Taylor M. Complementary and alternative approaches to menopause. Endocrinol Metab Clin North Am. 2015;44(3):619–48.
Article
PubMed
Google Scholar
Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and their bioactive phytochemicals for women’s health. Pharmacol Rev. 2016;68(4):1026–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Cirillo C, Capasso R. Constipation and botanical medicines: an overview. Phytother Res PTR. 2015;29(10):1488–93.
Article
PubMed
Google Scholar
Neyrinck AM, Etxeberria U, Taminiau B, Daube G, Van Hul M, Everard A, et al. Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota. Mol Nutr Food Res. 2017;61(1):1500899.
Article
CAS
Google Scholar
Lin TJ, Lin CF, Chiu CH, Lee MC, Horng JT. Inhibition of endosomal fusion activity of influenza virus by Rheum tanguticum (da-huang). Sci Rep. 2016;6:27768.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yan J, Xie G, Liang C, Hu Y, Zhao A, Huang F, et al. Herbal medicine Yinchenhaotang protects against alpha-naphthylisothiocyanate-induced cholestasis in rats. Sci Rep. 2017;7(1):4211.
Article
PubMed
PubMed Central
CAS
Google Scholar
Hu X, Liu S, Zhu J, Ni H. Dachengqi decoction alleviates acute lung injury and inhibits inflammatory cytokines production through TLR4/NF-kappaB signaling pathway in vivo and in vitro. J Cell Biochem. 2019;120(6):8956–64.
Article
CAS
PubMed
Google Scholar
Gong Z, Lin J, Zheng J, Wei L, Liu L, Peng Y, et al. Dahuang Zhechong pill attenuates CCl4-induced rat liver fibrosis via the PI3K-Akt signaling pathway. J Cell Biochem. 2020;121(2):1431–40.
Article
CAS
PubMed
Google Scholar
Huang Q, Lu G, Shen HM, Chung MC, Ong CN. Anti-cancer properties of anthraquinones from rhubarb. Med Res Rev. 2007;27(5):609–30.
Article
CAS
PubMed
Google Scholar
Sun J, Wu Y, Dong S, Li X, Gao W. Influence of the drying method on the bioactive compounds and pharmacological activities of rhubarb. J Sci Food Agric. 2018;98(9):3551–62.
Article
CAS
PubMed
Google Scholar
Li L, Song X, Yin Z, Jia R, Li Z, Zhou X, et al. The antibacterial activity and action mechanism of emodin from Polygonum cuspidatum against Haemophilus parasuis in vitro. Microbiol Res. 2016;186–187:139–45.
Article
PubMed
CAS
Google Scholar
Ahn SM, Kim HN, Kim YR, Choi YW, Kim CM, Shin HK, et al. Emodin from Polygonum multiflorum ameliorates oxidative toxicity in HT22 cells and deficits in photothrombotic ischemia. J Ethnopharmacol. 2016;188:13–20.
Article
CAS
PubMed
Google Scholar
Yang J, Zhu A, Xiao S, Zhang T, Wang L, Wang Q, et al. Anthraquinones in the aqueous extract of Cassiae semen cause liver injury in rats through lipid metabolism disorder. Phytomedicine. 2019;64:153059.
Article
CAS
PubMed
Google Scholar
Moreira TF, Sorbo JM, Souza FO, Fernandes BC, Ocampos FMM, de Oliveira DMS, et al. Emodin, physcion, and crude extract of Rhamnus sphaerosperma var. pubescens induce mixed cell death, increase in oxidative stress, DNA damage, and inhibition of AKT in cervical and oral squamous carcinoma cell lines. Oxid Med Cell Longev. 2018;2018:2390234.
Article
PubMed
PubMed Central
CAS
Google Scholar
Dong X, Fu J, Yin X, Cao S, Li X, Lin L, et al. Emodin: a review of its pharmacology, toxicity and pharmacokinetics. Phytotherapy research : PTR. 2016;30(8):1207–18.
Article
CAS
PubMed
Google Scholar
Song YD, Li XZ, Wu YX, Shen Y, Liu FF, Gao PP, et al. Emodin alleviates alternatively activated macrophage and asthmatic airway inflammation in a murine asthma model. Acta Pharmacol Sin. 2018;39(8):1317–25.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ding Y, Xu J, Cheng LB, Huang YQ, Wang YQ, Li H, et al. Effect of emodin on coxsackievirus B3m mediated-encephalitis in hand, foot and mouth disease by inhibiting toll-like receptor 3 pathway in vitro and in vivo. J Infect Dis. 2020;222(3):443–55.
Article
CAS
PubMed
Google Scholar
Wu CC, Chen MS, Cheng YJ, Ko YC, Lin SF, Chiu IM, et al. Emodin inhibits EBV reactivation and represses NPC tumorigenesis. Cancers. 2019;11(11):1795.
Article
CAS
PubMed Central
Google Scholar
Chang KC, Li L, Sanborn TM, Shieh B, Lenhart P, Ammar D, et al. Characterization of emodin as a therapeutic agent for diabetic cataract. J Nat Prod. 2016;79(5):1439–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lin L, Liu Y, Fu S, Qu C, Li H, Ni J. Inhibition of mitochondrial complex function-the hepatotoxicity mechanism of emodin based on quantitative proteomic analyses. Cells. 2019;8(3):263.
Article
CAS
PubMed Central
Google Scholar
Wang C, Dai X, Liu H, Yi H, Zhou D, Liu C, et al. Involvement of PPARγ in emodin-induced HK-2 cell apoptosis. Toxicol In Vitro. 2015;29(1):228–33.
Article
CAS
PubMed
Google Scholar
Rossi M, Wen K, Caruso F, Belli S. Emodin scavenging of superoxide radical includes π-π Interaction. X-ray crystal structure, hydrodynamic voltammetry and theoretical studies. Antioxidants. 2020;9(3):194.
Article
CAS
PubMed Central
Google Scholar
Hoesel B, Schmid JA. The complexity of NF-kappaB signaling in inflammation and cancer. Mol Cancer. 2013;12:86.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xu K, Zhou T, Huang Y, Chi Q, Shi J, Zhu P, et al. Anthraquinone emodin inhibits tumor necrosis factor alpha-induced calcification of human aortic valve interstitial cells via the NF-κB pathway. Front Pharmacol. 2018;9:1328.
Article
CAS
PubMed
PubMed Central
Google Scholar
Luo S, Deng X, Liu Q, Pan Z, Zhao Z, Zhou L, et al. Emodin ameliorates ulcerative colitis by the flagellin-TLR5 dependent pathway in mice. Int Immunopharmacol. 2018;59:269–75.
Article
CAS
PubMed
Google Scholar
Ding Y, Liu P, Chen ZL, Zhang SJ, Wang YQ, Cai X, et al. Emodin attenuates lipopolysaccharide-induced acute liver injury via inhibiting the TLR4 signaling pathway in vitro and in vivo. Front Pharmacol. 2018;9:962.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhu T, Zhang W, Feng SJ, Yu HP. Emodin suppresses LPS-induced inflammation in RAW264.7 cells through a PPARgamma-dependent pathway. Int Immunopharmacol. 2016;34:16–24.
