation of gut microbiota, inflammatory mediators and cytokines. Biomed Pharmacother. 2020;125: 109934.
Article
CAS
PubMed
Google Scholar
Gao H, Li Y, Sun J, Xu H, Wang M, Zuo X, et al. Saccharomyces boulardii ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating NF-kappaB and Nrf2 signaling pathways. Oxid Med Cell Longev. 2021;2021:1622375.
PubMed
PubMed Central
Google Scholar
Li J, Ichikawa T, Janicki JS, Cui T. Targeting the Nrf2 pathway against cardiovascular disease. Expert Opin Ther Targets. 2009;13(7):785–94.
Article
CAS
PubMed
Google Scholar
He M, Pan H, Chang RC, So KF, Brecha NC, Pu M. Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage. PLoS ONE. 2014;9(1): e84800.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhang J, Kang X, Sun M, Zhang S. Qingre Jianpi decoction attenuates inflammatory responses by suppressing NOD-like receptor family pyrin domain-containing 3 inflammasome activation in dextran sulfate sodium-induced colitis mice. J Tradit Chin Med. 2021;41(1):68–78.
PubMed
Google Scholar
Yu T, Li Z, Xu L, Yang M, Zhou X. Anti-inflammation effect of Qingchang suppository in ulcerative colitis through JAK2/STAT3 signaling pathway in vitro and in vivo. J Ethnopharmacol. 2021;266: 113442.
Article
CAS
PubMed
Google Scholar
Shao J, Liu Z, Wang L, Song Z, Chang H, Han N, et al. Screening of the optimized prescription from Suqingwan in terms of its therapeutic effect on DSS-induced ulcerative colitis by its regulation of inflammatory and oxidative mediators. J Ethnopharmacol. 2017;202:54–62.
Article
PubMed
Google Scholar
Liu B, Liu T, Wang X, Zheng X, Wang H, Ma L. Effects of Guchang capsule on dextran sulphate sodium-induced experimental ulcerative colitis in mice. Evid Based Complement Alternat Med. 2016;2016:3150651.
PubMed
PubMed Central
Google Scholar
Wang R, Wu G, Du L, Shao J, Liu F, Yang Z, et al. Semi-bionic extraction of compound turmeric protects against dextran sulfate sodium-induced acute enteritis in rats. J Ethnopharmacol. 2016;190:288–300.
Article
CAS
PubMed
Google Scholar
Wang X, Fan F, Cao Q. Modified Pulsatilla decoction attenuates oxazolone-induced colitis in mice through suppression of inflammation and epithelial barrier disruption. Mol Med Rep. 2016;14(2):1173–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen YL, Zhang YL, Dai YC, Tang ZP. Systems pharmacology approach reveals the antiinflammatory effects of Ampelopsis grossedentata on dextran sodium sulfate-induced colitis. World J Gastroenterol. 2018;24(13):1398–409.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang W, Chao X, Wu JQ, Ma XB, Yang YL, Wu Y, et al. Exploring the potential mechanism of Guchang Zhixie Wan for treating ulcerative colitis by comprehensive network pharmacological approaches and molecular docking validation as well as cell experiments. Chem Biodivers. 2021;18(1): e2000810.
CAS
PubMed
Google Scholar
Jimbo K, Ohtsuka Y, Kojima Y, Hosoi K, Ohbayashi N, Ikuse T, et al. Increased expression of CXCR3 axis components and matrix metalloproteinase in pediatric inflammatory bowel disease patients. Pediatr Int. 2014;56(6):873–83.
Article
CAS
PubMed
Google Scholar
Liu M, Guo S, Hibbert JM, Jain V, Singh N, Wilson NO, et al. CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications. Cytokine Growth Factor Rev. 2011;22(3):121–30.
CAS
PubMed
PubMed Central
Google Scholar
Mao TY, Shi R, Zhao WH, Guo Y, Gao KL, Chen C, et al. Qingchang Wenzhong decoction ameliorates dextran sulphate sodium-induced ulcerative colitis in rats by downregulating the IP10/CXCR3 axis-mediated inflammatory response. Evid Based Complement Alternat Med. 2016;2016:4312538.
PubMed
PubMed Central
Google Scholar
Kreida S, Roche JV, Olsson C, Linse S, Tornroth-Horsefield S. Protein–protein interactions in AQP regulation—biophysical characterization of AQP0-CaM and AQP2-LIP5 complex formation. Faraday Discuss. 2018;209:35–54.
Article
CAS
PubMed
Google Scholar
Benga G. Water channel proteins (later called aquaporins) and relatives: past, present, and future. IUBMB Life. 2009;61(2):112–33.
Article
CAS
PubMed
Google Scholar
Pan X, Xu K, Xiong R, Chen ZM, Hu CJ, Feng J, et al. Therapeutic effect of Ershen pill () extract on Pi (spleen)-Shen (kidney) yang deficiency-induced diarrhea in rat model. Chin J Integr Med. 2019;25(7):536–42.
Article
PubMed
Google Scholar
Sun B, Yuan J, Wang S, Lin J, Zhang W, Shao J, et al. Qingchang suppository ameliorates colonic vascular permeability in dextran-sulfate-sodium-induced colitis. Front Pharmacol. 2018;9:1235.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang X, Li D, Zhang Y, Wu S, Tang F. Costus root granules improve ulcerative colitis through regulation of TGF-beta mediation of the PI3K/AKT signaling pathway. Exp Ther Med. 2018;15(5):4477–84.
PubMed
PubMed Central
Google Scholar
Wu M, Shen A, Chen Y, Liu L, Li L, Sankararaman S, et al. Xinhuang tablets improve intestinal barrier function via regulating epithelial tight junctions in dextran sulfate sodium-induced ulcerative colitis mice. J Med Food. 2021;24(1):33–9.
Article
CAS
PubMed
Google Scholar
Ding Y, Chen M, Wang Q, Gao L, Feng Y, Wang S, et al. Integrating pharmacology and microbial network analysis with experimental validation to reveal the mechanism of composite sophora colon-soluble capsule against ulcerative colitis. Evid Based Complement Alternat Med. 2020;2020:9521073.
PubMed
PubMed Central
Google Scholar
Wang W, Xu C, Li X, Wang Z, Yang J, Shen Y, et al. Exploration of the potential mechanism of Banxia Xiexin decoction for the effects on TNBS-induced ulcerative colitis rats with the assistance of network pharmacology analysis. J Ethnopharmacol. 2021;277: 114197.
Article
CAS
PubMed
Google Scholar
Wei Y, Jiang N, Liu T, Liu C, Xiao W, Liang L, et al. The comparison of extraction methods of ganjiang decoction based on fingerprint, quantitative analysis and pharmacodynamics. Chin Med. 2020;15:81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Buchner AM, Schneider Y, Lichtenstein GR. Biosimilars in inflammatory bowel disease. Am J Gastroenterol. 2021;116(1):45–56.
Article
PubMed
Google Scholar
Zhu HH, Hu J, Lo-Coco F, Jin J. The simpler, the better: oral arsenic for acute promyelocytic leukemia. Blood. 2019;134(7):597–605.
Article
CAS
PubMed
Google Scholar