- Open Access
Indigenous medicinal plants of Pakistan used to treat skin diseases: a review
© The Author(s) 2018
- Received: 13 May 2018
- Accepted: 11 October 2018
- Published: 19 October 2018
Plants are providing reliable therapy since time immemorial. Pakistan has a great diversity in medicinal flora and people use these ethno-medicines to deal with many skin problems. This review explores the fundamental knowledge on various dermatological properties of medicinal plants of Pakistan and is aimed to provide a baseline for the discovery of new plants having activities against skin issues.
Material and method
A total of 244 published articles were studied using different research engines like PubMed, Google, Google-scholar and science direct.
Review of literature revealed ethno-pharmacological use of 545 plant species, belonging to 118 families and 355 genera, to combat various skin ailments. Out of these, ten most commonly used plant species belonging to ten different families are documented in this review. It was also found out that ehno-medicines are prepared using various parts of the plants including leaves (28.32%), whole plant and roots 13.17% and 10.97% respectively, in the form of powder (23.5%) and paste (22.75%). A total of 13 endangered plant species and ten commercially important plants were recorded.
Medicinal plants of Pakistan have therapeutic effects against several skin problems; however most of medicinal plants are still not evaluated scientifically to support their ethno-pharmacological claim on skin. Dermatological pathogens are recommended to study. Further, the conservational programs should be established for endangered species.
- Medicinal flora
- Skin problems
- Dermatological pathogens
History of natural products is as old as human civilizations and so is the Indigenous knowledge, which is handed down to the people from their ancestors through verbal communication; people have been living in close association with plants since time immemorial . The purpose of standardizing traditional remedies is, obviously, to ensure therapeutic efficacy of medicinal plants; whereas the value of ethno-medicinal information in modern pharmacology lies in the development of new drugs. Some modern drugs have been deducted from folklore and traditional medicines . The origin of the word “Ethnobotany” is accredited to US ethnobotanist “John Harshberger” who described and explained the relationship between people and plants they use in a culture in 1895 [1, 3]. In Sub-continent, Rig Veda (4500–1600 BC) compiled first record of ethno-medicine .
In ancient times, natural products were successfully used to treat different ailments owing to their enhanced acceptability in human society, better compatibility with the body and their natural power to treat ailment via synergistic effects and neutralizing combinations to lessen adverse effects . Medicinal plants are better as compared to synthetic drugs because of minimal adverse reactions [6, 7]. Medicinal plants (trees, shrubs, grasses or vines) can be used in different forms  like extracts, in fresh or powdered form, seeds, fruits, vegetable mixtures, etc. .
According to an estimate, earth carries 265,000 species of plants but only half of these are yet investigated for their medicinal values and chemical composition. In developing countries, around 80% of the population depends upon medicinal plants for combating different diseases but this was estimated about a decade ago [10, 11] while in developed countries, 60% of the population uses these plants , 40–50% of the population in Germany, 42% in the USA, 48% in Australia and 49% in France depends upon plants for different health issues . Importance of these medicinal plants can be judged by the fact that at least 25% of the drugs enlisted in modern Pharmacopoeia are of plant origin . Also about 25% of the medical prescriptions are based on the substances or analogs of the substances of plant origin .
Pakistan occupies 80,943 km2 area and lies between 60°55′ to 75°30′ E longitude and 23°45′ to 36°50′ N latitude , and has altitude ranges from 0 to 8611 m with a mixed climate zones; has a large biodiversity of the medicinal plants. Pakistan is blessed with 6000 species of higher plants, of which 600–700 are used medicinally , out of these 6000 species, half (3000 species) are reported from Northern areas out of which 124 species have medicinal importance [16, 17], 4940 flowering plants are native to Pakistan (if cultivated flowering species are included figure turns 5738) . Unfortunately only 10% of the total plant species in Pakistan have reported medicinal values .
