Melanoma is a leading cause of cancer death worldwide, and SMI-4a and G-Rh2 exert anti-tumor activity in multiple cancer. However, SMI-4a as well as a synergistic relationship between SMI-4a and G-Rh2 in anti-...
Authors: Da-lun Lv, Lei Chen, Wei Ding, Wei Zhang, He–li Wang, Shuai Wang and Wen-bei Liu
Amomum compactum is one of the basic species of the traditional herbal medicine amomi fructus rotundus, with great pharmacology effect. The system position of A. compactum is not clear yet, and the introduction o...
Authors: Ming-li Wu, Qing Li, Jiang Xu and Xi-wen Li
Through reviewing the current international market for traditional Chinese medicine (TCM), this paper identified the internationalization challenges for TCM, including unclear therapeutic material basis and me...
Authors: Annie Xianghong Lin, Ging Chan, Yuanjia Hu, Defang Ouyang, Carolina Oi Lam Ung, Luwen Shi and Hao Hu
Rhizoma Paridis (Chonglou) is a commonly used and precious traditional Chinese medicine. Paris polyphylla Smith var. yunnanensis (Franch.) Hand. -Mazz. and Paris polyphylla Smith var. chinensis (Franch.) Hara are...
Authors: Bao-Zhong Duan, Ya-Ping Wang, Hai-Lan Fang, Chao Xiong, Xi-Wen Li, Ping Wang and Shi-Lin Chen
Functional polysaccharides can be derived from plants (including herbs), animals and microorganisms. They have been widely used in a broad of biomedical applications, such as immunoregulatory agents or drug de...
Authors: Qiu Li, Yiming Niu, Panfei Xing and Chunming Wang
To determine the effect of Shuganyin decoction (SGD) on the intestinal barrier function in an irritable bowel syndrome (IBS) rat model induced by water-avoidance stress.
Authors: Lu Lu, Liang Yan, Jianye Yuan, Qing Ye and Jiang Lin
Traditional Chinese medicine (TCM) is currently the best-preserved and most influential traditional medical system with the largest number of users worldwide. In recent years, the trend of TCM adoption has inc...
Authors: Haitao Tang, Wenlong Huang, Jimei Ma and Li Liu
Processing (Paozhi) represents a unique Chinese pharmaceutic technique to facilitate the use of Chinese herbal medicines (CHMs) for a specific clinical need in the guidance of Traditional Chinese Medicine (TCM) t...
Authors: Xu Wu, Shengpeng Wang, Junrong Lu, Yong Jing, Mingxing Li, Jiliang Cao, Baolin Bian and Changjiang Hu
Compatibility with Panax notoginseng (PN) reduced the plasma concentration of triptolide and delayed the Tmax of Tripterygium wilfordii (TW), the sovereign medicine of Qing-Luo Tong-Bi decoction, which hinted the...
Zhibai Dihuang Granule (ZDG) is a traditional Chinese medicine which has been used to treat Yin-deficiency-heat (YDH) syndrome for thousands of years in China. However, little work has been conducted to explor...
Authors: Chang-Ming Liu, Jing Chen, Su Yang, Ting-Ting Jiang, Zhong-Liang Chen, Hui-Hui Tu, Lian-Gen Mao, Yu-Ting Hu, Lin Gan, Zhong-Jie Li and Ji-Cheng Li
Rhubarb is one of the most ancient, commonly used and important herbs in Chinese medicine. The modern researches of rhubarb clarified the efficacies, ingredients and mechanisms in a more scientific and rigorou...
Authors: Yu-Jie Cao, Zong-Jin Pu, Yu-Ping Tang, Juan Shen, Yan-Yan Chen, An Kang, Gui-Sheng Zhou and Jin-Ao Duan
Dysfunctional metabolisms are contributed to LPS/GALN-induced hepatitis. However, whether Hedyotis diffusa (HD) employs metabolic strategies against hepatitis is unknown.
Authors: Min Dai, Fenglin Wang, Zengcheng Zou, Gemin Xiao, Hongjie Chen and Hongzhi Yang
Nowadays, Radix Polygoni Multiflori (RPM, Heshouwu in Chinese) from different geographical origins were used in clinic. In order to characterize the chemical profiles of different geographical origins of RPM s...
