Cyclocarya paliurus (Batal.) Ijinskaja (CP) is a monotypic genus plant, also called sweet tea tree that belongs to the Juglandaceae family, which is mainly distributed in the subtropical highlands in China. Our p...
Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on human hepatocellular carci...
Authors: Yi Luo, Yu Feng, Lei Song, Gan-Qing He, Sha Li, Sha-Sha Bai, Yu-Jie Huang, Si-Ying Li, Mohammed M. Almutairi, Hong-Lian Shi, Qi Wang and Ming Hong
Leflunomide (LEF) is a first-line disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA). However, there are still a few nonresponders. It is logical to suggest that employing combinations ...
Authors: Chi Zhang, Daogang Guan, Miao Jiang, Chao Liang, Li Li, Ning Zhao, Qinglin Zha, Wandong Zhang, Cheng Lu, Ge Zhang, Jian Liu and Aiping Lu
Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, the dried root and rhizome or stem of Acanthopanax senticosus, is commonly known as Siberian ginseng or Ciwujia in Chinese. It is used all over the world as a...
Authors: Kit-Man Lau, Grace Gar-Lee Yue, Yuk-Yu Chan, Hin-Fai Kwok, Si Gao, Chun-Wai Wong and Clara Bik-San Lau
Depression is the most disastrous mood disorder affecting the health of individuals. Conventional treatments with chemical compounds for depression have limitations, while herbal medicine has unique therapeuti...
Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease that comprises ulcerative colitis (UC) and Crohn’s disease (CD). IBD involves the ileum, rectum, and colon, and common clinical...
Authors: Caifang Gao, Lijuan Liu, Yangyang Zhou, Zhaoxiang Bian, Shengpeng Wang and Yitao Wang
Sanguisorba officinalis, a popular Chinese herb, called DiYu, has been shown to inhibit the growth of many human cancer cell lines, including colorectal cancer cells. The aims of this study were to discover the a...
Authors: Wa Li, Chun-juan Yang, Li-qian Wang, Juan Wu, Cong Dai, Yue-mei Yuan, George Q. Li and Mei-cun Yao
Pseudostellaria heterophylla is one of the well-known traditional Chinese medicines and has been used in clinics for 100 years in China. The chemistry and pharmacology of P. heterophylla were reviewed to understa...
Authors: De-jun Hu, Farid Shakerian, Jing Zhao and Shao-Ping Li
Panax ginseng is widely used as functional food and traditional Chinese medicine. To satisfy the market supply and medication safety, biofertilizers are used as agents to stimulate the growth and production of P....
Authors: Linlin Dong, Yong Li, Jiang Xu, Juan Yang, Guangfei Wei, Liang Shen, Wanlong Ding and Shilin Chen
Alzheimer’s disease (AD) is a common human neurodegenerative disease, which is characterized by the progressive loss of memory and the cognitive impairment. Since the etiology of AD is still unknown, it is ext...
Authors: Cheong-Meng Chong, Huanxing Su, Jin-Jian Lu and Yitao Wang
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, which is commonly treated with antidiarrhoeal, antispasmodics, serotonergic agents or laxative agents. These treatments provide ...
Cyathulae Radix (CR), also known as “Chuanniux” is a well-known traditional Chinese herbal medicine that has been used in China for thousands of years. The present work reviewed advances in traditional uses, o...
Authors: Yongliang Huang, Shanshan Wang, Li Liu, Wei Peng, Jiaolong Wang, Ying Song, Qianghua Yuan, Xing Yuan and Chunjie Wu
This study aims to assess clinical characteristics in FD with spleen deficiency syndrome and metabolic perturbations involved in FD progress. We combined metabolic biomarkers and clinical features into a bette...
Authors: Jiaqi Zhang, Xue Wang, Xiaoshuang Shi, Jingyi Xie, Min Zhang, Jinxin Ma, Fengyun Wang and Xudong Tang
Major depressive disorder (MDD) is highly heterogeneous in pathogenesis and manifestations. Further classification may help characterize its heterogeneity. We previously have shown differential metabolomic pro...
