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  1. Osteosarcoma is a malignant tumor of bone and soft tissue in adolescents. Due to its tumor biological behavior pattern, osteosarcoma usually generates poor prognosis. Autophagy is an important self-defense mec...

    Authors: Jiaming He, Wenkan Zhang, Xiaozhong Zhou, Weiqi Yan and Zhan Wang
    Citation: Chinese Medicine 2021 16:123
  2. Codonopsis pilosula, an important medicinal plant, can accumulate certain metabolites under moderate drought stress. Endophytes are involved in the metabolite accumulations within medicinal plants. It is still un...

    Authors: Yichuan Liang, Guangfei Wei, Kang Ning, Guozhuang Zhang, Youping Liu, Linlin Dong and Shilin Chen
    Citation: Chinese Medicine 2021 16:122
  3. Compound kushen injection (CKI), a Chinese patent drug, is widely used in the treatment of various cancers, especially neoplasms of the digestive system. However, the underlying mechanism of CKI in pancreatic ...

    Authors: Chao Wu, Zhi-Hong Huang, Zi-Qi Meng, Xiao-Tian Fan, Shan Lu, Ying-Ying Tan, Lei-Ming You, Jia-Qi Huang, Antony Stalin, Pei-Zhi Ye, Zhi-Shan Wu, Jing-Yuan Zhang, Xin-Kui Liu, Wei Zhou, Xiao-Meng Zhang and Jia-Rui Wu
    Citation: Chinese Medicine 2021 16:121
  4. Weifuchun (WFC), a Chinese herbal prescription consisting of Red Ginseng, Isodon amethystoides and Fructus Aurantii, is commonly used in China to treat a variety of chronic stomach disorders. The aim of the pa...

    Authors: Yanqin Bian, Xi Chen, Hongyan Cao, Dong Xie, Meiping Zhu, Nong Yuan, Lu Lu, Bingjie Lu, Chao Wu, Nisma Lena Bahaji Azami, Zheng Wang, Huijun Wang, Yeqing Zhang, Kun Li, Guan Ye and Mingyu Sun
    Citation: Chinese Medicine 2021 16:120
  5. Cardiomyopathy is a kind of cardiovascular diseases, which makes it more difficult for the heart to pump blood to other parts of the body, eventually leading to heart failure. Naoxintong (NXT), as a traditiona...

    Authors: Mengyan Hu, Peirong Liu, Shuxian Lu, Zhihao Wang, Zhaojie Lyu, Hongkai Liu, Yuhong Sun, Feng Liu and Jing Tian
    Citation: Chinese Medicine 2021 16:119
  6. Buyang Huanwu Decoction (BHD) is a classical Chinese Medicine formula empirically used for diabetic nephropathy (DN). However, its therapeutic efficacies and the underlying mechanisms remain obscure. In our st...

    Authors: Weifeng Wu, Yifan Wang, Haidi Li, Haiyong Chen and Jiangang Shen
    Citation: Chinese Medicine 2021 16:118
  7. Irritable bowel syndrome (IBS) is a common gastrointestinal functional disease. Adults with IBS may experience abdominal pain, change of bowel habits, and abnormal stool form without organic disease. IBS can s...

    Authors: Ya Zheng, Jessica Ching, Chung Wah Cheng, Wai Ching Lam, Kam Leung Chan, Xuan Zhang, Pui Yan Lam, Xing Yao Wu, Linda L. D. Zhong, Pei Hua Cao, Cho Wing Lo, Pui Kuan Cheong, Zhixiu Lin, Matthew Koh, Justin Wu and Zhao Xiang Bian
    Citation: Chinese Medicine 2021 16:117
  8. Arsenic (As3+) is a carcinogen with considerable environmental and occupational relevancy. Its mechanism of action and methods of prevention remain to be investigated. Previous studies have demonstrated that ROS ...