In Pakistan, a large population uses folk medicines and it has become a definite part of its cultural heritage . In early 1950s, most of the health concerned issues were treated using traditional indigenous experiences by more than 84% of the population of Pakistan but now this practice is limited to only remote areas of the country [6, 20, 21]. In 1958, Hocking also reported same percent (84%) of Pakistan population depending upon traditional medicinal plants for treating different ailments. In 1983, 63% of the population in Pakistan, especially in villages, was reported to use herbal medicines prescribed by the traditional prescribers . Knowledge on the use of medicinal plants is enormous but if this traditional knowledge is not rapidly researched and recorded, indications are that it will be lost with succeeding generations .
Skin, the most diverse organ of the human body, is very important for aesthetic reasons and health issues. Skin diseases not only give unfavorable looks but also pushes the patient into psychic conditions . It has been estimated that skin diseases account for 34% of all occupational disease . Despite of all the developments in the medical science, it is still complicated to manage skin diseases specifically in developing countries, due to the fact that health care workers lack training in skin care and skin diseases, which have been of major concern, recently, due to their association with the Human Immunodeficiency Virus and Acquired Immunity Deficiency Syndrome (HIV/AIDS) . Since human civilization, plants are used to treat major skin issues like wounds, cuts and burns . In a study, it was documented that 80% of the Indian population uses ethno-medicines to deal with skin problems and 50% of the medicinal plants used against skin problems are restricted to forest .
This review is an attempt to summarize utmost possible information on ethno-medicines and pharmacology of the plants used in Pakistan to cure skin diseases. This study was aimed to investigate the ethno-medicinal uses of the plants of Pakistan to treat various skin conditions. We were interested in gathering the answers of the following questions in particular: Which plant species are most commonly used traditionally for skin problems? Which skin conditions are most commonly treated using ethno-medicine? Which parts of medicinally important flora of Pakistan are used against skin diseases? What are the recipes for preparing and applying the ethno-medicines? Above all, the review will identify gaps in the current knowledge that will provide a baseline for further research activities. Also, the review is aimed to highlight the area of Pakistan still need to be investigated.
Published papers were retrieved from the online bibliographical database latest till June 2015, search engines included: PubMed, Google, Google.scholar, IUNCredlist, druginfosys and sciencedirect. Inside the database, we used the keywords like traditional plants for skin, ethnobotany of Pakistan, ethno-medicine, traditional uses of plants, indigenous plant knowledge, plants used in ethno-pharmacology. While reviewing the literature, focus was on the plants with the potential traditional usage against various diseases of skin. In total, 244 articles on Indigenous plants of Pakistan published in English language were reviewed for this study for the period March 2015 to December 2017. Articles selected for this review contain plants that were (i) native to Pakistan with some wide distribution (ii) traditionally used in Pakistan for treating skin diseases; only those plants were selected that have ethno-pharmacological evidence for skin treatment. A master document was formulated enlisting indigenous medicinal plants of Pakistan used by the local inhabitants for the treatment of several skin ailments. Master list constituted vernacular name of the medicinal plants along with the family name, part used, mode of preparation, life form and skin conditions against which the plant is being used. All the data were summarized into 6 tables and 9 figures.
As this review is written after consulting a large number of articles, only references are provided in it due to vey diversified data.
The data collected were grouped into 26 categories on the basis of skin conditions; 28 categories based on families plant belong to; 7 categories based on mode of preparation of medicine, 30 categories based on the part used, 9 categories based on habit of plants and 6 categories based on the region the plant grows.
Plants reported in more than one region of Pakistan were enlisted only once for making the final list of medicinal plants. Conservation status was evaluated following IUCN red list categories version 3.1 and the herbal products registered in Pakistan and economical importance of the plants was estimated by consulting druginfosys.com and scientific literature respectively.
Several taxonomic problems were observed in the development of this manuscript. Entirely, we documented 10 plant species most frequently used by the people of Pakistan against skin diseases, there were some spelling mistakes in family names, botanical names, publication and authors, which were also verified according to “http://www.google.com”, “http://www.tropicos.org” and “http://www.plantlist.org”.
