Articles

The development of an herbal material quality control strategy considering the effects of manufacturing processes

Quality by design (QbD) is an advanced drug quality control concept that has been gradually implemented in the optimization of manufacturing processes of Chinese medicines. However, the variation of Chinese me...

Authors: Jingjing Pan, Siyuan He, Jiayao Zheng, Jingyuan Shao, Ning Li, Yunqi Gong and Xingchu Gong

Identifying the active components of Baihe–Zhimu decoction that ameliorate depressive disease by an effective integrated strategy: a systemic pharmacokinetics study combined with classical depression model tests

Modern pharmacological studies have demonstrated that Baihe–Zhimu decoction (BZD) has antidepressant effects. However, the complex composition and lack of clear evaluation standards for BZD make it less likely...

Authors: Ming Zhong, Xiaoting Tian, Shuoji Chen, Mingcang Chen, Ziqiong Guo, Minna Zhang, Gongpu Zheng, Zhixiong Li, Zhangpeng Shi, Guanghui Wang, Honggang Gao, Fang Liu and Chenggang Huang

Preparation, optimization and in vitro–in vivo evaluation of Shunxin sustained release granules

Shunxinzufang decoction is tutors, empirical formula and has been used in Chinese patients of HFpEF for several years. The aim of this study was to make into sustained release granules and select the best form...

Authors: Yinghuan Dou, Xuefeng Li, Yanbin Shi, Jiaying Zhang, Yang Yuan, Mengru Zhou, Xiangxiang Wei and Xiaoying Zhang

Anti-inflammatory activities of Sigesbeckia glabrescens Makino: combined in vitro and in silico investigations

Sigesbeckia glabrescens Makino (SG) is one of the important plant origins of Sigesbeckiae herba and has been widely used for the treatment of chronic inflammatory diseases in China. However, the underlying anti-i...

Authors: Zhangfeng Zhong, Qianru Zhang, Hongxun Tao, Wei Sang, Liao Cui, Wenan Qiang, Wai San Cheang, Yuanjia Hu, Hua Yu and Yitao Wang

Traditional Chinese Medicine and regulatory roles on epithelial–mesenchymal transitions

Epithelial–mesenchymal transition (EMT) is a critical biological process allowing epithelial cells to de-differentiate into mesenchymal cells. Orchestrated signaling pathways cooperatively induce EMT and effec...

Authors: Jing Bai, Wee Chiew Kwok and Jean-Paul Thiery

The crude ethanol extract of Periplaneta americana L. stimulates wound healing in vitro & in vivo

Periplaneta americana L. is a Traditional Chinese Medicine that has been used in clinic treatment of various diseases for a long history. However, the therapeutic potential and the underlying mechanism of Peripla...

Authors: Long-Jian Li, Mao-Ze Wang, Tie-Jun Yuan, Xue-Han Xu, Haseeb Anwar Dad, Chui-Liang Yu, Jian Hou and Li-Hua Peng

Polyglycolic acid sutures embedded in abdominal acupoints for treatment of simple obesity in adults: a randomized control trial

Acupoint catgut embedding therapy characterized by acupoint, needle and catgut are superior to traditional acupuncture, due to exerting more comprehensive therapeutic efficacy. However, it is still deficient i...

Authors: Li-Shu Chen, Yue-Ying Li, Hao Chen, Bo-Wen Liu, Da-Wei Wang and Yong-Hua Zhao

Fecal medicines used in traditional medical system of China: a systematic review of their names, original species, traditional uses, and modern investigations

In China, the medical use of fecal matter (fresh fecal suspension or dry feces) can be dated back to the fourth century, approximately 1700 years ago. In long-term clinical practice, Chinese doctors have accum...

Authors: Huan Du, Ting-ting Kuang, Shuang Qiu, Tong Xu, Chen-Lei Gang Huan, Gang Fan and Yi Zhang

Metabolomics combined with network pharmacology exploration reveals the modulatory properties of Astragali Radix extract in the treatment of liver fibrosis

Astragali Radix (AR) is widely-used for improving liver fibrosis, but, the mechanism of action has not been systematically explained. This study aims to investigate the mechanism of AR intervention in liver fibro...

Authors: Dan Wang, Ruisheng Li, Shizhang Wei, Sijia Gao, Zhuo Xu, Honghong Liu, Ruilin Wang, Haotian Li, Huadan Cai, Jian Wang and Yanling Zhao

Dissection of the molecular targets and signaling pathways of Guzhi Zengsheng Zhitongwan based on the analysis of serum proteomics

Guzhi Zengsheng Zhitongwan (GZZSZTW) is an effective formula of traditional Chinese herbal medicine and has been widely applied in the treatment of joint diseases for many years. The aim of this study was to d...

