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Chinese Medicine

Open Access

Establishing an EU-China consortium on traditional Chinese medicine research

  • Halil Uzuner1Email author,
  • Tai-Ping Fan2,
  • Alberto Dias3,
  • De-an Guo4,
  • Hani S El-Nezami5 and
  • Qihe Xu1
Chinese Medicine20105:42

Received: 20 October 2010

Accepted: 14 December 2010

Published: 14 December 2010


Traditional Chinese medicine (TCM) is widely used in the European Union (EU) and attracts intense research interests from European scientists. As an emerging area in Europe, TCM research requires collaboration and coordination of actions. Good Practice in Traditional Chinese Medicine Research in the Post-genomic Era, also known as GP-TCM, is the first ever EU-funded 7th Framework Programme (FP7) coordination action, aiming to inform the best practice and harmonise research on the safety and efficacy of TCM through interdisciplinary exchange of experience and expertise among clinicians and scientists. With its increasingly large pool of expertise across 19 countries including 13 EU member states, Australia, Canada, China, Norway, Thailand and the USA, the consortium provides forums and collaboration platforms on quality control, extraction technology, component analysis, toxicology, pharmacology and regulatory issues of Chinese herbal medicine (CHM), as well as on acupuncture studies, with a particular emphasis on the application of a functional genomics approach. The project officially started in May 2009 and by the time of its conclusion in April 2012 a Europe-based academic society dedicated to TCM research will be founded to carry on the mission of GP-TCM.


Traditional Chinese medicine (TCM), especially Chinese herbal medicine (CHM) and acupuncture, is an ancient medical system used in China and other Asian countries for thousands of years [1, 2]. In contrast to the reductionist approach of Western medicine based on modern anatomy, physiology, pathology, pharmacology as well as cell and molecular biology, TCM uses a unique system and an individualised and holistic approach to describe health and disease, based on the philosophy of Yin-Yang balance and an emphasis on harmony of functions. These two medical systems differ greatly in many respects. In the past seven years, a number of international organisations were established in mainland China, Hong Kong and Macao, including the World Federation of Chinese Medicine Societies (WFCMS, September 2003), the Consortium for Globalisation of Chinese Medicine (CGCM, December 2003) and the International Society for Chinese Medicine (ISCM, 2004).

The Good Practice in Traditional Chinese Medicine Research in the Post-genomic Era (GP-TCM) consortium was launched by the European Commission on the 1st May 2009. This is a three-year coordination action project funded under the EU Seventh Framework Programme (FP7) with a total budget of €995,100. The central hypothesis of the consortium is that, using functional genomics technology, which allows high-content observations of whole profiles of molecules at different levels, eg DNA, mRNA, protein and metabolites, and furthermore linking them to clinically relevant biological functions, we might be in a better position than ever before to interpret and validate the scientific value of TCM in a holistic and function-oriented manner [311].


Focusing on research of CHM and acupuncture, we especially emphasise studies of CHMs, their complex chemical ingredients and their holistic impact on the functional genomics of patients. The overall aim of the consortium is to inform the best practice and harmonise research on the safety and efficacy of TCM using a functional genomics approach through exchange of opinions, experience and expertise among scientists in EU member states, China and other parts of the world. Specifically, we aim to undertake the following objectives:

  • Develop a European-Chinese network, collaborating on functional genomics research of TCM;

  • Review current practice of TCM research, identify problems and propose solutions;

  • Propose standard protocols of methodology;

  • Propose priority areas for future research;

  • Develop online resources to support and enhance pan-European studies of TCM research;

  • Facilitate and foster a sustainable European collaboration by founding a European society dedicated to TCM research.


