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  1. Research

    Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro

    Bromelain, which is a cysteine endopeptidase commonly found in pineapple stems, has been investigated as a potential anti-cancer agent for the treatment of breast cancer. However, information pertaining to the...

    Ahmad Zaim Mat Pauzi, Swee Keong Yeap, Nadiah Abu, Kian Lam Lim, Abdul Rahman Omar, Suraini Abdul Aziz, Adam Leow Thean Chow, Tamilselvan Subramani, Soon Guan Tan and Noorjahan Banu Alitheen

    Chinese Medicine 2016 11:46

    Published on: 15 November 2016

  2. Research

    Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability

    Trans-ferulic (FA) acid exhibits antioxidant effects in vitro. However, the underlying mechanism of trans-FA activity in cellular physiology, especially cancer physiology, remains larg...

    Yao Fong, Chia-Chun Tang, Huei-Ting Hu, Hsin-Yu Fang, Bing-Hung Chen, Chang-Yi Wu, Shyng-Shiou Yuan, Hui-Min David Wang, Yen-Chun Chen, Yen-Ni Teng and Chien-Chih Chiu

    Chinese Medicine 2016 11:45

    Published on: 1 October 2016

  3. Research

    Full component analysis of Tianma-Gouteng-Yin

    Tianma-Gouteng-Yin (TGY), which is common Chinese medicine formulation consisting of 11 different herbs and being used in China for the treatment of Parkinson’s disease, inflammatory c...

    Ying-Yu Huang, Liang-Feng Liu, Rui-Qi Yue, Jun Xu, Alan Ho, Min Li and Quan-Bin Han

    Chinese Medicine 2016 11:44

    Published on: 29 September 2016

  4. Research

    Authentication of Acori Tatarinowii Rhizoma (Shi Chang Pu) and its adulterants by morphological distinction, chemical composition and ITS sequencing

    Acori Tatarinowii Rhizoma (ATR; rhizome of Acorus tatarinowii Schott) (Shi Chang Pu) is widely used in Chinese medicine (CM) to resuscitate, calm the mind, resolve shi (dampness) and harmonize the wei (stomach). ...

    Kelly Yin-Ching Lam, Chuen-Fai Ku, Huai-You Wang, Gallant Kar-Lun Chan, Ping Yao, Huang-Quan Lin, Tina Ting-Xia Dong, Hong-Jie Zhang and Karl Wah-Keung Tsim

    Chinese Medicine 2016 11:41

    Published on: 26 September 2016

  5. Research

    Adjunctive use of modified Yunu-Jian in the non-surgical treatment of male smokers with chronic periodontitis: a randomized double-blind, placebo-controlled clinical trial

    Yunu-Jian (YJ) is a Chinese medicine (CM) heat purging formula, which is used to reduce wei huo (stomach-heat, SH) and enrich shen yin (kidney-yin, KY). This formula is also commonly u...

    Kwan-Yat Zee, Pui Sze Chan, Johnson Chun Sing Ho, Stanley Man Lung Lai, Esmonde Francis Corbet and Wai Keung Leung

    Chinese Medicine 2016 11:40

    Published on: 20 September 2016

  6. Research

    Chi-Ju-Di-Huang-Wan protects rats against retinal ischemia by downregulating matrix metalloproteinase-9 and inhibiting p38 mitogen-activated protein kinase

    Retinal ischemia is a retinal disorder related to retinal vascular occlusion, glaucoma, diabetic retinopathy and age-related macular degeneration. The study aimed to evaluate the protective effects and underly...

    Ji-Min Cheng, Xiao-Qian Liu, Jorn-Hon Liu, Wynn Hwai-Tzong Pan, Xiu-Mei Zhang, Lei Hu and Hsiao-Ming Chao

    Chinese Medicine 2016 11:39

    Published on: 9 September 2016

  7. Research

    Attenuation of blood pressure in spontaneously hypertensive rats by acupuncture was associated with reduction oxidative stress and improvement from endothelial dysfunction

    Hypertension can be treated effectively by acupuncture; however, the association between acupuncture and endothelial function remains unknown. This study aimed to investigate the effects of acupuncture on endo...

    Sin Bond Leung, Hongwei Zhang, Chi Wai Lau and Zhi-Xiu Lin

    Chinese Medicine 2016 11:38

    Published on: 30 August 2016

  8. Research

    Indication of nerve growth factor binding components from herbal extracts by HerboChip: a platform for drug screening on a chip

    HerboChip is an array of different fractions deriving from herbal extracts. This study aimed to identify effective components from Chinese medicine (CM) that interact with nerve growth factor (NGF) as a target...