Authors: Lan-Ying Liu, Xiao-Pei Xu, Li-Yuan Luo, Chun-Qing Zhu, Ya-Ping Li, Pei-Rong Wang, Yuan-Yuan Zhang, Chun-Yu Yang, Hong-Tao Hou, Yu-Lin Cao, Gang Wang, Edward S. Hui and Zhang-Jin Zhang
The simple and caged xanthones from Clusiaceae showed significant antineoplastic activity. This study aims to identify structural diverse xanthones and search for novel antitumor natural products from this fam...
Authors: Cuicui Jia, Chi Gong, Hong Chen, Jing Pu, Dahong Li, Zhanlin Li and Huiming Hua
The discovery of bioactive compounds in traditional Chinese medicine (TCM) has become an important field in TCM modernization. Ligand fishing is a suitable method for discovery of bioactive compounds in comple...
Authors: Shangxin Guo, Xiaotong Lin, Yi Wang and Xingchu Gong
Water extract (WAE) and ultrafine powder (UFP) are two types of commonly used supplements in preparing various pharmaceutical products and functional foods. However, the correlations of the chemical compositio...
Authors: Zhi Xin Li, Guan Ding Zhao, Wei Xiong, Ke Gang Linghu, Qiu Shuo Ma, Wai San Cheang, Hua Yu and Yitao Wang
Biofilm is a natural form of bacterial growth ubiquitously in environmental niches. The biofilm formation results in increased resistance to negative environmental influences including resistance to antibiotic...
Authors: Lan Lu, Wei Hu, Zeru Tian, Dandan Yuan, Guojuan Yi, Yangyang Zhou, Qiang Cheng, Jie Zhu and Mingxing Li
Homeostasis is a crucial concept used to describe the condition of patients and the roles of herbs in traditional Chinese medicine. Qi-deficiency pattern is one of the conditions when loss of homeostasis and i...
Authors: Pin-Hao Ko, Chiung-Wei Huang, Hen-Hong Chang, Eric Y. Chuang, Mong-Hsun Tsai and Liang-Chuan Lai
Dryopteris crassirhizoma Nakai and Osmunda japonica Thunb. are ferns that are popularly used for medicine, as recorded by the Chinese pharmacopoeia, and are distributed in different regions of China. However, O. ...
Authors: Liang Xu, Yanping Xing, Bing Wang, Chunsheng Liu, Wenquan Wang and Tingguo Kang
Nowadays, traditional Chinese medicines (TCMs) have been reported to provide reliable therapies for viral pneumonia, but the therapeutic mechanism remains unknown. As a systemic approach, metabolomics provides...
Authors: Lili Lin, Hua Yan, Jiabin Chen, Huihui Xie, Linxiu Peng, Tong Xie, Xia Zhao, Shouchuan Wang and Jinjun Shan
Shikonin (SKN), a naphthoquinone compound, is isolated from Chinese herbal medicine Lithospermum root and has been studied as an anticancer drug candidate in human tumor models. This study is designed to investig...
Authors: Zhu Wang, Jianhua Yin, Mingxing Li, Jing Shen, Zhangang Xiao, Yueshui Zhao, Chengliang Huang, Hanyu Zhang, Zhuo Zhang, Chi Hin Cho and Xu Wu
Fuzi-Lizhong pill (FZLZP), which was first recorded in the Classic–“Taiping Huimin Heji Ju Fang” of the Song Dynasty, has been widely used to treat gastrointestinal disease in clinic for thousands of years in ...
Authors: Zhen Zhang, Maoyuan Jiang, Xinyi Wei, Jinfeng Shi, Zhao Geng, Shasha Yang, Chaomei Fu and Li Guo
Traditional Chinese medicine (TCM) represents the crystallization of Chinese wisdom and civilization. It has been valued as the renewable source for the discovery of novel drugs, owing to its long-term proved ...
Authors: Jing Wang, Ming-Yue Wu, Jie-Qiong Tan, Min Li and Jia-Hong Lu
The endangered rate of medicinal plant exceeds that of endangered plant species. However, blindly introducing medicinal plants in regions without comprehensively considering the involved environmental factors ...