Authors: Baojin Yao, Jia Liu, Duoduo Xu, Daian Pan, Mei Zhang, Daqing Zhao and Xiangyang Leng

Simultaneous UPLC–TQ-MS/MS determination of six active components in rat plasma: application in the pharmacokinetic study of Cyclocarya paliurus leaves

Cyclocarya paliurus (Batal.) Ijinskaja (CP) is a monotypic genus plant, also called sweet tea tree that belongs to the Juglandaceae family, which is mainly distributed in the subtropical highlands in China. Our p...

Authors: Zi-Wan Ning, Li-xiang Zhai, Jiao Peng, Ling Zhao, Tao Huang, Cheng-yuan Lin, Wei-hong Chen, Zhen Luo, Hai-tao Xiao and Zhao-xiang Bian

A network pharmacology-based study on the anti-hepatoma effect of Radix Salviae Miltiorrhizae

Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on human hepatocellular carci...

Authors: Yi Luo, Yu Feng, Lei Song, Gan-Qing He, Sha Li, Sha-Sha Bai, Yu-Jie Huang, Si-Ying Li, Mohammed M. Almutairi, Hong-Lian Shi, Qi Wang and Ming Hong

Efficacy of leflunomide combined with ligustrazine in the treatment of rheumatoid arthritis: prediction with network pharmacology and validation in a clinical trial

Leflunomide (LEF) is a first-line disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA). However, there are still a few nonresponders. It is logical to suggest that employing combinations ...

Authors: Chi Zhang, Daogang Guan, Miao Jiang, Chao Liang, Li Li, Ning Zhao, Qinglin Zha, Wandong Zhang, Cheng Lu, Ge Zhang, Jian Liu and Aiping Lu

A review on the immunomodulatory activity of Acanthopanax senticosus and its active components

Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, the dried root and rhizome or stem of Acanthopanax senticosus, is commonly known as Siberian ginseng or Ciwujia in Chinese. It is used all over the world as a...

Authors: Kit-Man Lau, Grace Gar-Lee Yue, Yuk-Yu Chan, Hin-Fai Kwok, Si Gao, Chun-Wai Wong and Clara Bik-San Lau

Botanicals as modulators of depression and mechanisms involved

Depression is the most disastrous mood disorder affecting the health of individuals. Conventional treatments with chemical compounds for depression have limitations, while herbal medicine has unique therapeuti...

Authors: Zhengrong Zhang, Taomei Deng, Manli Wu, Aisong Zhu and Guoqi Zhu

Novel drug delivery systems of Chinese medicine for the treatment of inflammatory bowel disease

Inflammatory bowel disease (IBD) is an idiopathic intestinal inflammatory disease that comprises ulcerative colitis (UC) and Crohn’s disease (CD). IBD involves the ileum, rectum, and colon, and common clinical...

Authors: Caifang Gao, Lijuan Liu, Yangyang Zhou, Zhaoxiang Bian, Shengpeng Wang and Yitao Wang

A tannin compound from Sanguisorba officinalis blocks Wnt/β-catenin signaling pathway and induces apoptosis of colorectal cancer cells

Sanguisorba officinalis, a popular Chinese herb, called DiYu, has been shown to inhibit the growth of many human cancer cell lines, including colorectal cancer cells. The aims of this study were to discover the a...

Authors: Wa Li, Chun-juan Yang, Li-qian Wang, Juan Wu, Cong Dai, Yue-mei Yuan, George Q. Li and Mei-cun Yao

Chemistry, pharmacology and analysis of Pseudostellaria heterophylla: a mini-review

Pseudostellaria heterophylla is one of the well-known traditional Chinese medicines and has been used in clinics for 100 years in China. The chemistry and pharmacology of P. heterophylla were reviewed to understa...

Authors: De-jun Hu, Farid Shakerian, Jing Zhao and Shao-Ping Li

Biofertilizers regulate the soil microbial community and enhance Panax ginseng yields

Panax ginseng is widely used as functional food and traditional Chinese medicine. To satisfy the market supply and medication safety, biofertilizers are used as agents to stimulate the growth and production of P....

Authors: Linlin Dong, Yong Li, Jiang Xu, Juan Yang, Guangfei Wei, Liang Shen, Wanlong Ding and Shilin Chen

The effects of bioactive components from the rhizome of Salvia miltiorrhiza (Danshen) on the characteristics of Alzheimer’s disease

Alzheimer’s disease (AD) is a common human neurodegenerative disease, which is characterized by the progressive loss of memory and the cognitive impairment. Since the etiology of AD is still unknown, it is ext...