List of plants used traditionally against skin conditions
Calotropis procera (Aiton) R. Br.
Dasi ak, Milk weed, Akk, Spalmaka, wallow-wort, Sodom apple, Dead Sea apple
St, bk, lf, sd, rt, fr, wp
(1) Decoction of stem and leaves is taken
(2) Latex is mixed with castor oil and applied
(3) Paste with raw sugar is applied over the dog bitten wounds
(4) Flowers are put in oil & applied on wounds
(5) Crushed leaves
(6) The leaves are warmed and tied over the wounds and used as poultice
(7) Roots are powdered, mixed with “desi ghee” and pasted on points of leprosy
Leprosy, wound healing, abscess, ringworm, dog bitten wounds, eczema, pustules and pimples, skin eruptions, syphilis, boils, ulcer, burn, dermatitis, scabies, infection and other skin diseases
Anti-hyperbilirubinemic and wound healing activity of aqueous extract of Calotropis procera leaves in Wistar rats 
Calotropis procera extract induces apoptosis and cell cycle arrest at G2/M phase in human skin melanoma (SK-MEL-2) cells 
Wound-healing and potential anti-keloidal properties of the latex of Calotropis procera (Aiton) Asclepiadaceae in rabbits 
Wound healing in diabetes mellitus: traditional treatment modalities 
Healing potential of Calotropis procera on dermal wounds in Guinea pigs 
Procerursenyl acetate, proceranol, N-dotriacont-6-ene, glyceryl mono-oleolyl-2-phosphate, methyl myrisate, methyl behenate and glyceryl-1,2-dicapriate-3-phosphate 
Berberis lyceum Royle
Sumblu, komal, Kowdach, Berberry, Churku, Ishkeen, Ishkin (Urdu), Ishkein (Shina), Sumbal
Rt, st, br, lf, fr
(1) The paste of root and bark is externally applied on wounds
(2) Crushed bark is soaked in water and the extract is taken in morning to treat scabies, boils and pimples
(4) Dried root mixed with egg and fried in cow’s ghee is used
(5) Dried powdered root is spread over external wounds
(6) For external wounds peel off an epidermis of root and boil the inner cortex
(7) Bark powder paste mixed with mustard oil is used
Gonorrhea, wound healing, ulcers, Scabies, Boils, Pimples
Wound healing activity of root extracts of Berberis lyceum royle in rats 
Berberine, ß-sitosterol, 4,4-dimethylhexadeca-3-ol, butyl-3-hydroxypropyl phthalate, 3-(4′-(6-methyl butyl) phenyl)p ropan-1-ol, 4-methyl-7-hydroxycoumarin 
Dodonaea vescosa (L.) Jacq.
Ghwara-sky, Sanatha, Anartirk/Hanartirk
Wp, Lf, sd, Bk, wd, rt, fl
(1) Paste of dried powdered leaves and water is applied
(2) Fresh leaves are crushed to the extent to become sticky and then tied on the effected part of the body for wounds healing
(4) Leaves are grinded, mixed in water and bath is taken with this water
(6) Dry leaves are tied on wounds and used for softening of wound
Swelling, Germicidal, pimples, Burn and wound healing, cracked skin, rashes, itching and pustules, allergy
Antifungal activity of Dodonaea viscosa Jacq extract on pathogenic fungi isolated from superficial skin infection 
Toxicity studies on dermal application of plant extract of Dodonaea viscosa used in Ethiopian traditional medicine 
Antifungal activity of the plant Dodonaea viscosa var. Angustifolia on Candida albicans from HIV-infected patients 
Sakuranetin, leucocynindns, quercetin, kaempferol, isorhamnetin, 5,7,4′-trihydroxy-3′-(3hydroxymethylbutanol) 3,6-dimethoxyflavone, 5,7-dihydroxyflavanone, 5,4′-dihydroxy-3,6,7-trimethoxy flavone, 3′-(γ,γ-dimethyalllyl)-5,7-dihydroxy-3,6,4′-trimethoxyflavone, 3,5,7,4′-Tetrahydroxyl-3,4′-dimethoxyflavone, 5,4′-dihydroxy-6,7-dimethoxyflavone, 5,7-dihydroxy-6, 4′-dimethoxyflavone, 3,5-dihydroxy-7,4′-dimethoxyflavone, 5-hydroxy-3,7,4′-trimethoxyflavone, trimethoxy flavone, 5 hydroxy-7,4′-dimethoxyflavone, 6 Hydroxy-3,6,7 trimethoxyflavone, 5,7,4′ Trihydroxy-3-methoxyflavone 
Achyranthes aspera L.