Article
PubMed
CAS
Google Scholar
Zhang W, Lu X, Wang W, Ding Z, Fu Y, Zhou X, et al. Inhibitory effects of emodin, thymol, and astragalin on leptospira interrogans-induced inflammatory response in the uterine and endometrium epithelial cells of mice. Inflammation. 2017;40(2):666–75.
Article
CAS
PubMed
Google Scholar
Ka SO, Hwang HP, Jang JH, Hyuk Bang I, Bae UJ, Yu HC, et al. The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury. Sci Rep. 2015;5:14816.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marques-Rocha JL, Samblas M, Milagro FI, Bressan J, Martínez JA, Marti A. Noncoding RNAs, cytokines, and inflammation-related diseases. FASEB J. 2015;29(9):3595–611.
Article
CAS
PubMed
Google Scholar
Ou C, Li G. Long non-coding RNA TUG1: a novel therapeutic target in small cell lung cancer. J Thorac Dis. 2017;9(7):E644–5.
Article
PubMed
PubMed Central
Google Scholar
Katsushima K, Natsume A, Ohka F, Shinjo K, Hatanaka A, Ichimura N, et al. Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment. Nat Commun. 2016;7:13616.
Article
PubMed
PubMed Central
Google Scholar
Liang Z, Ren C. Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells. Biomed Pharmacother. 2018;103:897–902.
Article
CAS
PubMed
Google Scholar
Zang L, Song Y, Yu F, Liu X. Emodin relieved lipopolysaccharide-evoked inflammatory damage in WI-38 cells by up-regulating taurine up-regulated gene 1. BioFactors. 2020;46(5):860–8.
Article
CAS
PubMed
Google Scholar
Iorio MV, Croce CM. MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol. 2009;27(34):5848–56.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dong H, Lei J, Ding L, Wen Y, Ju H, Zhang X. MicroRNA: function, detection, and bioanalysis. Chem Rev. 2013;113(8):6207–33.
Article
CAS
PubMed
Google Scholar
Shiga A, Nozaki H, Yokoseki A, Nihonmatsu M, Kawata H, Kato T, et al. Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-beta1 via cleavage of proTGF-beta1. Hum Mol Genet. 2011;20(9):1800–10.
Article
CAS
PubMed
Google Scholar
Xiang H, Tao X, Xia S, Qu J, Song H, Liu J, et al. Emodin Alleviates sodium taurocholate-induced pancreatic acinar cell injury via microRNA-30a-5p-mediated inhibition of high-temperature requirement A/transforming growth factor beta 1 inflammatory signaling. Front Immunol. 2017;8:1488.
Article
PubMed
PubMed Central
CAS
Google Scholar
Xie R, Liu M, Li S. Emodin weakens liver inflammatory injury triggered by lipopolysaccharide through elevating microRNA-145 in vitro and in vivo. Artif Cells Nanomed Biotechnol. 2019;47(1):1877–87.
Article
CAS
PubMed
Google Scholar
Jeffries J, Zhou W, Hsu AY, Deng Q. miRNA-223 at the crossroads of inflammation and cancer. Cancer Lett. 2019;451:136–41.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang Y, Jiang Z, Zhuge D. Emodin attenuates lipopolysaccharide-induced injury via down-regulation of miR-223 in H9c2 cells. Int Heart J. 2019;60(2):436–43.
Article
CAS
PubMed
Google Scholar
Song Y, Cui X, Zhao R, Hu L, Li Y, Liu C. Emodin protects against lipopolysaccharide-induced inflammatory injury in HaCaT cells through upregulation of miR-21. Artif Cells Nanomed Biotechnol. 2019;47(1):2654–61.
Article
CAS
PubMed
Google Scholar
Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140(6):821–32.
Article
CAS
PubMed
Google Scholar
Han JW, Shim DW, Shin WY, Heo KH, Kwak SB, Sim EJ, et al. Anti-inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation. Int J Mol Sci. 2015;16(4):8102–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Giuliani AL, Sarti AC, Falzoni S, Di Virgilio F. The P2X7 receptor-interleukin-1 liaison. Front Pharmacol. 2017;8:123.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhang Q, Tao X, Xia S, Qu J, Song H, Liu J, et al. Emodin attenuated severe acute pancreatitis via the P2X ligandgated ion channel 7/NODlike receptor protein 3 signaling pathway. Oncol Rep. 2019;41(1):270–8.
CAS
PubMed
Google Scholar
Zhang Q, Hu F, Guo F, Zhou Q, Xiang H, Shang D. Emodin attenuates adenosine triphosphate-induced pancreatic ductal cell injury in vitro via the inhibition of the P2X7/NLRP3 signaling pathway. Oncol Rep. 2019;42(4):1589–97.
CAS
PubMed
Google Scholar
Gao Z, Sui J, Fan R, Qu W, Dong X, Sun D. Emodin protects against acute pancreatitis-associated lung injury by inhibiting NLPR3 inflammasome activation via Nrf2/HO-1 signaling. Drug Des Dev Ther. 2020;14:1971–82.
Article
CAS
Google Scholar
Xu Q, Wang M, Guo H, Liu H, Zhang G, Xu C, et al. Emodin alleviates severe acute pancreatitis-associated acute lung injury by inhibiting the cold-inducible RNA-binding protein (CIRP)-mediated activation of the NLRP3/IL-1β/CXCL1 signaling. Front Pharmacol. 2021;12:655372.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ye B, Chen X, Dai S, Han J, Liang X, Lin S, et al. Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes. Drug Des Dev Ther. 2019;13:975–90.
Article
CAS
Google Scholar
Chen YK, Xu YK, Zhang H, Yin JT, Fan X, Liu DD, et al. Emodin alleviates jejunum injury in rats with sepsis by inhibiting inflammation response. Biomed Pharmacother. 2016;84:1001–7.
Article
CAS
PubMed
Google Scholar
Medford AR, Millar AB. Vascular endothelial growth factor (VEGF) in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): paradox or paradigm? Thorax. 2006;61(7):621–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev. 2004;56(4):549–80.
Article
CAS
PubMed
Google Scholar
Li X, Shan C, Wu Z, Yu H, Yang A, Tan B. Emodin alleviated pulmonary inflammation in rats with LPS-induced acute lung injury through inhibiting the mTOR/HIF-1alpha/VEGF signaling pathway. Inflamm Res. 2020;69(4):365–73.
Article
CAS
PubMed
Google Scholar
Wamil M, Battle JH, Turban S, Kipari T, Seguret D, de Sousa PR, et al. Novel fat depot-specific mechanisms underlie resistance to visceral obesity and inflammation in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes. 2011;60(4):1158–67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Esteves CL, Kelly V, Breton A, Taylor AI, West CC, Donadeu FX, et al. Proinflammatory cytokine induction of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in human adipocytes is mediated by MEK, C/EBPbeta, and NF-kappaB/RelA. J Clin Endocrinol Metab. 2014;99(1):E160-168.
Article
PubMed
Google Scholar
Lai W, Tian X, Xiang Q, Chu K, Wei Y, Deng J, et al. 11beta-HSD1 modulates LPS-induced innate immune responses in adipocytes by altering expression of PTEN. Mol Endocrinol. 2015;29(4):558–70.
Article
CAS
PubMed
PubMed Central
Google Scholar
Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011;11(11):723–37.