Authors: Cheong-Meng Chong, Huanxing Su, Jin-Jian Lu and Yitao Wang

Metabolomics analysis of herb-partitioned moxibustion treatment on rats with diarrhea-predominant irritable bowel syndrome

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, which is commonly treated with antidiarrhoeal, antispasmodics, serotonergic agents or laxative agents. These treatments provide ...

Authors: Xianwei Lin, Xia Liu, Jingjing Xu, Kian-Kai Cheng, Jianan Cao, Tao Liu, Qiong Liu, Huan Zhong, Guiping Shen, Jiyang Dong and Xiaorong Chang

Review of traditional uses, botany, chemistry, pharmacology, pharmacokinetics, and toxicology of Radix Cyathulae

Cyathulae Radix (CR), also known as “Chuanniux” is a well-known traditional Chinese herbal medicine that has been used in China for thousands of years. The present work reviewed advances in traditional uses, o...

Authors: Yongliang Huang, Shanshan Wang, Li Liu, Wei Peng, Jiaolong Wang, Ying Song, Qianghua Yuan, Xing Yuan and Chunjie Wu

Combination of 15 lipid metabolites and motilin to diagnose spleen-deficiency FD

This study aims to assess clinical characteristics in FD with spleen deficiency syndrome and metabolic perturbations involved in FD progress. We combined metabolic biomarkers and clinical features into a bette...

Authors: Jiaqi Zhang, Xue Wang, Xiaoshuang Shi, Jingyi Xie, Min Zhang, Jinxin Ma, Fengyun Wang and Xudong Tang

Brain connectomic associations with traditional Chinese medicine diagnostic classification of major depressive disorder: a diffusion tensor imaging study

Major depressive disorder (MDD) is highly heterogeneous in pathogenesis and manifestations. Further classification may help characterize its heterogeneity. We previously have shown differential metabolomic pro...

Authors: Lan-Ying Liu, Xiao-Pei Xu, Li-Yuan Luo, Chun-Qing Zhu, Ya-Ping Li, Pei-Rong Wang, Yuan-Yuan Zhang, Chun-Yu Yang, Hong-Tao Hou, Yu-Lin Cao, Gang Wang, Edward S. Hui and Zhang-Jin Zhang

A pair of new enantiomers of xanthones from the stems and leaves of Cratoxylum cochinchinense

The simple and caged xanthones from Clusiaceae showed significant antineoplastic activity. This study aims to identify structural diverse xanthones and search for novel antitumor natural products from this fam...

Authors: Cuicui Jia, Chi Gong, Hong Chen, Jing Pu, Dahong Li, Zhanlin Li and Huiming Hua

Fabrication of paper-based enzyme immobilized microarray by 3D-printing technique for screening α-glucosidase inhibitors in mulberry leaves and lotus leaves

The discovery of bioactive compounds in traditional Chinese medicine (TCM) has become an important field in TCM modernization. Ligand fishing is a suitable method for discovery of bioactive compounds in comple...

Authors: Shangxin Guo, Xiaotong Lin, Yi Wang and Xingchu Gong

Immunomodulatory effects of a new whole ingredients extract from Astragalus: a combined evaluation on chemistry and pharmacology

Water extract (WAE) and ultrafine powder (UFP) are two types of commonly used supplements in preparing various pharmaceutical products and functional foods. However, the correlations of the chemical compositio...

Authors: Zhi Xin Li, Guan Ding Zhao, Wei Xiong, Ke Gang Linghu, Qiu Shuo Ma, Wai San Cheang, Hua Yu and Yitao Wang

Developing natural products as potential anti-biofilm agents

Biofilm is a natural form of bacterial growth ubiquitously in environmental niches. The biofilm formation results in increased resistance to negative environmental influences including resistance to antibiotic...

Authors: Lan Lu, Wei Hu, Zeru Tian, Dandan Yuan, Guojuan Yi, Yangyang Zhou, Qiang Cheng, Jie Zhu and Mingxing Li

Identifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells

Homeostasis is a crucial concept used to describe the condition of patients and the roles of herbs in traditional Chinese medicine. Qi-deficiency pattern is one of the conditions when loss of homeostasis and i...