Apang, Puth Kanda, Prickly flower, Jishkay
lf, st, sd, wp
(1) Ash of leaves and stem
(4) Paste of leaves
leprosy, Itching, Skin eruptions and irritation, abscess and boils, ulcer and other Skin diseases
Cancer chemopreventive activity of Achyranthes aspera leaves on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis 
Antibacterial activities of selected medicinal plants in traditional treatment of human wounds in Ethiopia 
In vivo wound-healing efficacy and antioxidant activity of Achyranthes aspera in experimental burns 
Evaluation of in vivo wound healing activity of methanol extract of Achyranthes aspera L. 
Anti-herpes virus activities of Achyranthes aspera: an indian ethnomedicine, and its triterpene acid 
Pharmacological evaluation and chemical standardization of an ayurvedic formulation for wound healing activity 
α-l-Rhamnopyranosyl-(1 → 4)-(β-d-glucopyranosyluronic acid)-(1 → 3)-oleanolic acid, α-l-rhamnopyranosyl-(1 → 4)-(β-d-glucopyranosyluronic acid)-(1 → 3)-oleanolic acid-28-O-β-d-glucopyranoside and α-l-rhamnopyranosyl-(1 → 4)-(β-d-glucopyranosyluronic acid)-(1 → 3)-oleanolic acid-28-O-β-d-glucopyranosyl-(1 → 4)-β-d-glucopyranoside, n-hexacos-14-enoic acid, strigmasta-5, 22-dien-3-β-ol, trans-13-docasenoic acid, n-hexacosanyl, n-decaniate, n-hexacos-17-enoic acid and n-hexacos-11-enoic acid, 36, 37-dihydroxyhenpentacontan-4-one and Triacontanol, β-d-glucopyranosyl3β-[O-α-l-rhamnopyranosyl-(1 → 3)-O-β-d-glucopyranuronosyloxy]machaerinate, β-d-glucopyranosyl3β-[O-β-d-galactopyranosyl-(1 → 2)-O-α-d-glucopyranuronosyloxy]machaerinate, β-d-glucopyranosyl-3β[O-α-l-rhamnopyranosyl-[1 → 3)-O-β-d-glucopyranuronosyloxy]oleanolate, β-d-glucopyranosyl3-β-[O-β-d-galactopyranosyl (1 → 2)-O-β-d-glucopyranuronosyloxy] oleanolate, β-d-glucopyranosyl 3β-[O-β-d-glucopyranuronosyloxy]
Nerium oleander L.
Kaner, Gndeer, Ganaera, Gandeera
Rt, Lf, Bk, Br
(1) Oil extracted from the root and bark
(3) Leaves with honey used as a poultice
Scabies, ulcers, leprosy and scaly skin, Gangrine, maggots infesting wounds
Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an Aloe vera-based extract of Nerium oleander leaves 
Nériine, digitoxigénine, Amorphane, 1.8-cineole, α-pinene, calarene, Limonene, βPhellandrene, Terpinene-4-ol, sabinene, Isoledene, 3-Carene, Humulene, β-Pinene and Cymen-8-ol 
Riccinus communis L.
