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Fig. 4 | Chinese Medicine

Fig. 4

From: Role of GRPR in Acupuncture Intervention in the “Itch-scratch Vicious Cycle” Spinal Circuit of Chronic Pruritus

Fig. 4

A Peripheral-Gastrin releasing peptide-Periaqueductal gray/Ventral tegmental area: Peripheral pruritic mediators activate GRPR + neurons in the superficial layer of the spinal dorsal horn by releasing GRP, nerve impulses uploaded to the VTA and PAG brain regions to feedback itching to the body cortex. B Acupuncture treatment of chronic pruritus and scratching cycle possible mechanism: Acupuncture treatment reducing the expression of GRPR in the spinal cord, desensitizing the itch-signaling pathways to VTA and PAG brain regions to relieve chronic itch

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Chinese Medicine

ISSN: 1749-8546

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