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  1. Content type: Research

    Bromelain, which is a cysteine endopeptidase commonly found in pineapple stems, has been investigated as a potential anti-cancer agent for the treatment of breast cancer. However, information pertaining to the...

    Authors: Ahmad Zaim Mat Pauzi, Swee Keong Yeap, Nadiah Abu, Kian Lam Lim, Abdul Rahman Omar, Suraini Abdul Aziz, Adam Leow Thean Chow, Tamilselvan Subramani, Soon Guan Tan and Noorjahan Banu Alitheen

    Citation: Chinese Medicine 2016 11:46

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  2. Content type: Research

    Trans-ferulic (FA) acid exhibits antioxidant effects in vitro. However, the underlying mechanism of trans-FA activity in cellular physiology, especially cancer physiology, remains larg...

    Authors: Yao Fong, Chia-Chun Tang, Huei-Ting Hu, Hsin-Yu Fang, Bing-Hung Chen, Chang-Yi Wu, Shyng-Shiou Yuan, Hui-Min David Wang, Yen-Chun Chen, Yen-Ni Teng and Chien-Chih Chiu

    Citation: Chinese Medicine 2016 11:45

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  3. Content type: Research

    Tianma-Gouteng-Yin (TGY), which is common Chinese medicine formulation consisting of 11 different herbs and being used in China for the treatment of Parkinson’s disease, inflammatory c...

    Authors: Ying-Yu Huang, Liang-Feng Liu, Rui-Qi Yue, Jun Xu, Alan Ho, Min Li and Quan-Bin Han

    Citation: Chinese Medicine 2016 11:44

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  4. Content type: Research

    Acori Tatarinowii Rhizoma (ATR; rhizome of Acorus tatarinowii Schott) (Shi Chang Pu) is widely used in Chinese medicine (CM) to resuscitate, calm the mind, resolve shi (dampness) and harmonize the wei (stomach). ...

    Authors: Kelly Yin-Ching Lam, Chuen-Fai Ku, Huai-You Wang, Gallant Kar-Lun Chan, Ping Yao, Huang-Quan Lin, Tina Ting-Xia Dong, Hong-Jie Zhang and Karl Wah-Keung Tsim

    Citation: Chinese Medicine 2016 11:41

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  5. Content type: Research

    Yunu-Jian (YJ) is a Chinese medicine (CM) heat purging formula, which is used to reduce wei huo (stomach-heat, SH) and enrich shen yin (kidney-yin, KY). This formula is also commonly u...

    Authors: Kwan-Yat Zee, Pui Sze Chan, Johnson Chun Sing Ho, Stanley Man Lung Lai, Esmonde Francis Corbet and Wai Keung Leung

    Citation: Chinese Medicine 2016 11:40

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  6. Content type: Research

    Retinal ischemia is a retinal disorder related to retinal vascular occlusion, glaucoma, diabetic retinopathy and age-related macular degeneration. The study aimed to evaluate the protective effects and underly...

    Authors: Ji-Min Cheng, Xiao-Qian Liu, Jorn-Hon Liu, Wynn Hwai-Tzong Pan, Xiu-Mei Zhang, Lei Hu and Hsiao-Ming Chao

    Citation: Chinese Medicine 2016 11:39

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  7. Content type: Research

    Hypertension can be treated effectively by acupuncture; however, the association between acupuncture and endothelial function remains unknown. This study aimed to investigate the effects of acupuncture on endo...

    Authors: Sin Bond Leung, Hongwei Zhang, Chi Wai Lau and Zhi-Xiu Lin

    Citation: Chinese Medicine 2016 11:38

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  8. Content type: Review

    Medicinal plants are globally valuable sources of herbal products, and they are disappearing at a high speed. This article reviews global trends, developments and prospects for the strategies and methodologies...

    Authors: Shi-Lin Chen, Hua Yu, Hong-Mei Luo, Qiong Wu, Chun-Fang Li and André Steinmetz

    Citation: Chinese Medicine 2016 11:37

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  9. Content type: Research

    The concept of syndromes (zhengs) is unique to Chinese medicine (CM) and difficult to measure. Expert consensus is used as a gold standard to identify zhengs and evaluate the accuracy of existing diagnostic scale...

    Authors: Xiao Nan Wang, Vanessa Zhou, Qiang Liu, Ying Gao and Xiao-Hua Zhou

    Citation: Chinese Medicine 2016 11:35

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  10. Content type: Research

    HerboChip is an array of different fractions deriving from herbal extracts. This study aimed to identify effective components from Chinese medicine (CM) that interact with nerve growth factor (NGF) as a target...