    Authors: Yuan-Ye Dang, Hua Luo, Yong-Mei Li, Yang Zhou, Xiu Luo, Shui-Mu Lin, Shou-Ping Liu, Simon Ming-Yuen Lee, Chu-Wen Li and Xiao-Yan Dai
    Citation: Chinese Medicine 2021 16:116
  9. Non-alcoholic fatty liver disease (NAFLD) is characterized by ectopic accumulation of triglycerides in the liver. Emerging evidence has demonstrated that lipophagy regulates lipid mobilization and energy homeo...

    Authors: Jingxin Liu, Tian Zhang, Jianzhong Zhu, Shuangchen Ruan, Rongsong Li, Bing Guo and Ligen Lin
    Citation: Chinese Medicine 2021 16:115
  10. Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease dominated by synovial hyperplasia and bone destruction. The male flower of Eucommia ulmoides Oliv. (EF) has been shown to exert effects on the in...

    Authors: Yan Zhang, Jian-Ying Wang, Hao Wang, Xiao-Yun Chen, Lei Zhang and Ying Yuan
    Citation: Chinese Medicine 2021 16:113
  11. Fibrotic liver injury is a progressive scarring event, which may permanently affect liver function and progress into devastating end-stage liver diseases due to the absence of effective therapies. Si-Wu-Tang (...

    Authors: Xiaoyong Xue, Jianzhi Wu, Mingning Ding, Feng Gao, Fei Zhou, Bing Xu, Mingjun Lu, Jun Li and Xiaojiaoyang Li
    Citation: Chinese Medicine 2021 16:112
  12. Common chronic wounds include diabetic ulcers, venous ulcers, and pressure ulcers. The traditional Chinese medicine Huiyang Shengji decoction (HYSJD) has been shown to promote the healing of diabetic chronic w...

    Authors: Qingwu Liu, Jinchao Zhang, Xuyang Han, Jia Chen, Yating Zhai, Yan Lin, Huike Ma, Fang Feng, Xiujuan He and Ping Li
    Citation: Chinese Medicine 2021 16:111
  13. Uncaria tomentosa, which has similar chemical constituents with Uncaria rhynchophylla, has been reported to alleviate cognitive impairments in Alzheimer’s disease (AD) animal models. This study aimed to compare t...

    Authors: Qing-Qing Xu, Pang Chui Shaw, Zhen Hu, Wen Yang, Siu-Po Ip, Yan-Fang Xian and Zhi-Xiu Lin
    Citation: Chinese Medicine 2021 16:110
  14. Traditional Chinese Medicine (TCM) is distinguished by Syndrome differentiation, which prescribes various formulae for different Syndromes of same disease. This study aims to investigate the underlying mechanism.

    Authors: Gaosong Wu, Jing Zhao, Jing Zhao, Nixue Song, Ningning Zheng, Yuanyuan Zeng, Tingting Yao, Jingfang Zhang, Jieqiong Weng, Mengfei Yuan, Hu Zhou, Xiaoxu Shen, Houkai Li and Weidong Zhang
    Citation: Chinese Medicine 2021 16:109
  15. Coronary heart disease (CHD) is a common ischaemic heart disease whose pathological mechanism has not been fully elucidated. Single target drugs, such as antiplatelet aggregation, coronary artery dilation and ...

    Authors: Tian-Yi Cheng, Jia-Xin Li, Jing-Yi Chen, Pei-Ying Chen, Lin-Rui Ma, Gui-Lin Zhang and Pei-Yu Yan
    Citation: Chinese Medicine 2021 16:108
  16. Lily Bulb and Rehmannia Decoction (LBRD), is a traditional Chinese formula that has been shown to be safe and effective against depression; however, its material basis and pharmacological mechanisms remain unk...

    Authors: Hongxiu Zhang, Xiaoyan Xue, Jin Pan, Xiaobin Song, Xing Chang, Qiancheng Mao, Yanting Lu, Haijun Zhao, Yuan Wang, Xiansu Chi, Shijun Wang and Ke Ma
    Citation: Chinese Medicine 2021 16:107
  17. The wide spread of plasmid-mediated colistin resistance by mobile colistin resistance (MCR) in Enterobacteriaceae severely limits the clinical application of colistin as a last-line drug against bacterial infe...