Authors: Jie Wu, Xiwen Li, Linfang Huang, Xiangxiao Meng, Haoyu Hu, Lu Luo and Shilin Chen
Baduanjin, a traditional Chinese exercise therapy, has been widely used in China to treat type 2 diabetes (T2DM) with depression (DD). However, the underlying mechanism of Baduanjin in anti-DD is unclear. This...
Authors: Tian An, Zhong-Chen He, Xin-Qing Zhang, Jun Li, Ai-Ling Chen, Fang Tan, Hong-Dong Chen, Bo-Han Lv, Juan Lian, Si-Hua Gao and Guang-Jian Jiang
The combination of Radix Paeoniae Alba (RPA) and Rhizoma Atractylodis Macrocephalae (RAM) has long been used as a classic herb pair for the treatment of gynecologic and gastrointestinal diseases, but the under...
Authors: Yangyang Zhou, Hongxun Tao, Anqi Wang, Zhangfeng Zhong, Xu Wu, Mei Wang, Zhaoxiang Bian, Shengpeng Wang and Yitao Wang
Differential proteomics, which has been widely used in studying of traditional Chinese medicines (TCMs) during the past 10 years, is a powerful tool to visualize differentially expressed proteins and analyzes ...
Authors: Yi-Yao Yang, Feng-Qing Yang and Jian-Li Gao
Systems biology is an academic field that attempts to integrate different levels of information to understand how biological systems function. It is the study of the composition of all components of a biologic...
Authors: Fei-Fei Cai, Wen-Jun Zhou, Rong Wu and Shi-Bing Su
The incidence and mortality of cancer metastasis is high worldwide. Despite of the chemotherapeutic agents, many cancer patients still take traditional Chinese herbal prescriptions as adjuvant treatments. Howe...
Authors: Grace Gar-Lee Yue, Julia Kin-Ming Lee, Ben Chung-Lap Chan, Hin-Fai Kwok, Sandy Wan-Heng Hoi, Daniel Man-Yuen Sze, Kwok-Pui Fung, Ping-Chung Leung and Clara Bik-San Lau
The pathogenesis of irritable bowel syndrome (IBS) is closely related to intestinal dysbacteriosis and can be controlled by moxibustion treatment. However, the mechanism underlying the therapeutic value of mox...
Authors: Xiaomei Wang, Qin Qi, Yuanyuan Wang, Huangan Wu, Xiaoming Jin, Huan Yao, Duiyin Jin, Yanan Liu and Cun Wang
Aconiti Lateralis Radix Praeparata has been used as the first cardiac drug over a 1000 years in Asian countries. Although most detoxification products are confirmed to be safe, the effect is not potent as desired...
Authors: Ya-nan He, Ding-kun Zhang, Jun-zhi Lin, Xue Han, Ya-ming Zhang, Hai-zhu Zhang, Jin Pei, Ming Yang and Jia-bo Wang
Fukeqianjin formula has been effectively used in the treatment of pelvic inflammatory disease (PID) and the related complications in clinic. Although there have been some studies about the underlying mechanism...
Authors: Yan Zhang, Wei Li, Liang Zou, Yun Gong, Peng Zhang, Shasha Xing and Hang Yang
Traditional Chinese medicines (TCM) have a long history of use because of its potential complementary therapy and fewer adverse effects. However, the toxicity and safety issues of TCM have drawn considerable a...
Authors: Li Duan, Long Guo, Lei Wang, Qiang Yin, Chen-Meng Zhang, Yu-Guang Zheng and E.-Hu Liu
Atractylodes lancea Thunb. DC. (AL) has a long history as one of the important herbs used in East Asia. This review is on the purpose of providing a comprehensive summary of the pharmacological effects of AL and ...
Diosgenin, mainly extracted from wild diosgenin-contained Dioscorea species, is a well-known starting material of steroidal and contraceptive drugs. However, due to large market demand and increasingly ecological...