Authors: Jin-Fa Tang, Wei-Xia Li, Fan Zhang, Yu-Hui Li, Ying-Jie Cao, Ya Zhao, Xue-Lin Li and Zhi-Jie Ma
The non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. In NSCLC, the oncogenic AKT-mTOR, ERK and STAT3 pathways are commonly dysregulated and have emerged as attractive targets ...
Authors: I-Chun Lai, Gi-Ming Lai, Jyh-Ming Chow, Hsin-Lun Lee, Chuan-Feng Yeh, Chi-Han Li, Jiann-Long Yan, Shuang-En Chuang, Jacqueline Whang-Peng, Kuan-Jen Bai and Chih-Jung Yao
Wound ointment (WO), a kind of Chinese medicine, can significantly promote fracture healing. The study aimed at analyzing the chemical composition and the effects of WO on fracture of rabbits and tried to expl...
Authors: Zhixue Ou, Qi Cheng, Yueping Chen, Tao Chen, Xiangbin Rong, Feipan Long, Xiaoyun Zhang, Qinghua Liang and Zhe Feng
Penthorum chinense Pursh (Penthoraceae, PCP), a well-known Miao ethnomedicine, has been traditionally used to treat several liver-related diseases, such as jaundice and viral hepatitis...
Authors: Meng Wang, Xiao-Jiao Zhang, Ruibing Feng, Yun Jiang, Da-Yong Zhang, Chengwei He, Peng Li and Jian-Bo Wan
Stroke is the second most common cause of death and may result in various disabilities; thus, identification of neuroprotective therapeutic agents is important. Peucedani Radix (PR), the root of Angelica decursiv...
Authors: So-Youn Jung, Kyoung-Min Kim, Suin Cho, Sehyun Lim, Chiyeon Lim and Young Kyun Kim
The dried root of Salvia miltiorrhiza, Salviae miltiorrhizae Radix (SR), is one of the most popular medicinal herbs in Asian countries such as China and Korea. In Asian traditional medicine, SR is considered to h...
Authors: Chiyeon Lim, Sehyun Lim, Byoungho Lee, Buyeo Kim and Suin Cho
Since the incidence of cancer has been on the rise due to increasing exposure to various carcinogenic factors in recent years, cancer has gradually become the first killer to the health of human beings. A grow...
Authors: Yanan Zhao, Ailin Yang, Pengfei Tu and Zhongdong Hu
Valuable scientific results on biomedicine are very rich, but they are widely scattered in the literature. Topic modeling enables researchers to discover themes from an unstructured collection of documents wit...
Authors: Qian Chen, Ni Ai, Jie Liao, Xin Shao, Yufeng Liu and Xiaohui Fan
The vast majority of stroke burden is attributable to its modifiable risk factors. This paper aimed to systematically summarise the evidence of Chinese herbal medicine (CHM) interventions on stroke modifiable ...
Authors: Wenbo Peng, Romy Lauche, Caleb Ferguson, Jane Frawley, Jon Adams and David Sibbritt
Danggui Buxue Tang (DBT), a phytoestrogen-enriched Chinese herbal formula, serves as dietary supplement in stimulating the “Blood” functions of menopausal women. In traditional Chinese medicine (TCM) theory, “Blo...
Authors: Amy G. W. Gong, Huai Y. Wang, Tina T. X. Dong, Karl W. K. Tsim and Y. Z. Zheng
QiXueHe Capsule (QXHC) is a Chinese patent drug that is extensively used for the treatment of menstrual disorders. However, its underlying pharmacological mechanisms have not been fully elucidated.
Authors: Yanqiong Zhang, Xia Mao, Jing Su, Ya Geng, Rui Guo, Shihuan Tang, Junfang Li, Xuefeng Xiao, Haiyu Xu and Hongjun Yang
The objective of this study was to examine, in individuals with lateral epicondylalgia (LE), the acute time course of acupuncture-induced hypoalgesia and change in pain-free grip strength (PFGS).
