Berberine improves negative symptoms and cognitive function in patients with chronic schizophrenia via anti-inflammatory effect: a randomized clinical trial

Table 3 Correlations between the changes of inflammatory factors’ concentrations and those of clinical measures after treatment (month 3 minus baseline) in the experimental group

Out measures	IL-1β			IL-6			TNF-α
Out measures	r	t	P	r	t	P	r	t	P
Total score of SANS	0.210	2.112	0.039	0.078	1.578	0.120	0.023	1.168	0.248
Total score of five global rating items of SANS	0.041	0.303	0.763	0.033	0.245	0.807	0.004	0.026	0.979
Apathy of SANS	− 0.001	− 0.008	0.994	0.014	0.100	0.921	0.007	0.052	0.959
Poverty of thought of SANS	0.007	0.050	0.960	-0.002	-0.011	0.991	0.001	0.004	0.997
Abulia of SANS	− 0.008	− 0.056	0.956	− 0.007	− 0.045	0.964	− 0.009	− 0.067	0.947
Lack of interest and social interaction of SANS	− 0.001	− 0.005	0.996	− 0.005	− 0.040	0.968	− 0.002	− 0.013	0.990
Attention dysfunction of SANS	0.045	0.332	0.741	0.035	0.257	0.798	0.014	0.105	0.917
TMT-A	0.522	4.497	< 0.001	0.562	4.994	< 0.001	0.227	1.714	0.092
TMT-B	0.811	10.196	< 0.001	0.664	6.521	< 0.001	0.472	3.930	< 0.001
TMT-B minus TMT-A	0.289	2.220	0.031	0.102	0.751	0.456	0.244	1.852	0.069
HVLT	− 0.072	− 0.528	0.600	− 0.045	− 0.330	0.743	− 0.023	− 0.169	0.866

ISSN: 1749-8546