    Pinky Sum Chi Lee, Laura Minglu Zhang, Artemis Lu Yan, Kelly Yin Ching Lam, Tina Tingxia Dong, Huangquan Lin, Gallant Kar Lun Chan and Karl Wah Keung Tsim

    Chinese Medicine 2016 11:34

    Published on: 23 July 2016

  9. Research

    Influence of sulfur fumigation on glycoside profile in Platycodonis Radix (Jiegeng)

    Over recent decades, sulfur fumigation is becoming abused in processing some freshly harvested herbs used as both medicine and food, although it has been questioned whether sulfur fumigation will change the ef...

    Xiao-Qing Ma, Su-Mei Li, Chi Leung Chan, Tao Su, Wei-Dong Li, Hui Cao, Wang-Fun Fong and Zhi-Ling Yu

    Chinese Medicine 2016 11:32

    Published on: 6 July 2016

  10. Research

    Aikeqing decreases viral loads in SHIV89.6-infected Chinese rhesus macaques

    Aikeqing (AKQ) has been shown in clinical studies to improve quality of life of HIV/AIDS patients, but anti-HIV activity has not been determined. The SHIV-infected macaque is an import...

    Gao-Hong Zhang, Jian-Bao Han, Lin Zhu, Rong-Hua Luo, Xi-He Zhang, Xin Chen, Ying-Jie Hu, Lin-Chun Fu and Yong-Tang Zheng

    Chinese Medicine 2016 11:31

    Published on: 1 July 2016

  11. Research

    Antioxidant and physiological effects of Si-Wu-Tang on skin and liver: a randomized, double-blind, placebo-controlled clinical trial

    Si-Wu-Tang (SWT) is used to treat various gynecological disorders in Chinese medicine. This study investigated the antioxidant and physiological effects of SWT on the skin and liver in...

    Hui-Fang Chiu, Ying-Hua Wu, You-Cheng Shen, Shing-Jung Wang, Kamesh Venkatakrishnan and Chin-Kun Wang

    Chinese Medicine 2016 11:30

    Published on: 30 June 2016

  12. Review

    Chinese herbal medicine for constipation: zheng-based associations among herbs, formulae, proprietary medicines, and herb–drug interactions

    As current symptomatic treatments of constipation are still unsatisfactory, an increasing number of patients seek help from Chinese medicine (CM), particularly Chinese herbal medicine (CHM). This study aimed t...

    Linda L. D. Zhong, Guang Zheng, Li Da Ge, Cheng Yuan Lin, Tao Huang, Ling Zhao, Cheng Lu, Ai Ping Lu and Zhao Xiang Bian

    Chinese Medicine 2016 11:28

    Published on: 23 June 2016

  13. Research

    Gastrodia and Uncaria (tianma gouteng) water extract exerts antioxidative and antiapoptotic effects against cerebral ischemia in vitro and in vivo

    Gastrodia and Uncaria decoction (tianma gouteng yin) is commonly used in Chinese medicine to treat cerebral ischemia. The aim of this study was to investigate the neuroprotective effec...

    Jia Wen Xian, Angus Yiu-Ting Choi, Clara Bik-San Lau, Wing Nang Leung, Chun Fai Ng and Chun Wai Chan

    Chinese Medicine 2016 11:27

    Published on: 31 May 2016

  14. Research

    The variation in the major constituents of the dried rhizome of Ligusticum chuanxiong (Chuanxiong) after herbal processing

    Rhizoma Chuanxiong (RC; Chuanxiong), which is the dried rhizome of Ligusticum chuanxiong (Umbelliferae), is commonly used in Chinese medicine (CM) for improving blood circulation and dispersing blood stasis. RC i...

    Tao Yi, Jia-Yan Fang, Lin Zhu, Yi-Na Tang, Hong Ji, Ya-Zhou Zhang, Ju-Cheng Yu, Xiao-Jun Zhang, Zhi-Ling Yu, Zhong-Zhen Zhao and Hu-Biao Chen

    Chinese Medicine 2016 11:26

    Published on: 24 May 2016

  15. Research

    Antidiabetic and antioxidant effects of catalpol extracted from Rehmannia glutinosa (Di Huang) on rat diabetes induced by streptozotocin and high-fat, high-sugar feed

    Diabetes, associated with hyperlipidemia and oxidative stress, would lead to an increased production of reactive oxygen species. Rehmannia glutinosa (Di Huang) is widely used to nourish yin, invigorate the kidney

    Huifeng Zhu, Yuan Wang, Zhiqiang Liu, Jinghuan Wang, Dong Wan, Shan Feng, Xian Yang and Tao Wang

    Chinese Medicine 2016 11:25

    Published on: 11 May 2016

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