Article
CAS
PubMed
PubMed Central
Google Scholar
Iwanowycz S, Wang J, Altomare D, Hui Y, Fan D. Emodin bidirectionally modulates macrophage polarization and epigenetically regulates macrophage memory. J Biol Chem. 2016;291(22):11491–503.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lloyd CM, Hessel EM. Functions of T cells in asthma: more than just T(H)2 cells. Nat Rev Immunol. 2010;10(12):838–48.
Article
CAS
PubMed
Google Scholar
Wang T, Zhong XG, Li YH, Jia X, Zhang SJ, Gao YS, et al. Protective effect of emodin against airway inflammation in the ovalbumin-induced mouse model. Chin J Integr Med. 2015;21(6):431–7.
Article
CAS
PubMed
Google Scholar
Golubovskaya V, Wu L. Different subsets of T cells, memory, effector functions, and CAR-T immunotherapy. Cancers. 2016;8(3):36.
Article
CAS
PubMed Central
Google Scholar
Sharma R, Tiku AB. Emodin inhibits splenocyte proliferation and inflammation by modulating cytokine responses in a mouse model system. J Immunotoxicol. 2016;13(1):20–6.
Article
CAS
PubMed
Google Scholar
Pyzik A, Grywalska E, Matyjaszek-Matuszek B, Rolinski J. Immune disorders in Hashimoto’s thyroiditis: what do we know so far? J Immunol Res. 2015;2015:979167.
Article
PubMed
PubMed Central
Google Scholar
Sun H, Ye Z, Li N, Jin F, Yan J, Wu K. Effect of emodin on T cell subsets in NOD mice with NaIinduced experimental autoimmune thyroiditis. Mol Med Rep. 2018;18(5):4303–12.
CAS
PubMed
PubMed Central
Google Scholar
Qiu F, Liu H, Liang CL, Nie GD, Dai Z. A New Immunosuppressive molecule emodin Induces both CD4(+)FoxP3(+) and CD8(+)CD122(+) regulatory T cells and suppresses murine allograft rejection. Front Immunol. 2017;8:1519.
Article
PubMed
PubMed Central
CAS
Google Scholar
Shang Y, Smith S, Hu X. Role of Notch signaling in regulating innate immunity and inflammation in health and disease. Protein Cell. 2016;7(3):159–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hua S, Liu F, Wang M. Emodin alleviates the airway inflammation of cough variant asthma in mice by regulating the notch pathway. Med Sci Monit. 2019;25:5621–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Papayannopoulos V. Neutrophil extracellular traps in immunity and disease. Nat Rev Immunol. 2018;18(2):134–47.
Article
CAS
PubMed
Google Scholar
Zhu M, Yuan K, Lu Q, Zhu Q, Zhang S, Li X, et al. Emodin ameliorates rheumatoid arthritis by promoting neutrophil apoptosis and inhibiting neutrophil extracellular trap formation. Mol Immunol. 2019;112:188–97.
Article
CAS
PubMed
Google Scholar
Wang GJ, Wang Y, Teng YS, Sun FL, Xiang H, Liu JJ, et al. Protective effects of emodin-induced neutrophil apoptosis via the Ca(2+)-caspase 12 pathway against SIRS in rats with severe acute pancreatitis. Biomed Res Int. 2016;2016:1736024.
PubMed
PubMed Central
Google Scholar
Ning JW, Zhang Y, Yu MS, Gu ML, Xu J, Usman A, et al. Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition. Hepatobiliary Pancreat Dis Inte. 2017;16(4):431–6.
Article
Google Scholar
Rockey DC, Bell PD, Hill JA. Fibrosis–a common pathway to organ injury and failure. N Engl J Med. 2015;372(12):1138–49.
Article
CAS
PubMed
Google Scholar
Meng XM, Nikolic-Paterson DJ, Lan HY. TGF-beta: the master regulator of fibrosis. Nat Rev Nephrol. 2016;12(6):325–38.
Article
CAS
PubMed
Google Scholar
Liu F, Zhang J, Qian J, Wu G, Ma Z. Emodin alleviates CCl4induced liver fibrosis by suppressing epithelialmesenchymal transition and transforming growth factorbeta1 in rats. Mol Med Rep. 2018;18(3):3262–70.
CAS
PubMed
PubMed Central
Google Scholar
Zhao XA, Chen G, Liu Y, Wu H, Chen J, Xiong Y, et al. Emodin alleviates liver fibrosis of mice by reducing infiltration of Gr1(hi) monocytes. Evid Based Complement Altern Med. 2018;2018:5738101.
Google Scholar
Wang X, Niu C, Zhang X, Dong M. Emodin suppresses activation of hepatic stellate cells through p38 mitogen-activated protein kinase and Smad signaling pathways in vitro. Phytother Res. 2018;32(12):2436–46.
Article
CAS
PubMed
Google Scholar
Guan R, Wang X, Zhao X, Song N, Zhu J, Wang J, et al. Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation. Sci Rep. 2016;6:35696.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang T, Wang J, Pang Y, Dang X, Ren H, Liu Y, et al. Emodin suppresses silica-induced lung fibrosis by promoting Sirt1 signaling via direct contact. Mol Med Rep. 2016;14(5):4643–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gao R, Chen R, Cao Y, Wang Y, Song K, Zhang Y, et al. Emodin suppresses TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells through Notch signaling pathway. Toxicol Appl Pharmacol. 2017;318:1–7.
Article
CAS
PubMed
Google Scholar
Zhou L, Gao R, Hong H, Li X, Yang J, Shen W, et al. Emodin inhibiting neutrophil elastase-induced epithelial-mesenchymal transition through Notch1 signalling in alveolar epithelial cells. J Cell Mol Med. 2020;24(20):11998–2007.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ma L, Li H, Zhang S, Xiong X, Chen K, Jiang P, et al. Emodin ameliorates renal fibrosis in rats via TGF-beta1/Smad signaling pathway and function study of Smurf 2. Int Urol Nephrol. 2018;50(2):373–82.
Article
CAS
PubMed
Google Scholar
Pechkovsky DV, Prele CM, Wong J, Hogaboam CM, McAnulty RJ, Laurent GJ, et al. STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF. Am J Pathol. 2012;180(4):1398–412.
Article
CAS
PubMed
Google Scholar
Guan R, Zhao X, Wang X, Song N, Guo Y, Yan X, et al. Emodin alleviates bleomycin-induced pulmonary fibrosis in rats. Toxicol Lett. 2016;262:161–72.
Article
CAS
PubMed
Google Scholar
Verfaillie T, Rubio N, Garg AD, Bultynck G, Rizzuto R, Decuypere JP, et al. PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress. Cell Death Differ. 2012;19(11):1880–91.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xiong G, Chen H, Wan Q, Dai J, Sun Y, Wang J, et al. Emodin promotes fibroblast apoptosis and prevents epidural fibrosis through PERK pathway in rats. J Orthop Surg Res. 2019;14(1):319.
Article
PubMed
PubMed Central
Google Scholar
Qin W, Du N, Zhang L, Wu X, Hu Y, Li X, et al. Genistein alleviates pressure overload-induced cardiac dysfunction and interstitial fibrosis in mice. Br J Pharmacol. 2015;172(23):5559–72.
Article
CAS
PubMed
PubMed Central
Google Scholar
Carver W, Fix E, Fix C, Fan D, Chakrabarti M, Azhar M. Effects of emodin, a plant-derived anthraquinone, on TGF-β1-induced cardiac fibroblast activation and function. J Cell Physiol. 2021. https://doi.org/10.1002/jcp.30416.