Authors: Pin-Hao Ko, Chiung-Wei Huang, Hen-Hong Chang, Eric Y. Chuang, Mong-Hsun Tsai and Liang-Chuan Lai

Plastid genome and composition analysis of two medical ferns: Dryopteris crassirhizoma Nakai and Osmunda japonica Thunb.

Dryopteris crassirhizoma Nakai and Osmunda japonica Thunb. are ferns that are popularly used for medicine, as recorded by the Chinese pharmacopoeia, and are distributed in different regions of China. However, O. ...

Authors: Liang Xu, Yanping Xing, Bing Wang, Chunsheng Liu, Wenquan Wang and Tingguo Kang

Application of metabolomics in viral pneumonia treatment with traditional Chinese medicine

Nowadays, traditional Chinese medicines (TCMs) have been reported to provide reliable therapies for viral pneumonia, but the therapeutic mechanism remains unknown. As a systemic approach, metabolomics provides...

Authors: Lili Lin, Hua Yan, Jiabin Chen, Huihui Xie, Linxiu Peng, Tong Xie, Xia Zhao, Shouchuan Wang and Jinjun Shan

Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation

Shikonin (SKN), a naphthoquinone compound, is isolated from Chinese herbal medicine Lithospermum root and has been studied as an anticancer drug candidate in human tumor models. This study is designed to investig...

Authors: Zhu Wang, Jianhua Yin, Mingxing Li, Jing Shen, Zhangang Xiao, Yueshui Zhao, Chengliang Huang, Hanyu Zhang, Zhuo Zhang, Chi Hin Cho and Xu Wu

Rapid discovery of chemical constituents and absorbed components in rat serum after oral administration of Fuzi-Lizhong pill based on high-throughput HPLC-Q-TOF/MS analysis

Fuzi-Lizhong pill (FZLZP), which was first recorded in the Classic–“Taiping Huimin Heji Ju Fang” of the Song Dynasty, has been widely used to treat gastrointestinal disease in clinic for thousands of years in ...

Authors: Zhen Zhang, Maoyuan Jiang, Xinyi Wei, Jinfeng Shi, Zhao Geng, Shasha Yang, Chaomei Fu and Li Guo

High content screening for drug discovery from traditional Chinese medicine

Traditional Chinese medicine (TCM) represents the crystallization of Chinese wisdom and civilization. It has been valued as the renewable source for the discovery of novel drugs, owing to its long-term proved ...

Authors: Jing Wang, Ming-Yue Wu, Jie-Qiong Tan, Min Li and Jia-Hong Lu

A new GIS model for ecologically suitable distributions of medicinal plants

The endangered rate of medicinal plant exceeds that of endangered plant species. However, blindly introducing medicinal plants in regions without comprehensively considering the involved environmental factors ...

Authors: Jie Wu, Xiwen Li, Linfang Huang, Xiangxiao Meng, Haoyu Hu, Lu Luo and Shilin Chen

Baduanjin exerts anti-diabetic and anti-depression effects by regulating the expression of mRNA, lncRNA, and circRNA

Baduanjin, a traditional Chinese exercise therapy, has been widely used in China to treat type 2 diabetes (T2DM) with depression (DD). However, the underlying mechanism of Baduanjin in anti-DD is unclear. This...

Authors: Tian An, Zhong-Chen He, Xin-Qing Zhang, Jun Li, Ai-Ling Chen, Fang Tan, Hong-Dong Chen, Bo-Han Lv, Juan Lian, Si-Hua Gao and Guang-Jian Jiang

Chinese herb pair Paeoniae Radix Alba and Atractylodis Macrocephalae Rhizoma suppresses LPS-induced inflammatory response through inhibiting MAPK and NF-κB pathway

The combination of Radix Paeoniae Alba (RPA) and Rhizoma Atractylodis Macrocephalae (RAM) has long been used as a classic herb pair for the treatment of gynecologic and gastrointestinal diseases, but the under...

Authors: Yangyang Zhou, Hongxun Tao, Anqi Wang, Zhangfeng Zhong, Xu Wu, Mei Wang, Zhaoxiang Bian, Shengpeng Wang and Yitao Wang

Differential proteomics for studying action mechanisms of traditional Chinese medicines

Differential proteomics, which has been widely used in studying of traditional Chinese medicines (TCMs) during the past 10 years, is a powerful tool to visualize differentially expressed proteins and analyzes ...

Authors: Yi-Yao Yang, Feng-Qing Yang and Jian-Li Gao

Systems biology approaches in the study of Chinese herbal formulae

Systems biology is an academic field that attempts to integrate different levels of information to understand how biological systems function. It is the study of the composition of all components of a biologic...