    Authors: Pinky Sum Chi Lee, Laura Minglu Zhang, Artemis Lu Yan, Kelly Yin Ching Lam, Tina Tingxia Dong, Huangquan Lin, Gallant Kar Lun Chan and Karl Wah Keung Tsim

    Citation: Chinese Medicine 2016 11:34

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  11. Content type: Research

    Over recent decades, sulfur fumigation is becoming abused in processing some freshly harvested herbs used as both medicine and food, although it has been questioned whether sulfur fumigation will change the ef...

    Authors: Xiao-Qing Ma, Su-Mei Li, Chi Leung Chan, Tao Su, Wei-Dong Li, Hui Cao, Wang-Fun Fong and Zhi-Ling Yu

    Citation: Chinese Medicine 2016 11:32

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  12. Content type: Research

    The quality of the materials used in Chinese medicine (CM) is generally assessed based on an analysis of their chemical components (e.g., chromatographic fingerprint analysis). However, there is a growing inte...

    Authors: Xicheng He, Tao Yi, Yina Tang, Jun Xu, Jianye Zhang, Yazhou Zhang, Lisha Dong and Hubiao Chen

    Citation: Chinese Medicine 2016 11:33

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  13. Content type: Research

    Aikeqing (AKQ) has been shown in clinical studies to improve quality of life of HIV/AIDS patients, but anti-HIV activity has not been determined. The SHIV-infected macaque is an import...

    Authors: Gao-Hong Zhang, Jian-Bao Han, Lin Zhu, Rong-Hua Luo, Xi-He Zhang, Xin Chen, Ying-Jie Hu, Lin-Chun Fu and Yong-Tang Zheng

    Citation: Chinese Medicine 2016 11:31

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  14. Content type: Research

    Si-Wu-Tang (SWT) is used to treat various gynecological disorders in Chinese medicine. This study investigated the antioxidant and physiological effects of SWT on the skin and liver in...

    Authors: Hui-Fang Chiu, Ying-Hua Wu, You-Cheng Shen, Shing-Jung Wang, Kamesh Venkatakrishnan and Chin-Kun Wang

    Citation: Chinese Medicine 2016 11:30

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  15. Content type: Research

    This study aims to determine the synergistic effects of the chemotherapeutic drug melphalan and the phytoconstituents extracted from Pinus kesiya Royle ex Gordon (Simaosong) in human cancer cells.

    Authors: Natthida Weerapreeyakul, Sasipawan Machana and Sahapat Barusrux

    Citation: Chinese Medicine 2016 11:29

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  16. Content type: Review

    As current symptomatic treatments of constipation are still unsatisfactory, an increasing number of patients seek help from Chinese medicine (CM), particularly Chinese herbal medicine (CHM). This study aimed t...

    Authors: Linda L. D. Zhong, Guang Zheng, Li Da Ge, Cheng Yuan Lin, Tao Huang, Ling Zhao, Cheng Lu, Ai Ping Lu and Zhao Xiang Bian

    Citation: Chinese Medicine 2016 11:28

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  17. Content type: Research

    Gastrodia and Uncaria decoction (tianma gouteng yin) is commonly used in Chinese medicine to treat cerebral ischemia. The aim of this study was to investigate the neuroprotective effec...

    Authors: Jia Wen Xian, Angus Yiu-Ting Choi, Clara Bik-San Lau, Wing Nang Leung, Chun Fai Ng and Chun Wai Chan

    Citation: Chinese Medicine 2016 11:27

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  18. Content type: Research

    Rhizoma Chuanxiong (RC; Chuanxiong), which is the dried rhizome of Ligusticum chuanxiong (Umbelliferae), is commonly used in Chinese medicine (CM) for improving blood circulation and dispersing blood stasis. RC i...

    Authors: Tao Yi, Jia-Yan Fang, Lin Zhu, Yi-Na Tang, Hong Ji, Ya-Zhou Zhang, Ju-Cheng Yu, Xiao-Jun Zhang, Zhi-Ling Yu, Zhong-Zhen Zhao and Hu-Biao Chen

    Citation: Chinese Medicine 2016 11:26

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  19. Content type: Research

    Diabetes, associated with hyperlipidemia and oxidative stress, would lead to an increased production of reactive oxygen species. Rehmannia glutinosa (Di Huang) is widely used to nourish yin, invigorate the kidney

    Authors: Huifeng Zhu, Yuan Wang, Zhiqiang Liu, Jinghuan Wang, Dong Wan, Shan Feng, Xian Yang and Tao Wang

    Citation: Chinese Medicine 2016 11:25

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  20. Content type: Research

    Ganoderma lucidum (Lingzhi; LZ) and San-Miao-San (SMS) are Chinese medicines (CMs) used to treat inflammatory ailments and numbing syndrome/arthralgia syndrome (Bi Zheng), respectively...