    Authors: Qiushuang Sheng, Runbao Du, Cunhui Ma, Yonglin Zhou, Xue Shen, Xiaoning Hou, Lei Xu, Li Li, Xuming Deng and Jianfeng Wang
    Citation: Chinese Medicine 2021 16:106
  18. Neonatal hypoxic-ischemic encephalopathy (HIE) refers to the perinatal asphyxia caused by the cerebral hypoxic-ischemic injury. The current study was aimed at investigating the therapeutic efficacy of Scutella...

    Authors: Rui-Ze Niu, Liu-Lin Xiong, Hao-Li Zhou, Lu-Lu Xue, Qing-Jie Xia, Zheng Ma, Yuan Jin, Li Chen, Ya Jiang, Ting-Hua Wang and Jia Liu
    Citation: Chinese Medicine 2021 16:105
  19. Syndrome differentiation is a commonly used methodology and practice in Traditional Chinese Medicine (TCM) guiding the diagnosis and treatment of diseases including heart failure (HF). However, previous clinic...

    Authors: Alice Yeuk Lan Leung, Hoiyong Chen, Zhenhua Jia, Xinli Li and Jiangang Shen
    Citation: Chinese Medicine 2021 16:103
  20. Atopic dermatitis (AD) is a chronic relapsing skin disease characterized by recurring episodes of itchiness with skin erythema and surface damages. Chinese medicine (CM) is widely used for the management of AD...

    Authors: Chi Him Sum, Jessica Ching, Hongwei Zhang, Steven Loo, Cho Wing Lo, Mei Kwan Lai, Pui Kuan Cheong, Chau Leung Yu and Zhi-xiu Lin
    Citation: Chinese Medicine 2021 16:101
  21. American ginseng (AG) is a valuable medicine widely consumed as a herbal remedy throughout the world. Huge price difference among AG with different growth years leads to intentional adulteration for higher pro...

    Authors: Xiaowen Hu, Hua Yan, Xiaodong Wang, Zonghu Wang, Yuanpeng Li, Lianjun Zheng, Jianbo Yang, Wenguang Jing, Xianlong Cheng, Feng Wei and Shuangcheng Ma
    Citation: Chinese Medicine 2021 16:100
  22. Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China. It consists of three herbs, namely Eclipta prostrata (L.) L....

    Authors: Qiaofeng Li, Taijin Lan, Songhua He, Weiwei Chen, Xiaolan Li, Weiquan Zhang, Ying Liu, Qiuping Zhang, Xin Chen, Yaoyao Han, Zhiheng Su, Dan Zhu and Hongwei Guo
    Citation: Chinese Medicine 2021 16:99
  23. Dried fruits of Psoralea corylifolia L. (Psoraleae Fructus) is one of the most popular traditional Chinese medicine with treatment for nephritis, spermatorrhea, pollakiuria, asthma, and various inflammatory disea...

    Authors: Qingxia Xu, Qian lv, Lu Liu, Yingtao Zhang and Xiuwei Yang
    Citation: Chinese Medicine 2021 16:98
  24. Chinese herbal medicine (CHM) has significant effects that improve the reproductive functions of patients with polycystic ovary syndrome (PCOS). However, the intergenerational effects of CHM on offspring and t...

    Authors: Xian Zhang, Lifang You, Xiaohui Zhang, Fangfang Wang, Yi Wang, Jue Zhou, Chang Liu and Fan Qu
    Citation: Chinese Medicine 2021 16:97
  25. Rheumatoid arthritis is a progressive and systemic autoimmune disease seriously compromises human health. Fibroblast like synoviocytes are the major effectors of proliferation and inflammation in rheumatoid ar...

    Authors: Lianhua He, Huijie Luan, Juan He, Miaomiao Zhang, Qingxia Qin, Yiping Hu, Yueming Cai, Desheng Sun, Yu Shi and Qingwen Wang
    Citation: Chinese Medicine 2021 16:96
  26. Chinese materia medica processing is a distinguished and unique pharmaceutical technique in Traditional Chinese Medicine (TCM) used for reducing side effects, and increasing or even changing therapeutic effica...