Article
PubMed
Google Scholar
Xiao D, Zhang Y, Wang R, Fu Y, Zhou T, Diao H, et al. Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3. Acta pharmaceutica Sinica B. 2019;9(4):724–33.
Article
PubMed
PubMed Central
Google Scholar
Pistritto G, Trisciuoglio D, Ceci C, Garufi A, D’Orazi G. Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies. Aging. 2016;8(4):603–19.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fang N, Zhang W, Xu S, Lin H, Wang Z, Liu H, et al. TRIB3 alters endoplasmic reticulum stress-induced beta-cell apoptosis via the NF-kappaB pathway. Metab Clin Exp. 2014;63(6):822–30.
Article
CAS
PubMed
Google Scholar
Su J, Yan Y, Qu J, Xue X, Liu Z, Cai H. Emodin induces apoptosis of lung cancer cells through ER stress and the TRIB3/NF-kappaB pathway. Oncol Rep. 2017;37(3):1565–72.
Article
PubMed
Google Scholar
Cui Y, Lu P, Song G, Liu Q, Zhu D, Liu X. Involvement of PI3K/Akt, ERK and p38 signaling pathways in emodin-mediated extrinsic and intrinsic human hepatoblastoma cell apoptosis. Food Chem Toxicol. 2016;92:26–37.
Article
CAS
PubMed
Google Scholar
Lin W, Zhong M, Yin H, Chen Y, Cao Q, Wang C, et al. Emodin induces hepatocellular carcinoma cell apoptosis through MAPK and PI3K/AKT signaling pathways in vitro and in vivo. Oncol Rep. 2016;36(2):961–7.
Article
CAS
PubMed
Google Scholar
Zhang L, He D, Li K, Liu H, Wang B, Zheng L, et al. Emodin targets mitochondrial cyclophilin D to induce apoptosis in HepG2 cells. Biomed Pharmacother. 2017;90:222–8.
Article
CAS
PubMed
Google Scholar
Ashkenazi A, Fairbrother WJ, Leverson JD, Souers AJ. From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors. Nat Rev Drug Discovery. 2017;16(4):273–84.
Article
CAS
PubMed
Google Scholar
Saunders IT, Mir H, Kapur N, Singh S. Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways. Cancer Cell Int. 2019;19:98.
Article
PubMed
PubMed Central
Google Scholar
Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer. Nat Rev Cancer. 2017;17(9):528–42.
Article
CAS
PubMed
Google Scholar
Wang Y, Luo Q, He X, Wei H, Wang T, Shao J, et al. Emodin induces apoptosis of colon cancer cells via induction of autophagy in a ROS-dependent manner. Oncol Res. 2018;26(6):889–99.
Article
PubMed
PubMed Central
Google Scholar
Trybus W, Krol T, Trybus E, Kopacz-Bednarska A, Krol G, Karpowicz E. Changes in the lysosomal system of cervical cancer cells induced by emodin action. Anticancer Res. 2017;37(11):6087–96.
CAS
PubMed
Google Scholar
Zhou J, Li G, Han G, Feng S, Liu Y, Chen J, et al. Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway. Invest New Drugs. 2020;38(1):50–9.
Article
CAS
PubMed
Google Scholar
Janssen A, Medema RH. Mitosis as an anti-cancer target. Oncogene. 2011;30(25):2799–809.
Article
CAS
PubMed
Google Scholar
Recasens A, Munoz L. Targeting cancer cell dormancy. Trends Pharmacol Sci. 2019;40(2):128–41.
Article
CAS
PubMed
Google Scholar
Wang Y, Yu H, Zhang J, Ge X, Gao J, Zhang Y, et al. Anti-tumor effect of emodin on gynecological cancer cells. Cell Oncol. 2015;38(5):353–63.
Article
CAS
Google Scholar
Trybus W, Krol T, Trybus E, Stachurska A, Krol G, Kopacz-Bednarska A. Emodin induces death in human cervical cancer cells through mitotic catastrophe. Anticancer Res. 2019;39(2):679–86.
Article
CAS
PubMed
Google Scholar
Deng G, Ju X, Meng Q, Yu ZJ, Ma LB. Emodin inhibits the proliferation of PC3 prostate cancer cells in vitro via the Notch signaling pathway. Mol Med Rep. 2015;12(3):4427–33.
Article
CAS
PubMed
Google Scholar
Haque E, Kamil M, Irfan S, Sheikh S, Hasan A, Nazir A, et al. Blocking mutation independent p53 aggregation by emodin modulates autophagic cell death pathway in lung cancer. Int J Biochem Cell Biol. 2018;96:90–5.
Article
CAS
PubMed
Google Scholar
Chen Y, Mei X, Gan D, Wu Z, Cao Y, Lin M, et al. Integration of bioinformatics and experiments to identify TP53 as a potential target in Emodin inhibiting diffuse large B cell lymphoma. Biomed Pharmacother. 2018;107:226–33.
Article
CAS
PubMed
Google Scholar
Navarro F, Lieberman J. miR-34 and p53: new Insights into a complex functional relationship. PloS ONE. 2015;10(7):e0132767.
Article
PubMed
PubMed Central
CAS
Google Scholar
Bai J, Wu J, Tang R, Sun C, Ji J, Yin Z, et al. Emodin, a natural anthraquinone, suppresses liver cancer in vitro and in vivo by regulating VEGFR(2) and miR-34a. Invest New Drugs. 2020;38(2):229–45.
Article
CAS
PubMed
Google Scholar
Dai G, Ding K, Cao Q, Xu T, He F, Liu S, et al. Emodin suppresses growth and invasion of colorectal cancer cells by inhibiting VEGFR2. Eur J Pharmacol. 2019;859:172525.
Article
CAS
PubMed
Google Scholar
Masoud GN, Li W. HIF-1α pathway: role, regulation and intervention for cancer therapy. Acta pharmaceutica Sinica B. 2015;5(5):378–89.
Article
PubMed
PubMed Central
Google Scholar
Ma F, Hu L, Yu M, Wang F. Emodin decreases hepatic hypoxia-inducible factor-1[Formula: see text] by inhibiting its biosynthesis. Am J Chin Med. 2016;44(5):997–1008.
Article
CAS
PubMed
Google Scholar
Zheng CC, Hu HF, Hong P, Zhang QH, Xu WW, He QY, et al. Significance of integrin-linked kinase (ILK) in tumorigenesis and its potential implication as a biomarker and therapeutic target for human cancer. Am J Cancer Res. 2019;9(1):186–97.
CAS
PubMed
PubMed Central
Google Scholar
Tang Q, Zhao S, Wu J, Zheng F, Yang L, Hu J, et al. Inhibition of integrin-linked kinase expression by emodin through crosstalk of AMPKα and ERK1/2 signaling and reciprocal interplay of Sp1 and c-Jun. Cell Signal. 2015;27(7):1469–77.
Article
CAS
PubMed
Google Scholar
Zhang H, Chen L, Bu HQ, Yu QJ, Jiang DD, Pan FP, et al. Effects of emodin on the demethylation of tumor-suppressor genes in pancreatic cancer PANC-1 cells. Oncol Rep. 2015;33(6):3015–23.