Authors: Liang Shen, Jiang Xu, Lu Luo, Haoyu Hu, Xiangxiao Meng, Xiwen Li and Shilin Chen
Modern studies have shown that adaptogens can non-specifically enhance the resistance of human body under a wide range of external stress conditions with a multi-targeted and multi-channel network-like manner,...
Authors: Lian-ying Liao, Yi-fan He, Li Li, Hong Meng, Yin-mao Dong, Fan Yi and Pei-gen Xiao
Microbial fermentation has been widely applied in traditional Chinese medicine (TCM) for thousands of years in China. Various beneficial effects of fermentation for applications in TCM or herbals have been rep...
Authors: Yan Yan, Chenhui Du, Zhenyu Li, Min Zhang, Jin Li, Jinping Jia, Aiping Li, Xuemei Qin and Qiang Song
Major depressive disorder (MDD) is a highly heterogeneous disease. Further classification may characterize its heterogeneity. The purpose of this study was to examine whether metabolomic variables could differ...
Plants are providing reliable therapy since time immemorial. Pakistan has a great diversity in medicinal flora and people use these ethno-medicines to deal with many skin problems. This review explores the fun...
Authors: Alamgeer, Amber Sharif, Hira Asif, Waqas Younis, Humayun Riaz, Ishfaq Ali Bukhari and Asaad Mohamed Assiri
Compounds with the ability to scavenge reactive oxygen species (ROS) and inhibit tyrosinase may be useful for the treatment and prevention from ROS-related diseases. The number and location of phenolic hydroxy...
Authors: Ai-Ren Zuo, Huan-Huan Dong, Yan-Ying Yu, Qing-Long Shu, Li-Xiang Zheng, Xiong-Ying Yu and Shu-Wen Cao
Internationalization of Traditional/Complementary Medicine (T&CM) products is important for initiating and sustaining developments in this field. Particularly for traditional Chinese medicines (TCMs), the glob...
Authors: Jiatong Li, Jianfan Zhu, Hao Hu, Joanna E. Harnett, Chi Ieong Lei, Ka Yin Chau, Ging Chan and Carolina Oi Lam Ung
San-ao decoction (SAD) has been widely used in Chinese medicine against respiratory diseases, such as asthma and rhinallergosis. The bioactive compounds for such pharmacological action remain unknown.
Authors: Fuhuan Fei, Huanmei Sun, Xixi Cheng, Jiajun Liu, Jing Wang, Qian Li and Yajun Zhang
Respiratory disorders are a common cause of malady and demise in Pakistan due to its remoteness, cold and harsh climatic conditions as well as scarce health care facilities. The people rely upon the indigenous...
Authors: Alamgeer, Waqas Younis, Hira Asif, Amber Sharif, Humayun Riaz, Ishfaq Ali Bukhari and Asaad Mohamed Assiri
Polysaccharides are carbohydrate chains composed of linked monosaccharide units. Accumulating studies report that polysaccharides isolated from Dendrobium officinale have a variety of functions. However, the comp...
Authors: Yuan Wei, Linwei Wang, Dujun Wang, Dan Wang, Chongwei Wen, Bangxin Han and Zhen Ouyang
Polycystic ovary syndrome (PCOS) significantly affects women’s health and well-being. To explore the pharmacological basis of the Erxian decoction (EXD) action in PCOS therapy, a network interaction analysis w...
Authors: Lihong Liu, Bo Du, Haiying Zhang, Xiaofei Guo, Zheng Zhou, Aihui Xiu, Chang Liu, Shiyu Su and Hao Ai
Bushen Huoxue decoction (BHD) has a significant effect on fracture rehabilitation, yet its underlying
mechanism is still unknown. The purpose of this study was to explore whether BHD promotes bone marrow mese...
Authors: Wei Shen, Hui Luo, Liangliang Xu, Zhifang Wu, Hongtai Chen, Yamei Liu, Lijuan Yu, Liuchao Hu, Bin Wang and Yiwen Luo
Chemotherapy is a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur with chemotherapy in clinic, resulting in poor prognosis and recurrence. Nowadays, Chinese...
Authors: Zhangfeng Zhong, Haibing Yu, Shengpeng Wang, Yitao Wang and Liao Cui