Both cupping therapy and acupuncture have been used in China for a long time, and their target indications are pain-related conditions. There is no systematic review comparing the effectiveness of these two th...
Authors: Ya-Jing Zhang, Hui-Juan Cao, Xin-Lin Li, Xiao-Ying Yang, Bao-Yong Lai, Guo-Yang Yang and Jian-Ping Liu
In traditional Chinese medicine (TCM) theory, pathogenic heat and toxins, which are akin to the inflammatory factors, are the causes of cancer and could promote its virulent development. Therefore, heat-cleari...
As an empirical medical system independent of conventional Western medicine (CWM), over thousands of years, traditional Chinese medicine (TCM) has established its own unique method of diagnosis and treatment. ...
Authors: Enliang Yan, Jialin Song, Chaonan Liu and Wenxue Hong
American ginseng (Panax quinquefolius L.) is renowned worldwide for its eutherapeutic effects. The replantation of American ginseng usually fails due to problems associated with continuous cropping. An imbalance ...
Authors: Linlin Dong, Jiang Xu, Lianjuan Zhang, Juan Yang, Baosheng Liao, Xiwen Li and Shilin Chen
This retrospective cross-sectional study aimed to investigate the relationship between Chinese medicine (CM) dietary patterns (hot, neutral, and cold) and the incidence of breast cancer among Chinese women in Hon...
Authors: Xiao Zheng, Jianping Chen, Ting Xie, Zhiyu Xia, Wings Tjing Yung Loo, Lixing Lao, JieShu You, Jie Yang, Kamchuen Tsui, Feizhi Mo and Fei Gao
Analysis of related substances in pharmaceutical chemicals and multi-components in traditional Chinese medicines needs bulk of reference substances to identify the chromatographic peaks accurately. But the ref...
Authors: Lei Sun, Hong-yu Jin, Run-tao Tian, Ming-juan Wang, Li-na Liu, Liu-ping Ye, Tian-tian Zuo and Shuang-cheng Ma
A few bioactivities of constituents from Gynostemma laxum, which has been collected in Vietnam, have been
reported until now. There is no report about the effects of constituents from G. laxum although the nucle...
Authors: Ji Yeon Seo, Sang Kyum Kim, Phi Hung Nguyen, Ju Yong Lee, Pham Ha Thanh Tung, Sang Hyun Sung and Won Keun Oh
Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena asphodeloides Bunge, and Coptis chinensis Franch. F...
Authors: Jin-Ni Hong, Wei-Wei Li, Lin-Lin Wang, Hao Guo, Yong Jiang, Yun-Jia Gao, Peng-Fei Tu and Xue-Mei Wang
The content of medicinal bioactive constituents in huangqi is affected by plant age. In this study, we devised a quick and convenient method for determining the age of huangqi, which was cultivated in Hunyuan Cou...
Authors: Hua-Sheng Peng, Jun Wang, He-Ting Zhang, Hai-Yan Duan, Xiao-Mei Xie, Ling Zhang, Ming-En Cheng and Dai-yin Peng
Herbal quality is strongly influenced by harvest time. It is therefore one of crucial factors that should be well respected by herbal producers when optimizing cultivation techniques, so that to obtain herbal ...
Authors: Kai Tong, Zhao-ling Li, Xu Sun, Shen Yan, Mei-jie Jiang, Meng-sheng Deng, Ji Chen, Jing-wei Li and Meng-liang Tian
Bushen Tianjing Recipe (BTR) is a traditional Chinese herbal medicine that has been prescribed for premature ovarian failure (POF) for decades in China. Nevertheless, little is known regarding its underlying m...
Herbochip® technology is a high throughput drug screening platform in a reverse screening manner, in which potential chemical leads in herbal extracts are immobilized and drug target proteins can be used as probe...
Authors: Iao-Fai Lam, Min Huang, Margaret Dah-Tysr Chang, Pei-Wun Yao, Yu-Ting Chou, Sim-Kun Ng, Ying-Lin Tsai, Yu-Chang Lin, Yun-feng Zhang, Xiao-yuan Yang and Yiu-Kay Lai
Glossogyne tenuifolia (GT) (Hsiang-ju) is a Chinese herbal medicine previously exhibited an anti-inflammatory activity. This study aimed to investigate the effect of GT ethanol extract...