Article
CAS
PubMed
Google Scholar
Zhou RS, Wang XW, Sun QF, Ye ZJ, Liu JW, Zhou DH, et al. Anticancer effects of emodin on HepG2 cell: evidence from bioinformatic analysis. Biomed Res Int. 2019;2019:3065818.
PubMed
PubMed Central
Google Scholar
Pastushenko I, Blanpain C. EMT transition states during tumor progression and metastasis. Trends Cell Biol. 2019;29(3):212–26.
Article
CAS
PubMed
Google Scholar
Li N, Wang C, Zhang P, You S. Emodin inhibits pancreatic cancer EMT and invasion by upregulating microRNA1271. Mol Med Rep. 2018;18(3):3366–74.
CAS
PubMed
PubMed Central
Google Scholar
Lin SZ, Xu JB, Ji X, Chen H, Xu HT, Hu P, et al. Emodin inhibits angiogenesis in pancreatic cancer by regulating the transforming growth factor-β/drosophila mothers against decapentaplegic pathway and angiogenesis-associated microRNAs. Mol Med Rep. 2015;12(4):5865–71.
Article
CAS
PubMed
Google Scholar
Song K, Lv T, Chen Y, Diao Y, Yao Q, Wang Y. Emodin inhibits TGF-β2 by activating the FOXD3/miR-199a axis in ovarian cancer cells in vitro. Oncol Rep. 2018;39(5):2063–70.
CAS
PubMed
PubMed Central
Google Scholar
Hsu HC, Liu LC, Wang HY, Hung CM, Lin YC, Ho CT, et al. Stromal fibroblasts from the interface zone of triple negative breast carcinomas induced epithelial-mesenchymal transition and its inhibition by emodin. PloS ONE. 2017;12(1):e0164661.
Article
PubMed
PubMed Central
CAS
Google Scholar
Song X, Zhou X, Qin Y, Yang J, Wang Y, Sun Z, et al. Emodin inhibits epithelialmesenchymal transition and metastasis of triple negative breast cancer via antagonism of CCchemokine ligand 5 secreted from adipocytes. Int J Mol Med. 2018;42(1):579–88.
CAS
PubMed
Google Scholar
Li Q, Lai Q, He C, Fang Y, Yan Q, Zhang Y, et al. RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer. J Exp Clin Cancer Res. 2019;38(1):334.
Article
PubMed
PubMed Central
CAS
Google Scholar
Liang Z, Lu L, Mao J, Li X, Qian H, Xu W. Curcumin reversed chronic tobacco smoke exposure induced urocystic EMT and acquisition of cancer stem cells properties via Wnt/β-catenin. Cell Death Dis. 2017;8(10):e3066.
Article
PubMed
PubMed Central
Google Scholar
Gu J, Cui CF, Yang L, Wang L, Jiang XH. Emodin Inhibits colon cancer cell invasion and migration by suppressing epithelial-mesenchymal transition via the Wnt/beta-catenin pathway. Oncol Res. 2019;27(2):193–202.
Article
PubMed
PubMed Central
Google Scholar
Hu C, Dong T, Li R, Lu J, Wei X, Liu P. Emodin inhibits epithelial to mesenchymal transition in epithelial ovarian cancer cells by regulation of GSK-3beta/beta-catenin/ZEB1 signaling pathway. Oncol Rep. 2016;35(4):2027–34.
Article
CAS
PubMed
Google Scholar
Lu J, Xu Y, Zhao Z, Ke X, Wei X, Kang J, et al. Emodin suppresses proliferation, migration and invasion in ovarian cancer cells by down regulating ILK in vitro and in vivo. Onco Targets Ther. 2017;10:3579–89.
Article
PubMed
PubMed Central
Google Scholar
Lu J, Xu Y, Wei X, Zhao Z, Xue J, Liu P. Emodin inhibits the epithelial to mesenchymal transition of epithelial ovarian cancer cells via ILK/GSK-3beta/Slug signaling pathway. Biomed Res Int. 2016;2016:6253280.
PubMed
PubMed Central
Google Scholar
Sun H, Li XB, Meng Y, Fan L, Li M, Fang J. TRAF6 upregulates expression of HIF-1alpha and promotes tumor angiogenesis. Can Res. 2013;73(15):4950–9.
Article
CAS
Google Scholar
Gabison EE, Hoang-Xuan T, Mauviel A, Menashi S. EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair. Biochimie. 2005;87(3–4):361–8.
Article
CAS
PubMed
Google Scholar
Shi GH, Zhou L. Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6-mediated pathways in vivo and in vitro. Mol Med Rep. 2018;18(6):5191–7.
CAS
PubMed
Google Scholar
Lin W, Zhong M, Liang S, Chen Y, Liu D, Yin Z, et al. Emodin inhibits migration and invasion of MHCC-97H human hepatocellular carcinoma cells. Exp Ther Med. 2016;12(5):3369–74.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kim JM, Noh EM, Song HK, You YO, Jung SH, Kim JS, et al. Silencing of casein kinase 2 inhibits PKC-induced cell invasion by targeting MMP-9 in MCF-7 cells. Mol Med Rep. 2018;17(6):8397–402.
CAS
PubMed
Google Scholar
Su S, Liu Q, Chen J, Chen J, Chen F, He C, et al. A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis. Cancer Cell. 2014;25(5):605–20.
Article
PubMed
CAS
Google Scholar
Iwanowycz S, Wang J, Hodge J, Wang Y, Yu F, Fan D. Emodin inhibits breast cancer growth by blocking the tumor-promoting feedforward loop between cancer cells and macrophages. Mol Cancer Ther. 2016;15(8):1931–42.
Article
CAS
PubMed
PubMed Central
Google Scholar
Liu Q, Hodge J, Wang J, Wang Y, Wang L, Singh U, et al. Emodin reduces breast cancer lung metastasis by suppressing macrophage-induced breast cancer cell epithelial-mesenchymal transition and cancer stem cell formation. Theranostics. 2020;10(18):8365–81.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gao J, Zheng Q, Xin N, Wang W, Zhao C. CD155, an onco-immunologic molecule in human tumors. Cancer Sci. 2017;108(10):1934–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fang L, Zhao F, Iwanowycz S, Wang J, Yin S, Wang Y, et al. Anticancer activity of emodin is associated with downregulation of CD155. Int Immunopharmacol. 2019;75:105763.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fridlender ZG, Sun J, Kim S, Kapoor V, Cheng G, Ling L, et al. Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN. Cancer Cell. 2009;16(3):183–94.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li Z, Lin Y, Zhang S, Zhou L, Yan G, Wang Y, et al. Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis. J Transl Med. 2019;17(1):90.
Article
PubMed
PubMed Central
Google Scholar
Keating GM. Sorafenib: a review in hepatocellular carcinoma. Target Oncol. 2017;12(2):243–53.
Article
PubMed
Google Scholar
Kim YS, Lee YM, Oh TI, Shin DH, Kim GH, Kan SY, et al. Emodin sensitizes hepatocellular carcinoma cells to the anti-cancer effect of sorafenib through suppression of cholesterol metabolism. Int J Mol Sci. 2018;19(10):3127.
Article
PubMed Central
CAS
Google Scholar
Chen S, Zhang Z, Zhang J. Emodin enhances antitumor effect of paclitaxel on human non-small-cell lung cancer cells in vitro and in vivo. Drug Des Dev Ther. 2019;13:1145–53.