As shown in Figure 1 through ten working groups known as work packages (WPs), the consortium takes actions to review the techniques, identify problems and solutions in the quality control (WP1), extraction and analysis (WP2) of CHMs. While these fundamental issues are addressed, discussion forums emphasising the use of functional genomics methodology in research of the safety, efficacy and mechanisms of CHMs (WP3-WP7) and acupuncture (WP8) form the core of this coordination project. The project covers toxicology (WP3), in vitro and in vivo pharmacology (WP4-WP5), clinical studies (WP6), as well as international regulatory issues of CHM (WP7). WP9 is dedicated to organising the Final Conference of the consortium at the end of the project and WP10 is charged to manage consortium-wide matters, such as appointment and coordination of WP leadership, recruitment of additional experts, editing website and newsletters, drafting standard operating procedures, providing scientific and technological support and guidance, organising internal review and quality assurance, as well as liaising with the Commission and other stakeholders and external authorities.
Figure 1

Structure of the GP-TCM Consortium. GP-TCM work package interaction and relationship: GP-TCM has ten interactive working groups, known as work packages (WP). WP1-WP7 specialises in quality control, component extraction and chemical analysis, toxicology, in vitro and in vivo pharmacology, clinical studies and regulatory issues in commercial R&D respectively. WP8 is specialised in acupuncture studies and WP9 is dedicated to organising the Final conference of the consortium, at which a new European society will be launched to succeed the mission of the consortium. WP10 is the managing, coordinating and leading body of the whole consortium, aiming at integrating the expertise and collating outputs of all WPs to achieve the overall objectives of the consortium.


As shown in Table 1 the consortium has 27 beneficiary (ie funded) partner organisations across ten EU member states (ie Austria, Belgium, Estonia, Germany, Ireland, Italy, the Netherlands, Portugal, Spain and the UK) and China, which is an International Cooperation Partner Country (ICPC) of the EU. The consortium has additional 60 non-beneficiary (ie unfunded) collaborating partner organisations as well as two independent experts from Australia, Austria, Belgium, China, Denmark, Finland, Germany, Italy, Luxembourg, the Netherlands, Norway, Thailand, the UK and the USA (Table 2). Please refer to the project website at for an updated list of consortium partners. This forms a diverse, multicultural and multidisciplinary team of about 150 principal investigators, including leading scientists, clinicians, TCM practitioners, as well as experts in industrial development and regulatory issues. Non-beneficiary membership is mainly based on consortium invitation and requires outstanding expertise needed for the project. Interested parties are welcome to contact us via the GP-TCM website GP-TCM currently covers half of the 27 EU member states and its members in China are largely in major eastern and southern cities. As an open-ended consortium, GP-TCM welcomes interested parties from all EU member states and China to join our network, sharing resources and forging collaborations. We will continue to develop and strengthen collaborations with friends in Africa, South America, Asia and non-EU European countries to exchange experience and lessons learnt in the research of traditional medicines.
Table 1

GP-TCM beneficiary members

GP-TCM beneficiary partners



King's College London


Dr. Qihe Xu

University of Vienna


Prof. Verena M. Dirsch

L'Université Libre de Bruxelles


Prof. Pierre Duez

Beijing University of Chinese Medicine


Prof Yanjiang Qiao

China Capital Medical University


Prof. Xiaomin Wang

Institute of Medicinal Plant Development


Prof. Xinmin Liu

Shanghai Institute of Acupuncture-Moxibustion


Prof. Huangan Wu

Shanghai University of Traditional Chinese Medicine


Dr. Liu Chenghai

University of Hong Kong


Dr. Hani El-Nezami

Asper Biotech Ltd


Ms. Janne Üksti

Federal Institute for Drugs and Medical Devices


Dr. Werner Knöss

University of Düsseldorf


Prof. Peter Proksch

University of Munich


Prof. Angelika Vollmar

University of Bonn


Prof. Gabriele König

Trinity College Dublin


Dr. Helen Sheridan

University of Milan


Prof. Enrica Bosisio

University of Padova


Prof. Maria Carrara

CMC Tasly Group BV

The Netherlands

Dr. You-Ping Zhu

Leiden University

The Netherlands

Prof. Robert Verpoorte

University of Minho


Prof. Alberto Dias

University of Alcala


Prof. F. Javier de Lucio Cazaña

University Hospital Ramón y Cajal-FIBIO


Dr. M. Laura García Bermejo

Acu-herb Consultant, Sheffield


Ms. Dan Jiang

University of Wolverhampton


Prof. Kelvin Chan

Royal Botanic Gardens, Kew


Prof. Monique Simmonds

University of Southampton


Prof. George Lewith

University of Cambridge


Dr. Tai-Ping Fan

Table 2

GP-TCM non-beneficiary members

GP-TCM Non-beneficiary partners



University of Western Sydney


Prof. Alan Bensoussan

University of Graz


Prof. Rudolf Bauer

University of Mons


Prof. Jean-Marie Colet

Beijing East Linden Science and Technology Co. Ltd.


