Berberine improves negative symptoms and cognitive function in patients with chronic schizophrenia via anti-inflammatory effect: a randomized clinical trial

Table 4 Analysis of factors related to the changes (month 3 minus baseline) of negative symptoms and cognitive function in the experimental group

Variables	Negative symptoms (R² = 0.267)			Attention and processing speed (R² = 0.442)			Executive function (R² = 0.681)
Variables	b	t	P	b	t	P	b	t	P
IL-1β, ng/l	0.112	2.157	0.036	0.567	4.562	< 0.001	0.983	11.815	< 0.001
IL-6, ng/l	0.034	1.452	0.153	0.593	5.282	< 0.001	0.720	6.646	< 0.001
TNF-α, ng/l	0.027	1.286	0.205	0.177	1.628	0.110	0.317	2.561	0.014

b indicates partial regression coefficient; R² indicates adjusted coefficient of determination; female was defined as the control in the variable of sex; negative symptoms was assessed by the total score of SANS; attention and processing speed was assessed by TMT-A; executive function was assessed by TMT-B

ISSN: 1749-8546