Article
CAS
Google Scholar
Phng LK, Potente M, Leslie JD, Babbage J, Nyqvist D, Lobov I, et al. Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell. 2009;16(1):70–82.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zu C, Qin G, Yang C, Liu N, He A, Zhang M, et al. Low dose emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP. Biochem Biophys Res Commun. 2018;505(4):973–8.
Article
CAS
PubMed
Google Scholar
Pan FP, Zhou HK, Bu HQ, Chen ZQ, Zhang H, Xu LP, et al. Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK. Oncol Rep. 2016;35(4):1941–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Thomas NA, Abraham RG, Dedi B, Krucher NA. Targeting retinoblastoma protein phosphorylation in combination with EGFR inhibition in pancreatic cancer cells. Int J Oncol. 2019;54(2):527–36.
CAS
PubMed
Google Scholar
Wang Z, Chen H, Chen J, Hong Z, Liao Y, Zhang Q, et al. Emodin sensitizes human pancreatic cancer cells to EGFR inhibitor through suppressing Stat3 signaling pathway. Cancer Manag Res. 2019;11:8463–73.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hintzpeter J, Seliger JM, Hofman J, Martin HJ, Wsol V, Maser E. Inhibition of human anthracycline reductases by emodin—a possible remedy for anthracycline resistance. Toxicol Appl Pharmacol. 2016;293:21–9.
Article
CAS
PubMed
Google Scholar
Li X, Wang H, Wang J, Chen Y, Yin X, Shi G, et al. Emodin enhances cisplatin-induced cytotoxicity in human bladder cancer cells through ROS elevation and MRP1 downregulation. BMC Cancer. 2016;16:578.
Article
PubMed
PubMed Central
CAS
Google Scholar
Iyer VV, Priya PY, Kangeyavelu J. Effects of increased accumulation of doxorubicin due to emodin on efflux transporter and LRP1 expression in lung adenocarcinoma and colorectal carcinoma cells. Mol Cell Biochem. 2018;449(1–2):91–104.
Article
CAS
PubMed
Google Scholar
Batista MN, Braga ACS, Campos GRF, Souza MM, Matos RPA, Lopes TZ, et al. Natural products isolated from oriental medicinal herbs inactivate Zika virus. Viruses. 2019;11(1):49.
Article
CAS
PubMed Central
Google Scholar
Dai JP, Wang QW, Su Y, Gu LM, Zhao Y, Chen XX, et al. Emodin inhibition of influenza A virus replication and influenza viral pneumonia via the Nrf2, TLR4, p38/JNK and NF-kappaB pathways. Molecules. 2017;22(10):1754.
Article
PubMed Central
CAS
Google Scholar
Zhong T, Zhang LY, Wang ZY, Wang Y, Song FM, Zhang YH, et al. Rheum emodin inhibits enterovirus 71 viral replication and affects the host cell cycle environment. Acta Pharmacol Sin. 2017;38(3):392–401.
Article
CAS
PubMed
Google Scholar
Zhang HM, Wang F, Qiu Y, Ye X, Hanson P, Shen H, et al. Emodin inhibits coxsackievirus B3 replication via multiple signalling cascades leading to suppression of translation. Biochem J. 2016;473(4):473–85.
Article
CAS
PubMed
Google Scholar
Hall CW, Mah TF. Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria. FEMS Microbiol Rev. 2017;41(3):276–301.
Article
CAS
PubMed
Google Scholar
Yang YB, Wang S, Wang C, Huang QY, Bai JW, Chen JQ, et al. Emodin affects biofilm formation and expression of virulence factors in Streptococcus suis ATCC700794. Arch Microbiol. 2015;197(10):1173–80.
Article
CAS
PubMed
Google Scholar
Yan X, Gu S, Shi Y, Cui X, Wen S, Ge J. The effect of emodin on Staphylococcus aureus strains in planktonic form and biofilm formation in vitro. Arch Microbiol. 2017;199(9):1267–75.
Article
CAS
PubMed
Google Scholar
Liu M, Peng W, Qin R, Yan Z, Cen Y, Zheng X, et al. The direct anti-MRSA effect of emodin via damaging cell membrane. Appl Microbiol Biotechnol. 2015;99(18):7699–709.
Article
CAS
PubMed
Google Scholar
Ji X, Liu X, Peng Y, Zhan R, Xu H, Ge X. Comparative analysis of methicillin-sensitive and resistant Staphylococcus aureus exposed to emodin based on proteomic profiling. Biochem Biophys Res Commun. 2017;494(1–2):318–24.
Article
CAS
PubMed
Google Scholar
Li L, Tian Y, Yu J, Song X, Jia R, Cui Q, et al. iTRAQ-based quantitative proteomic analysis reveals multiple effects of emodin to Haemophilus parasuis. J Proteomics. 2017;166:39–47.
Article
CAS
PubMed
Google Scholar
Harikrishnan R, Jawahar S, Thamizharasan S, Paray BA, Al-Sadoon MK, Balasundaram C. Immune defense of emodin enriched diet in Clarias batrachus against Aeromonas hydrophila. Fish Shellfish Immunol. 2018;76:13–20.
Article
CAS
PubMed
Google Scholar
Jung HA, Ali MY, Choi JS. Promising inhibitory effects of anthraquinones, naphthopyrone, and naphthalene glycosides, from Cassia obtusifolia on α-glucosidase and human protein tyrosine phosphatases 1B. Molecules. 2016;22(1):28.
Article
PubMed Central
CAS
Google Scholar
Arvindekar A, More T, Payghan PV, Laddha K, Ghoshal N, Arvindekar A. Evaluation of anti-diabetic and alpha glucosidase inhibitory action of anthraquinones from Rheum emodi. Food Funct. 2015;6(8):2693–700.
Article
CAS
PubMed
Google Scholar
Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM, et al. Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome. Diabetes. 2011;60(7):1917–25.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang Z, Yang L, Fan H, Wu P, Zhang F, Zhang C, et al. Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4. PeerJ. 2017;5:e3283.
Article
PubMed
PubMed Central
CAS
Google Scholar
Yu L, Gong L, Wang C, Hu N, Tang Y, Zheng L, et al. Radix polygoni multiflori and its main component emodin attenuate non-alcoholic fatty liver disease in zebrafish by regulation of AMPK signaling pathway. Drug Des Dev Ther. 2020;14:1493–506.
Article
CAS
Google Scholar
Zhang X, Zhang R, Lv P, Yang J, Deng Y, Xu J, et al. Emodin up-regulates glucose metabolism, decreases lipolysis, and attenuates inflammation in vitro. J Diabetes. 2015;7(3):360–8.
Article
CAS
PubMed
Google Scholar
Wang S, Li X, Guo H, Yuan Z, Wang T, Zhang L, et al. Emodin alleviates hepatic steatosis by inhibiting sterol regulatory element binding protein 1 activity by way of the calcium/calmodulin-dependent kinase kinase-AMP-activated protein kinase-mechanistic target of rapamycin-p70 ribosomal S6 kinase signaling pathway. Hepatol Res. 2017;47(7):683–701.