    Authors: Zhe Li, Lkhaasuren Ryenchindorj, Bonan Liu, Ji Shi, Chao Zhang, Yue Hua, Pengpeng Liu, Guoshun Shan and Tianzhu Jia
    Citation: Chinese Medicine 2021 16:95
  27. Marchantia polymorpha L. is a kind of Chinese herbal medicine and has various biological activities including antioxidant and antifungal. However, it is not clear about the antitumor effect and mechanism of M. po...

    Authors: Fangfang Zhou, Adila Aipire, Lijie Xia, Xierenguli Halike, Pengfei Yuan, Mamtimin Sulayman, Weilan Wang and Jinyao Li
    Citation: Chinese Medicine 2021 16:94
  28. The Gouqi-wentang formula (GQWTF) is a herbal formula used by Academician Xiao-lin Tong for the clinical treatment of T2DM. GQWTF is beneficial to qi, nourishes Yin, clears heat, and promotes fluid production,...

    Authors: Lin Han, Hao-yu Yang, Yu-jiao Zheng, Xiu-xiu Wei, Wen-chao Dan, Li-li Zhang, Qi-you Ding, Xu Ma, Xin-miao Wang, Lin-hua Zhao and Xiao-lin Tong
    Citation: Chinese Medicine 2021 16:93
  29. The oral colon-targeting drug delivery vehicle is vital for the efficient application of curcumin (Cur) in ulcerative colitis (UC) treatment because of its lipophilicity and instability in the gastrointestinal...

    Authors: Chen Zhang, Zhejie Chen, Yanan He, Jing Xian, Ruifeng Luo, Chuan Zheng and Jinming Zhang
    Citation: Chinese Medicine 2021 16:92
  30. Epimedin C, one of the main active ingredients of Epimedium, has been reported to have potential hepatotoxicity. However, the mechanism of Epimedin C-induced liver injury has not been studied. mRNA methylation...

    Authors: Zhizhen Song, Zeyun Li, Xueqian Wen, Ruijuan Liu and Xin Tian
    Citation: Chinese Medicine 2021 16:91
  31. Bungarus multicinctus, from which a classical Chinese medicine is produced, is known as the most venomous land snake in the world, but the chromatin organization and transcription factor activity during venom rep...

    Authors: Xuejiao Liao, Shuai Guo, Xianmei Yin, Baosheng Liao, Mingqian Li, He Su, Qiushi Li, Jin Pei, Jihai Gao, Juan Lei, Xiwen Li, Zhihai Huang, Jiang Xu and Shilin Chen
    Citation: Chinese Medicine 2021 16:90
  32. Fagopyrum dibotrys (F. dibotrys) (D.Don) H.Hara is a well-known edible herbal medicine in Asian countries. It has been widely used for the treatment of lung diseases, swelling, etc., and is also an important par...

    Authors: Le-Le Zhang, Yan He, Feiya Sheng, Ying-Fan Hu, Yu Song, Wei Li, Jiarong Chen, Jinming Zhang and Liang Zou
    Citation: Chinese Medicine 2021 16:89
  33. Amending from ancient classic, Ziyin Tongluo Formula (ZYTLF) has been prescribed to treat postmenopausal osteoporosis (PMOP) for decades with good curative effect. However, the possible mechanisms of it are st...

    Authors: Rong-Bin Chen, Ying-Dong Yang, Kai Sun, Shan Liu, Wei Guo, Jin-Xin Zhang and Yong Li
    Citation: Chinese Medicine 2021 16:88
  34. Microwave technology is used throughout the world to generate heat using energy from the microwave range of the electromagnetic spectrum. It is characterized by uniform energy transfer, low energy consumption,...

    Authors: Qi Hu, Yanan He, Fang Wang, Jing Wu, Zhimin Ci, Lumeng Chen, Runchun Xu, Ming Yang, Junzhi Lin, Li Han and Dingkun Zhang
    Citation: Chinese Medicine 2021 16:87
  35. With the advanced discoveries in the field of pathogenesis, a series of cerebral diseases, such as cerebral ischaemia, Alzheimer's disease, and depression, have been found to have multiple signalling targets i...