Prof. Yanhuai Liu

China Academy of Chinese Medical Sciences


Prof. Aiping Lu

China-Japan Friendship Hospital


Prof. Ping Li

Dalian Institute of Chemical Physics


Prof. Xinmiao Liang

Hong Kong Baptist University


Prof. Zhongzhen Zhao

Hong Kong Buddhist Hospital


Prof. Vivian Wong

Jinan University


Prof. Xinsheng Yao

Peking University


Prof. Wenhan Lin



Mr. Abraham Chan

Shanghai Innovation Research Centre of Traditional Medicine


Prof. William Weiguo Jia

Shanghai Jiaotong University


Prof. Liping Zhao

Shanghai Institute of Materia Medica, Chinese Academy of Sciences


Prof. De-an Guo

Tongji University


Prof. Gang Pei

Tasly Institute of Tasly Group Co., Ltd.


Ms. Karolina J. Svedlund

Tianjin University of Traditional Chinese Medicine


Prof. Boli Zhang

University of Macau


Prof. Yi-Tao Wang

The Chinese University of Hong Kong


Prof. Ge Lin

Pfizer Corporation Hong Kong Ltd


Mr. Stephen Leung

State Food and Drug Administration


Prof. Zhong-zhi Qian

National Research Institute of Chinese Medicine, Taiwan


Prof. Yi-Tsau Huang

University of Aarhus


Prof. Brian Clark

University of Oulu


Prof. Olavi Pelkonen

Public Research Centre of Health


Dr. Ning Wang

Charité University Medical Center


Prof. Claudia M. Witt

Johannes Gutenberg University


Dr. Huige Li

University of Regensburg


Prof. Gerhard Franz

Philipps - Universität Marburg


Prof. Shuming Li

Max Planck Institute for Biophysics


Prof. Wolfgang Schwarz

Dr Willmar Schwabe GmbH & Co. KG


Dr. Günter Meng

Caesar & Loretz GmbH


Dr. Mirko Bayer

University of Cagliari


Prof. Enzo Tramontano

University of Rome Tor Vergata


Prof. Giovanna M. Franconi

Institute of Neurobiology and Molecular Medicine, Italian National Research Council


Dr. Luigi Manni

SU BioMedicine

The Netherlands

Prof. Jan van der Greef

Norwegian University of Science and Technology


Prof. Odd Georg Nilsen

Thailand Ministry of Public Health


Dr. Prat Boonyawongviroj

School of Pharmacy


Prof. Michael Heinrich

Brunel University


Prof. Ian A. Sutherland

University of Reading


Prof. Elizabeth Williamson

Guy's & St Thomas' NHS Foundation Trust


Prof. Debbie Shaw

University of Nottingham


Prof. Sue Watson

University of Warwick


Prof. Kenneth Muir

University of Westminster


Dr. Volker Scheid

University of Lincoln


Dr. Huijun Shen

Thames Valley University


Prof. Nicola Robinson

University of the West England


Prof. Quan Min Zhu

Imperial College London


Dr. Daqing Ma

Global Regulatory Services


Mrs. Greer Deal

Link China Pharma Solutions


Mr. Marshall Ma

University of Oxford


Ms. Rebecca Richmond

University of East London


Dr. Tianjun Wang

Pharsafer Associates Limited


Dr. Graeme Ladds



Mr. Mazin Al-Khafaji

University of Louisville


Prof. Y. James Kang

Yale University


Prof. Yung-Chi Cheng

U.S. Food and Drug Administration


Dr. Shaw T. Chen

Vanderbilt University Medical Center


Dr. Lijun Ma



Dr. Shouming Zhong



Dr. Daryl Rees

Progress and difficulties

During the first 18 months of the project (May 2009-October 2010), the management team (WP10) has coordinated a highly successful team build-up and re-construction. With the ever-strengthening expertise pool, WP10 has developed a number of committees and panels that lead the consortium with clear divisions of labour. WP10 has led the design and updates of the professional GP-TCM website and all WPs have established their homepages and online discussion facilities. Periodic newsletters have enabled members to share information and stay as a united team. Significantly, a series of face-to-face meetings, including consortium and WP kick-off meetings and the 1st Annual General Meeting, have been organised to monitor the consortium, promote interactions and collaborations and ensure milestones are met and deliverables accomplished on time and in high quality.