Article
CAS
PubMed
Google Scholar
Li X, Xu Z, Wang S, Guo H, Dong S, Wang T, et al. Emodin ameliorates hepatic steatosis through endoplasmic reticulum-stress sterol regulatory element-binding protein 1c pathway in liquid fructose-feeding rats. Hepatol Res. 2016;46(3):E105-117.
Article
CAS
PubMed
Google Scholar
Shimano H, Sato R. SREBP-regulated lipid metabolism: convergent physiology—divergent pathophysiology. Nat Rev Endocrinol. 2017;13(12):710–30.
Article
CAS
PubMed
Google Scholar
Li J, Ding L, Song B, Xiao X, Qi M, Yang Q, et al. Emodin improves lipid and glucose metabolism in high fat diet-induced obese mice through regulating SREBP pathway. Eur J Pharmacol. 2016;770:99–109.
Article
CAS
PubMed
Google Scholar
Xiao D, Hu Y, Fu Y, Wang R, Zhang H, Li M, et al. Emodin improves glucose metabolism by targeting microRNA-20b in insulin-resistant skeletal muscle. Phytomedicine. 2019;59:152758.
Article
CAS
PubMed
Google Scholar
Cao Y, Chang S, Dong J, Zhu S, Zheng X, Li J, et al. Emodin ameliorates high-fat-diet induced insulin resistance in rats by reducing lipid accumulation in skeletal muscle. Eur J Pharmacol. 2016;780:194–201.
Article
CAS
PubMed
Google Scholar
Cheng L, Zhang S, Shang F, Ning Y, Huang Z, He R, et al. Emodin improves glucose and lipid metabolism disorders in obese mice via activating brown adipose tissue and inducing browning of white adipose tissue. Front Endocrinol. 2021;12:618037.
Article
Google Scholar
Abu Eid S, Adams M, Scherer T, Torres-Gómez H, Hackl MT, Kaplanian M, et al. Emodin, a compound with putative antidiabetic potential, deteriorates glucose tolerance in rodents. Eur J Pharmacol. 2017;798:77–84.
Article
CAS
PubMed
Google Scholar
Quattrini L, La Motta C. Aldose reductase inhibitors: 2013-present. Expert Opin Ther Pat. 2019;29(3):199–213.
Article
CAS
PubMed
Google Scholar
Tian N, Gao Y, Wang X, Wu X, Zou D, Zhu Z, et al. Emodin mitigates podocytes apoptosis induced by endoplasmic reticulum stress through the inhibition of the PERK pathway in diabetic nephropathy. Drug Des Dev Ther. 2018;12:2195–211.
Article
CAS
Google Scholar
Jing D, Bai H, Yin S. Renoprotective effects of emodin against diabetic nephropathy in rat models are mediated via PI3K/Akt/GSK-3β and Bax/caspase-3 signaling pathways. Exp Ther Med. 2017;14(5):5163–9.
CAS
PubMed
PubMed Central
Google Scholar
Xu S, Lv Y, Zhao J, Wang J, Zhao X, Wang S. Inhibitory effects of Shenkang injection and its main component emodin on the proliferation of high glucose-induced renal mesangial cells through cell cycle regulation and induction of apoptosis. Mol Med Rep. 2016;14(4):3381–8.
Article
CAS
PubMed
Google Scholar
Schalkwijk CG, Stehouwer CDA. Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases. Physiol Rev. 2020;100(1):407–61.
Article
CAS
PubMed
Google Scholar
Sohn E, Kim J, Kim CS, Jo K, Kim JS. Extract of Rhizoma Polygonum cuspidatum reduces early renal podocyte injury in streptozotocin-induced diabetic rats and its active compound emodin inhibits methylglyoxal-mediated glycation of proteins. Mol Med Rep. 2015;12(4):5837–45.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fan L, Zhang H, Li X, Yang G, Ru J, Liu T. Emodin protects hyperglycemia-induced injury in PC-12 cells by up-regulation of miR-9. Mol Cell Endocrinol. 2018;474:194–200.
Article
CAS
PubMed
Google Scholar
Zhang Y, Yang X, Jia Z, Liu J, Yan X, Dai Y, et al. Proteomics unravels emodin causes liver oxidative damage elicited by mitochondrial dysfunction. Front Pharmacol. 2020;11:416.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen C, Gao J, Wang TS, Guo C, Yan YJ, Mao CY, et al. NMR-based metabolomic techniques identify the toxicity of emodin in HepG2 cells. Sci Rep. 2018;8(1):9379.
Article
PubMed
PubMed Central
CAS
Google Scholar
Luo T, Li N, He YQ, Weng SQ, Wang T, Zou QX, et al. Emodin inhibits human sperm functions by reducing sperm [Ca(2+)]i and tyrosine phosphorylation. Reprod Toxicol. 2015;51:14–21.
Article
CAS
PubMed
Google Scholar
Teng Z, Yuan C, Zhang F, Huan M, Cao W, Li K, et al. Intestinal absorption and first-pass metabolism of polyphenol compounds in rat and their transport dynamics in Caco-2 cells. PloS ONE. 2012;7(1):e29647.
Article
CAS
PubMed
PubMed Central
Google Scholar
Qin B, Xu Y, Chen J, Huang W, Peng Y, Zheng J. Chemical reactivity of emodin and its oxidative metabolites to thiols. Chem Res Toxicol. 2016;29(12):2114–24.
Article
CAS
PubMed
Google Scholar
Xu Y, Wang Q, Yin Z, Gao X. On-line incubation and real-time detection by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry for rapidly analyzing metabolites of anthraquinones in rat liver microsomes. J Chromatogr A. 2018;1571:94–106.
Article
CAS
PubMed
Google Scholar
Huang Z, Xu Y, Wang Q, Gao X. Metabolism and mutual biotransformations of anthraquinones and anthrones in rhubarb by human intestinal flora using UPLC-Q-TOF/MS. J Chromatogr B. 2019;1104:59–66.
Article
CAS
Google Scholar
Park B, Yoon W, Yun J, Ban E, Yun H, Kim A. Emodin-nicotinamide (1:2) cocrystal identified by thermal screening to improve emodin solubility. Int J Pharm. 2019;557:26–35.
Article
CAS
PubMed
Google Scholar
Liu W, Tang L, Ye L, Cai Z, Xia B, Zhang J, et al. Species and gender differences affect the metabolism of emodin via glucuronidation. AAPS J. 2010;12(3):424–36.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ban E, Park M, Jeong S, Kwon T, Kim EH, Jung K, et al. Poloxamer-based thermoreversible gel for topical delivery of emodin: influence of P407 and P188 on solubility of emodin and its application in cellular activity screening. Molecules. 2017;22(2):246.
Article
PubMed Central
CAS
Google Scholar
Campos PP, Fraceto LF, Ferreira M. Layer-by-layer films containing emodin or emodin encapsulated in liposomes for transdermal applications. Colloids Surf B. 2018;162:69–75.
Article
CAS
Google Scholar
Wei W, Meng C, Wang Y, Huang Y, Du W, Li H, et al. The interaction between self—assembling peptides and emodin and the controlled release of emodin from in-situ hydrogel. Artif Cells Nanomed Biotechnol. 2019;47(1):3961–75.
Article
CAS
PubMed
Google Scholar
Huang J, Gong W, Chen Z, Huang J, Chen Q, Huang H, et al. Emodin self-emulsifying platform ameliorates the expression of FN, ICAM-1 and TGF-β1 in AGEs-induced glomerular mesangial cells by promoting absorption. Eur J Pharm Sci. 2017;99:128–36.