    Authors: Zhe Cai, Chun Kwok Wong, Jie Dong, Delong Jiao, Man Chu, Ping Chung Leung, Clara Bik San Lau, Ching Po Lau, Lai Shan Tam and Christopher Wai Kei Lam

    Citation: Chinese Medicine 2016 11:23

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  21. Content type: Research

    Loki zupa (Luooukezupa) decoction, consisting of the roots of Hyssopuscuspidatus Boriss (Shenxiangcao) and Irishalophila Pall root (Yuanweigen), is commonly used in Uygur medicine to t...

    Authors: Ying Wei, Muhammadjan Abduwaki, Mihui Li, Qingli Luo, Jing Sun, Yubao Lv, Mammat Nurahmat and Jingcheng Dong

    Citation: Chinese Medicine 2016 11:22

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  22. Content type: Research

    Chinese medicinal herbs may use more than one species of Curcumae Radix (Yujin) is the tuberous roots of Curcumae wenyujin, C. kwangsiensis, C. phaeocaulis and C. longa. This study aimed to characterize the chemi...

    Authors: Fang Liu, Xu Bai, Feng-Qing Yang, Xiao-Jing Zhang, Yuanjia Hu, Peng Li and Jian-Bo Wan

    Citation: Chinese Medicine 2016 11:21

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  23. Content type: Research

    Herb-partitioned moxibustion (HPM) at Tianshu (ST25) and Qihai (RN6) has been used to treat Crohn’s disease (CD). Injury to intestinal epithelial tight junctions (TJs) is the leading cause of CD onset with under ...

    Authors: Rong Ji, Anqi Wang, Haixia Shang, Liu Chen, Chunhui Bao, Luyi Wu, Huangan Wu and Yin Shi

    Citation: Chinese Medicine 2016 11:20

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  24. Content type: Research

    Herbal plants are a preferred source of anticancer agents. This study aims to screen the anticancer activity of a crude extract of twigs of (a) Bombax anceps Pierre var. anceps (BA); (b) Catunaregam tomentosa (Bl...

    Authors: Natthida Weerapreeyakul, Cholpajsorn Junhom, Sahapat Barusrux and Thaweesak Thitimetharoch

    Citation: Chinese Medicine 2016 11:19

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  25. Content type: Research

    The processed roots of Polygonum multiflorum Thunb. (Heshouwu; processed HSW) are commonly used in anti-aging medicine. Few reports have combined chemical profiles with bioactivity to evaluate the quality of the ...

    Authors: Hai Fang Chen, You Hua Chen, Chun Hua Liu, Lu Wang, Xi Chen, Bo Yang Yu and Jin Qi

    Citation: Chinese Medicine 2016 11:18

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  26. Content type: Research

    SHINBARO is a refined herbal formulation used to treat inflamed lesions and bone diseases. This study aimed to investigate the anti-osteoarthritic activities of intra-articular administration of SHINBARO and d...

    Authors: Won Kyung Kim, Hwa-Jin Chung, Yuna Pyee, Tae Jun Choi, Hyen Joo Park, Ji-Young Hong, Joon-Shik Shin, Jin Ho Lee, In-Hyuk Ha and Sang Kook Lee

    Citation: Chinese Medicine 2016 11:17

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  27. Content type: Review

    Acupuncture therapy has been used to treat substance abuse. This study aims to review experimental studies examining the effects of acupuncture on addiction. Research and review articles on acupuncture treatme...

    Authors: Farid Esmaeili Motlagh, Fatimah Ibrahim, Rusdi Abd Rashid, Tahereh Seghatoleslam and Hussain Habil

    Citation: Chinese Medicine 2016 11:16

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  28. Content type: Research

    Jujube (Zǎo) seeds exhibited anticancer effects and used in Chinese medicine for many years. This study aims to investigate the apoptosis-inducing effects of seed extracts from eight different cultivated species ...

    Authors: Natthanan Taechakulwanijya, Natthida Weerapreeyakul, Sahapat Barusrux and Sirithorn Siriamornpun

    Citation: Chinese Medicine 2016 11:15

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  29. Content type: Research

    The discovery of anti-diabetic drugs is an active Chinese medicine research area. This study aims to map out anti-diabetic drug research in China using a network-based systemic approach based on co-authorship ...

    Authors: Junling Deng, Kaweng Sitou, Yongping Zhang, Ru Yan and Yuanjia Hu

    Citation: Chinese Medicine 2016 11:13

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  30. Content type: Research

    Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of tanshinone IIA for treating cardiovascular disorders. The roles of cytochrome P450 enzymes (CYPs) in the metabolism of STS have remained u...

    Authors: Dong-sheng Ouyang, Wei-hua Huang, Dan Chen, Wei Zhang, Zhi-rong Tan, Jing-bo Peng, Yi-cheng Wang, Ying Guo, Dong-li Hu, Jian Xiao and Yao Chen

    Citation: Chinese Medicine 2016 11:11

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  31. Content type: Research

    Quantitative real-time reverse transcription PCR (qRT-PCR) requires a stable internal control to avoid misinterpretation of data or errors for gene expression normalization. However, there are still no validat...