Authors: Jer-Yiing Houng, Tzong-Shyuan Tai, Shu-Ching Hsu, Hsia-Fen Hsu, Tzann-Shun Hwang, Chih-Jiun Lin and Li-Wen Fang
The Kampo medicine bofutsushosan (BTS; Pulvis ledebouriellae compositae; Fang Feng Tong Sheng San) has been used as an anti-obesity treatment in overweight patients. In this study, we assessed the underlying phys...
Combinations of the traditional Chinese and Western medicines have been used to treat numerous diseases throughout the world, and there is a growing body of evidence showing that some of the herbs used in trad...
Authors: Ling-Wei Hsu, Wei-Cheng Shiao, Nen-Chung Chang, Meng-Che Yu, Ting-Lin Yen, Philip Aloysius Thomas, Thanasekaran Jayakumar and Joen-Rong Sheu
Citri Exocarpium Rubrum (CER), which is known as Juhong in Chinese, is the dried exocarp of Citrus reticulata Blanco and its cultivars (Fam. Rutaceae) and is currently used in Chinese medicine to protect the stom...
Authors: Yang Zhao, Chun-Pin Kao, Chi-Ren Liao, Kun-Chang Wu, Xin Zhou, Yu-Ling Ho and Yuan-Shiun Chang
Postoperative gastrointestinal dysfunction (PGD) is a common complication following laparotomy under general anesthesia (GA). Abdominal distension occurs in 8–28% of surgeries within 24 h postoperatively. The ...
Authors: Meng-yue Liu, Cheng-wei Wang, Zhou-peng Wu and Ning Li
Anti-cholinergic agents may be used to inhibit duodenal peristalsis, but they may have adverse effects. Shakuyakukanzoto (Shao Yao Gan Cao Tang) has an anti-spasmodic effect and has been used before for oesophago...
Authors: Haruka Fujinami, Shinya Kajiura, Jun Nishikawa, Takayuki Ando and Toshiro Sugiyama
Lycii Cortex (LyC), composed of Lycium chinense and Lycium barbarum cortex and having the Chinese name Digupi, is used to treat chronic diseases like cough, hypertension, and diabetes in Eastern Asia. However, ch...
The dried parts of medicinal herbs are susceptible to the infection of fungi during pre- or post-harvest procedure. This study aimed to investigate the presence of fungi and their metabolites mycotoxins on the...
Identification of bioactive standard chemicals is a major challenge in the study of the Chinese medicinal formula. In particular, the chemical components may interact differently depending on the preparative m...
Authors: H. P. Cheung, S. W. Wang, T. B. Ng, Y. B. Zhang, L. X. Lao, Z. J. Zhang, Y. Tong, F. W. S. Chung and S. C. W. Sze
Isodon lophanthoides, I. lophanthoides var. graciliflorus and I. serra are the three botanical sources of Xihuangcao, which are often used indiscriminately in herbal products. The aim ...
Authors: Lai Lai Wong, Zhitao Liang, Hubiao Chen and Zhongzhen Zhao
Acupuncture has been widely used as a treatment for alcohol dependence. An updated and rigorously conducted systematic review is needed to establish the extent and quality of the evidence on the effectiveness ...
Authors: Charlotte Southern, Charlie Lloyd, Jianping Liu, Congcong Wang, Tingting Zhang, Martin Bland and Hugh MacPherson
Modified Erxian decoction (MEXD), i.e., Erxian decoction (EXD) with Fructus Schisandrae chinensis (Wu Wei Zi) added, has been used to alleviate menopausal symptoms. This study aimed to investigate the effects of...
Authors: Shi Wei Wang, Fei Hua Wu, Yan Bo Zhang, Liang Zhang, Jing Su, Hei Kei Wong, Ai Hua Liu, Ho Pan Cheung, Tzi Bun Ng, Yao Tong and Stephen Cho Wing Sze