Article
CAS
PubMed
Google Scholar
Liu W, Feng Q, Li Y, Ye L, Hu M, Liu Z. Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin. Toxicol Appl Pharmacol. 2012;265(3):316–24.
Article
CAS
PubMed
Google Scholar
Wu W, Hu N, Zhang Q, Li Y, Li P, Yan R, et al. In vitro glucuronidation of five rhubarb anthraquinones by intestinal and liver microsomes from humans and rats. Chem Biol Interact. 2014;219:18–27.
Article
CAS
PubMed
Google Scholar
Zhang T, Dong D, Lu D, Wang S, Wu B. Cremophor EL-based nanoemulsion enhances transcellular permeation of emodin through glucuronidation reduction in UGT1A1-overexpressing MDCKII cells. Int J Pharm. 2016;501(1–2):190–8.
Article
CAS
PubMed
Google Scholar
Akkol EK, Tatlı II, Karatoprak G, Ağar OT, Yücel Ç, Sobarzo-Sánchez E, et al. Is emodin with anticancer effects completely innocent? Two sides of the coin. Cancers. 2021;13(11):2733.
Article
PubMed
PubMed Central
Google Scholar
Yang K, Jin MJ, Quan ZS, Piao HR. Design and synthesis of novel anti-proliferative emodin derivatives and studies on their cell cycle arrest, apoptosis pathway and migration. Molecules. 2019;24(5):884.
Article
PubMed Central
CAS
Google Scholar
Khan H, Jia W, Yu Z, Zaib T, Feng J, Jiang Y, et al. Emodin succinyl ester inhibits malignant proliferation and migration of hepatocellular carcinoma by suppressing the interaction of AR and EZH2. Biomed Pharmacother. 2020;128:110244.
Article
CAS
PubMed
Google Scholar
Koerner SK, Hanai JI, Bai S, Jernigan FE, Oki M, Komaba C, et al. Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase. Eur J Med Chem. 2017;126:920–8.
Article
CAS
PubMed
Google Scholar
Chen Y, Zheng J, Gan D, Chen Y, Zhang N, Chen Y, et al. E35 ablates acute leukemia stem and progenitor cells in vitro and in vivo. J Cell Physiol. 2020;235(11):8023–34.
Article
CAS
PubMed
PubMed Central
Google Scholar
Malam Y, Loizidou M, Seifalian AM. Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol Sci. 2009;30(11):592–9.
Article
CAS
PubMed
Google Scholar
Liu H, Gao M, Xu H, Guan X, Lv L, Deng S, et al. A Promising emodin-loaded poly (lactic-co-glycolic Acid)-d-α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for liver cancer therapy. Pharm Res. 2016;33(1):217–36.
Article
CAS
PubMed
Google Scholar
Dong H, Wu G, Xu H, Zhang C, Wang J, Gao M, et al. N-acetylaminogalactosyl-decorated biodegradable PLGA-TPGS copolymer nanoparticles containing emodin for the active targeting therapy of liver cancer. Artif Cells Nanomed Biotechnol. 2018;46(sup2):260–72.
Article
CAS
PubMed
Google Scholar
Wang D, Sun M, Zhang Y, Chen Z, Zang S, Li G, et al. Enhanced therapeutic efficacy of a novel colon-specific nanosystem loading emodin on DSS-induced experimental colitis. Phytomedicine. 2020;78:153293.
Article
CAS
PubMed
Google Scholar
Ding W, Sun J, Lian H, Xu C, Liu X, Zheng S, et al. The Influence of shuttle-shape emodin nanoparticles on the Streptococcus suis Biofilm. Front Pharmacol. 2018;9:227.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ye P, Wei S, Luo C, Wang Q, Li A, Wei F. Long-term Effect against methicillin-resistant Staphylococcus aureus of emodin released from coaxial electrospinning nanofiber membranes with a biphasic profile. Biomolecules. 2020;10(3):362.
Article
CAS
PubMed Central
Google Scholar
Li H, Yang T, Zhou H, Du J, Zhu B, Sun Z. Emodin combined with nanosilver inhibited sepsis by anti-inflammatory protection. Front Pharmacol. 2016;7:536.
PubMed
Google Scholar
Fu M, Tang W, Liu JJ, Gong XQ, Kong L, Yao XM, et al. Combination of targeted daunorubicin liposomes and targeted emodin liposomes for treatment of invasive breast cancer. J Drug Target. 2020;28(3):245–58.
Article
CAS
PubMed
Google Scholar
Liu H, Zhuang Y, Wang P, Zou T, Lan M, Li L, et al. Polymeric lipid hybrid nanoparticles as a delivery system enhance the antitumor effect of emodin in vitro and in vivo. J Pharm Sci. 2021;110(8):2986–96.
Article
CAS
PubMed
Google Scholar
Song Y, Sheng Z, Xu Y, Dong L, Xu W, Li F, et al. Magnetic liposomal emodin composite with enhanced killing efficiency against breast cancer. Biomater Sci. 2019;7(3):867–75.
Article
CAS
PubMed
Google Scholar
Wu W, Yan R, Yao M, Zhan Y, Wang Y. Pharmacokinetics of anthraquinones in rat plasma after oral administration of a rhubarb extract. Biomed Chromatogr. 2014;28(4):564–72.
Article
CAS
PubMed
Google Scholar
Liu W, Zheng Z, Liu X, Gao S, Ye L, Yang Z, et al. Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide. J Pharm Biomed Anal. 2011;54(5):1157–62.
Article
PubMed
CAS
Google Scholar
Yu F, Yu N, Peng J, Zhao Y, Zhang L, Wang X, et al. Emodin inhibits lipid accumulation and inflammation in adipose tissue of high-fat diet-fed mice by inducing M2 polarization of adipose tissue macrophages. FASEB J. 2021;35(7):e21730.
Article
CAS
PubMed
Google Scholar
Kon R, Ikarashi N, Nagoya C, Takayama T, Kusunoki Y, Ishii M, et al. Rheinanthrone, a metabolite of sennoside A, triggers macrophage activation to decrease aquaporin-3 expression in the colon, causing the laxative effect of rhubarb extract. J Ethnopharmacol. 2014;152(1):190–200.
Article
CAS
PubMed
Google Scholar
Zeng YQ, Dai Z, Lu F, Lu Z, Liu X, Chen C, et al. Emodin via colonic irrigation modulates gut microbiota and reduces uremic toxins in rats with chronic kidney disease. Oncotarget. 2016;7(14):17468–78.
Article
PubMed
PubMed Central
Google Scholar
Liu B, Piao X, Niu W, Zhang Q, Ma C, Wu T, et al. Kuijieyuan decoction improved intestinal barrier injury of ulcerative colitis by affecting TLR4-dependent PI3K/AKT/NF-κB oxidative and inflammatory signaling and gut microbiota. Front Pharmacol. 2020;11:1036.
Article
CAS
PubMed
PubMed Central
Google Scholar
Baruch EN, Youngster I, Ben-Betzalel G, Ortenberg R, Lahat A, Katz L, et al. Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients. Science. 2021;371(6529):602–9.
Article
CAS
PubMed
Google Scholar