    Authors: Xin Zhang, Zhi-Chao Xu, Jiang Xu, Ai-Jia Ji, Hong-Mei Luo, Jing-Yuan Song, Chao Sun, Yuan-Lei Hu and Shi-Lin Chen

    Citation: Chinese Medicine 2016 11:8

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  32. Content type: Research

    Radix Salvia miltiorrhiza (Danshen) and Radix Puerariae lobatae (Gegen) are used in Traditional Chinese Medicine to treat cardiovascular diseases. However, adverse herb-drug interactions were observed between war...

    Authors: Beikang Ge, Zhen Zhang and Zhong Zuo

    Citation: Chinese Medicine 2016 11:7

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  33. Content type: Review

    Diabetic nephropathy (DN) is a severe micro vascular complication accompanying diabetes mellitus that affects millions of people worldwide. End-stage renal disease occurs in nearly half of all DN patients, res...

    Authors: Jing-Yi Liu, Xiao-Xin Chen, Sydney Chi-Wai Tang, Stephen Cho-Wing Sze, Yi-Bin Feng, Kai-Fai Lee and Kalin Yan-Bo Zhang

    Citation: Chinese Medicine 2016 11:6

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  34. Content type: Research

    This study aims to identify the major anti-inflammatory components in the petroleum ether extract of Bupleurum malconense (Chaihu), by bioassay-guided fractionation, and to investigate...

    Authors: Huai-Xue Mu, Cheng-Yuan Lin, Lin-Fang Huang, Da-Jian Yang, Ai-Ping Lu, Quan-Bin Han and Zhao-Xiang Bian

    Citation: Chinese Medicine 2016 11:5

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  35. Content type: Research

    Chinese medicine (CM) syndrome (zheng) differentiation is based on the co-occurrence of CM manifestation profiles, such as signs and symptoms, and pulse and tongue features. Insomnia is a symptom that frequently ...

    Authors: Wing-Fai Yeung, Ka-Fai Chung, Nevin Lian-Wen Zhang, Shi Ping Zhang, Kam-Ping Yung, Pei-Xian Chen and Yan-Yee Ho

    Citation: Chinese Medicine 2016 11:4

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  36. Content type: Research

    While DNA barcoding is an important technology for the authentication of the botanical origins of Chinese medicines, the suitable markers for DNA barcoding of the genus Uncaria have not been reported yet. This st...

    Authors: Yin-lin Tang, Yao-sheng Wu, Rui-song Huang, Nai-xia Chao, Yong Liu, Peng Xu, Ke-zhi Li, Dan-zhao Cai and Yu Luo

    Citation: Chinese Medicine 2016 11:3

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  37. Content type: Research

    Cycloartane triterpenoids exhibited anticancer effects. This study aims to identify any potential novel anticancer cycloartane triterpenoids from Cimicifuga foetida L. rhizome (Sheng ma) and the mode of actions.

    Authors: Hai-yan Sun, Bei-bei Liu, Jian-yang Hu, Li-jia Xu, Shun-wan Chan, Chi-on Chan, Daniel K. W. Mok, Dong-mei Zhang, Wen-cai Ye and Si-bao Chen

    Citation: Chinese Medicine 2016 11:1

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  38. Content type: Research

    Huangqi decoction (HQD) is used for liver fibrosis and cirrhosis treatment in Chinese medicine. This study aims to investigate the pharmacological actions of HQD against liver fibrosis...

    Authors: Gui-biao Zhang, Ya-nan Song, Qi-long Chen, Shu Dong, Yi-yu Lu, Ming-yu Su, Ping Liu and Shi-bing Su

    Citation: Chinese Medicine 2015 10:39

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  39. Content type: Research

    This study aims to analyze the active pharmaceutical ingredients (APIs) of licorice (Radix Glycyrrhizae; gancao), including glycyrrhizic acid, liquiritin, isoliquiritin and total flavonoids, in multi-ingredient a...

    Authors: Yang Li, Mingye Guo, Xinyuan Shi, Zhisheng Wu, Jianyu Li, Qun Ma and Yanjiang Qiao

    Citation: Chinese Medicine 2015 10:38

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  40. Content type: Research

    Some isoquinoline alkaloids from Macleaya cordata (Willd). R. Br. (Bo Luo Hui) exhibited antibacterial, antiparasitic, antitumor, and analgesic effects. The targets of these isoquinoline alkaloids are undefined. ...

    Authors: Qifang Lei, Haibo Liu, Yong Peng and Peigen Xiao

    Citation: Chinese Medicine 2015 10:37

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