    Authors: Wenwen Zhang, Fangling Zhang, Qichao Hu, Xiaolin Xiao, Linbo Ou, Yuan Chen, Shiqing Luo, Yonghong Cheng, Yinxiao Jiang, Xiao Ma and Yanling Zhao
    Citation: Chinese Medicine 2021 16:86
  36. Belamcanda chinensis (L.) DC. (BC) belongs to the family of Iridaceae and is widely cultivated and used in many Chinese patent medicine and Chinese medicinal formulae. However, due to the high similarities in app...

    Authors: Hongxu Zhou, Yi Zhang, Hui Liang, Huijie Song, Jiaming Zhao, Li Liu, Jun Zeng, Lei Sun, Shuangcheng Ma and Dali Meng
    Citation: Chinese Medicine 2021 16:85
  37. Filifolium sibiricum (L.)Kitam (F. sibiricum), a compositae plant, is especially used to inhibit drug-resistant bacteria in folk medicine. Modern pharmacological studies also confirmed a variety of pharmacologica...

    Authors: Shaowa Lv, Qian Qiu, Qiuhong Wang and Haixue Kuang
    Citation: Chinese Medicine 2021 16:83
  38. Post-ischemic inflammation is a crucial component in stroke pathology in the early phase of cerebral ischemia–reperfusion (I/R) injury. Inflammation caused by microglia, astrocytes, and necrotic cells, produce...

    Authors: Chin-Yi Cheng, Su-yin Chiang, Shung-Te Kao and Shang-Chih Huang
    Citation: Chinese Medicine 2021 16:82
  39. Accumulating evidence indicated that necroptosis plays an essential role in the pathogenesis of inflammatory bowel disease (IBD). The O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) of necroptotic signal m...

    Authors: Fan Wu, Qingqing Shao, Zhe Cheng, Xinyu Xiong, Ke Fang, Yan Zhao, Ruolan Dong, Lijun Xu, Fuer Lu and Guang Chen
    Citation: Chinese Medicine 2021 16:78
  40. Chaihu-Shugan-San (CSS, named Shihosogansan in Korean), a Chinese traditional medicine, is frequently used to treat anxiety and depression. Psychiatric disorders including depression are associated with gut dy...

    Authors: Sang-Kap Han, Jeon-Kyung Kim, Hee-Seo Park, Yeun-Jeong Shin and Dong-Hyun Kim
    Citation: Chinese Medicine 2021 16:77
  41. Paclitaxel-induced peripheral neuropathy (PIPN) is a challenging clinical problem during chemotherapy. Our previous work found that herbal formula Huangqi Guizhi Wuwu decoction (HGWD) could reduce oxaliplatin-...

    Authors: Zhangming Lv, Jiayun Shen, Xuejiao Gao, Yonglan Ruan, Jinying Ling, Rongwei Sun, Jingya Dai, Haizhen Fan, Xiaolan Cheng and Peng Cao
    Citation: Chinese Medicine 2021 16:76
  42. Ulcerative colitis (UC) is an important inflammatory phenotype in bowel disease (IBD), which is caused by multiple potential factors, including fungal dysbiosis. Candida albicans (C. albicans) was confirmed to be...

    Authors: Zhijun Han, Xiaofen Tan, Juan Sun, Tianming Wang, Guiming Yan, Changzhong Wang and Kelong Ma
    Citation: Chinese Medicine 2021 16:75
  43. With the advances in biomedical technologies, natural products have attracted substantial public attention in the area of drug discovery. Flavonoids are a class of active natural products with a wide range of ...

    Authors: Qichao Hu, Caiyan Qu, Xiaolin Xiao, Wenwen Zhang, Yinxiao Jiang, Zhao Wu, Dan Song, Xi Peng, Xiao Ma and YanLing Zhao
    Citation: Chinese Medicine 2021 16:74