Authors: Fei-Fei Cai, Wen-Jun Zhou, Rong Wu and Shi-Bing Su

An innovative anti-cancer Chinese herbal formula exhibited multi-targeted efficacies in metastatic breast cancer mouse model

The incidence and mortality of cancer metastasis is high worldwide. Despite of the chemotherapeutic agents, many cancer patients still take traditional Chinese herbal prescriptions as adjuvant treatments. Howe...

Authors: Grace Gar-Lee Yue, Julia Kin-Ming Lee, Ben Chung-Lap Chan, Hin-Fai Kwok, Sandy Wan-Heng Hoi, Daniel Man-Yuen Sze, Kwok-Pui Fung, Ping-Chung Leung and Clara Bik-San Lau

Gut microbiota was modulated by moxibustion stimulation in rats with irritable bowel syndrome

The pathogenesis of irritable bowel syndrome (IBS) is closely related to intestinal dysbacteriosis and can be controlled by moxibustion treatment. However, the mechanism underlying the therapeutic value of mox...

Authors: Xiaomei Wang, Qin Qi, Yuanyuan Wang, Huangan Wu, Xiaoming Jin, Huan Yao, Duiyin Jin, Yanan Liu and Cun Wang

Cardiac function evaluation for a novel one-step detoxification product of Aconiti Lateralis Radix Praeparata

Aconiti Lateralis Radix Praeparata has been used as the first cardiac drug over a 1000 years in Asian countries. Although most detoxification products are confirmed to be safe, the effect is not potent as desired...

Authors: Ya-nan He, Ding-kun Zhang, Jun-zhi Lin, Xue Han, Ya-ming Zhang, Hai-zhu Zhang, Jin Pei, Ming Yang and Jia-bo Wang

Metabonomic study of the protective effect of Fukeqianjin formula on multi-pathogen induced pelvic inflammatory disease in rats

Fukeqianjin formula has been effectively used in the treatment of pelvic inflammatory disease (PID) and the related complications in clinic. Although there have been some studies about the underlying mechanism...

Authors: Yan Zhang, Wei Li, Liang Zou, Yun Gong, Peng Zhang, Shasha Xing and Hang Yang

Application of metabolomics in toxicity evaluation of traditional Chinese medicines

Traditional Chinese medicines (TCM) have a long history of use because of its potential complementary therapy and fewer adverse effects. However, the toxicity and safety issues of TCM have drawn considerable a...

Authors: Li Duan, Long Guo, Lei Wang, Qiang Yin, Chen-Meng Zhang, Yu-Guang Zheng and E.-Hu Liu

Pharmacological effects of medicinal components of Atractylodes lancea (Thunb.) DC.

Atractylodes lancea Thunb. DC. (AL) has a long history as one of the important herbs used in East Asia. This review is on the purpose of providing a comprehensive summary of the pharmacological effects of AL and ...

Authors: Xie Jun, Peng Fu, Yu Lei and Peng Cheng

Abstracts from the 4th Global Chinese Symposium and the 8th Symposium for cross-straits, Hong Kong and Macao on free radical biology and medicine

Authors:

Abstracts from The International Conference on Medicinal Plants and Bioeconomy & the 1st Sino-CPLP Symposium on Natural Products and Biodiversity Resources

Authors:

Predicting the potential global distribution of diosgenin-contained Dioscorea species

Diosgenin, mainly extracted from wild diosgenin-contained Dioscorea species, is a well-known starting material of steroidal and contraceptive drugs. However, due to large market demand and increasingly ecological...

Authors: Liang Shen, Jiang Xu, Lu Luo, Haoyu Hu, Xiangxiao Meng, Xiwen Li and Shilin Chen

A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide

Modern studies have shown that adaptogens can non-specifically enhance the resistance of human body under a wide range of external stress conditions with a multi-targeted and multi-channel network-like manner,...

Authors: Lian-ying Liao, Yi-fan He, Li Li, Hong Meng, Yin-mao Dong, Fan Yi and Pei-gen Xiao

Comparing the antidiabetic effects and chemical profiles of raw and fermented Chinese Ge-Gen-Qin-Lian decoction by integrating untargeted metabolomics and targeted analysis

Microbial fermentation has been widely applied in traditional Chinese medicine (TCM) for thousands of years in China. Various beneficial effects of fermentation for applications in TCM or herbals have been rep...

Authors: Yan Yan, Chenhui Du, Zhenyu Li, Min Zhang, Jin Li, Jinping Jia, Aiping Li, Xuemei Qin and Qiang Song