Noteworthy WP-specific achievements are as follows. WP1 led the creation of a list of nearly 300 species of plants and fungi commonly used in TCM in Europe and China and a priority list of 11 species will be used by all WPs in their initial literature analysis. WP2 worked jointly with WP1, linking quality control, extraction technology and chemical analysis, with special emphasis on the important role of paozhi (processing) in the production of CHM. WP3 produced a list of toxic plants for further literature study and identified 3 major fields of action: (i) investigation of methods (classical and functional genomics) applicable to toxicity evaluation; (ii) study of toxicological reports available on a series of CHM; (iii) review of pharmacovigilance safety data. WP4 established evaluation criteria for scoring scientific articles and began the creation of an appropriate database of literature encompassing functional genomic applications in CHM research. WP5 performed reviews on CHM literature involving animal models, especially models of cancer and its conclusions have laid a solid foundation for further literature analysis on application of functional genomics in CHM research and proposing good practice in animal studies of CHM. WP6 gathered literature on seminal studies in clinical CHM studies and drafted a guideline on clinical trials of CHM. WP6 and WP8 collaboratively designed an online survey targeting TCM practitioners and the survey is currently undergoing in collaboration with 30 professional acupuncture and TCM organisations. WP7 brought together wide-ranging experiences and expertise in drug development and registration from Europe, China, Australia and North America to discuss the legislative and regulatory issues relevant to CHM. Together they are developing a comprehensive document providing comparisons of different practices on CHM regulations and this will be extremely helpful for the EU to develop its future policies and for companies to develop products for the global market. WP9 discussed the time and format of the Final Conference and preliminary bookings of venue has been made.

The major difficulty encountered by the consortium is unsurprisingly the language barrier. There is a lack of accessibility to original Chinese publications in Europe, and even if they are available, fast and accurate translation of these materials is impossible, preventing the consortium from extensively studying classic Chinese medical literature and evaluating a great deal of modern Chinese medical literature. While we strongly encourage our members to master both English and Chinese languages, we welcome members from various linguistic, ethnic and cultural backgrounds to work in close collaboration.

Further work

As the first ever EU-China collaborative consortium dedicated to TCM research, we will continue to promote EU-China dialogues and collaborations in this important emerging supra-disciplinary area. As a network of principal investigators, we will collaborate to train the next generation of scientists who are more comprehensively equipped to study complex drugs such as CHM and personalised medicine such as TCM. As a coordination action involving much literature review and evaluation, we acknowledge the huge importance of good practice in scientific publication and will continue to support open-access publications.

Concluding remarks

As an EU-China collaboration dedicated to TCM research, we are keen to incorporate ourselves into the worldwide landscape of TCM research community and serve as a constructive member. We sincerely support the international TCM community to bundle forces to improve TCM research funding from both the public and private sectors and to help shape the medicine of tomorrow together.



Consortium for Globalisation of Chinese Medicine


Chinese herbal medicines


European Union


Seventh Framework Programme


Good Practice in Traditional Chinese Medicine Research in the Post-genomic Era


International Cooperation Partner Country


International Society for Chinese Medicine


Traditional Chinese medicine


World Federation of Chinese Medicine Societies


work packages.



This work has received funding from the European Union's Framework Programme 7 [FP7/2007-2013] under the grant agreement No 223154. The consortium thanks the European Commission for the grant, and the Chinese government, Innovation China UK and many other advisory bodies for their generous support.

Authors’ Affiliations

Department of Renal Medicine, King's College London, London, UK
Department of Pharmacology, University of Cambridge, Cambridge, UK
CITAB-UM, Department of Biology, University of Minho, Braga, Portugal
Shanghai Research Centre for TCM Modernization, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
School of Biological Sciences, University of Hong Kong, Hong Kong, China


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