Arand, Raned, Hurnoli
Wp, Sd, lf, bk, rt
(1) Grinded leaves
(2) Oil obtained from the seeds
(3) Paste of leaves is slightly warmed over fire and applied
Freckles, scabies, wounds and sores healing, boils, acne, leprosy, ringworm, swelling, warts removal and other skin diseases
Some Nigerian plants of de rmatologic importance 
Antimicrobial activity of Palestinian medicinal plants against acne-inducing bacteria 
In vitro assessment of cytotoxicity, antioxidant, and anti-inflammatory activities of Ricinus communis (Euphorbiaceae) Leaf Extracts 
Natural pharmacopoeia used in traditional Toba medicine for the treatment of parasitosis and skin disorders (Central Chaco, Argentina) 
Effect of Solanum nigrum and ricinus communis extracts on histamine and carrageenan-induced inflammation in the chicken skin 
Ricinine, N-demethylricinine, glycosides kaempferol-3-O kaempferol-3-O-β-d-glucopyranoside, quercetin
Xylopyranoside, quercetin-3-O-β-d-glucopyranoside, kaempferol
O-β-rutinoside and quercetin-3-O-β rutinoside, 1, 8-cineole, camphor and α-pinine (β-caryophyllene, ricinoleic, isoricinoleic, stearic and dihydroxystearic acids, ricinine, ester form of palmitic, stearic, arachidic, hexadecenoic, oleic, linoleic, linolenic, ricinoleic (89.4%) and dihydroxy stearic acids, ergost—en-3-ol, stigmasterol, Y-sitosterol, fucosterol; and probucol 
Carthamus tinctorious L.
Pome, Pong, Tukhmigartum, Safflower
Fl, sd, lf
Chicken pox, measles and eruptive skin problems
Inhibitory effects of active compounds isolated from safflower (Carthamus tinctorius L.) Seeds for melanogenesis 
Kinetic study on the tyrosinase and melanin formation inhibitory activities of carthamus yellow isolated from Carthamus tinctorius L. 
Inhibitory effect of hydroxysafflor yellow a on mouse skin photoaging induced by ultraviolet irradiation 
Enzyl-O-β-d-glucopyranoside, syringarenol, lirioresinol-A, 5-hydroxymethyl-2-furaldehyde, β-sitosterol, and stigmasterol 
Solanum nigrum L.
Mako, Black Nightshade
Wp, Ber, lf, Ft, Lf, st
(1) The juice of the ripen berries is applied on the skin
(3) Crushed leaves
(4) Fruits are crushed and applied externally
Cosmetics, dried skin, pimples, freckles, as sun block, corrosive ulcer and suppurating Syphilitic ulcer, Pustules, ring worms, wounds healing, eczema, leukoderma
Effect of Solanum nigrum and Ricinus communis extracts on histamine and carrageenan-induced inflammation in the chicken skin 
(+)-pinoresinol (I), (+)-syringaresinol (II), (+)-medioresinol (III), scopoletin (IV), tetracosanoic acid (V) and beta-sitosterol 
Albizia lebbeck (L.) Benth
Lf, sd, bk, fl, st, wd, tr
(1) Dried leaves are smoked
(2) Paste of flower
Wound healing, leucoderma, itching, Inflammations, boils, eruption
Wound-healing potential of the root extract of Albizzia lebbeck 
Budmunchiamines L1–L3, Quercetin, kaempferol, 3-O-α-rhamnopyranosyl (1 → 6)-β-glucopyranosyl(1 → 6)-β-galactopyranosides and Albiziasaponins A, B and C 
Plantago lanceolata L.
Bar-e-Thang, Boieko-ligini, Isphaghol, Ghwa jabai
Lf, ft, sd, rt
(1) Fresh leaves are mashed and put on wounds
Wound and burn healing, Skin sores, inflamed surfaces, bruises
Plantago lanceolata L. Water extract induces transition of fibroblasts into myofibroblasts and increases tensile strength of healing skin wounds 
catalpol, aucubin, and acteoside 
Distribution of plants in different regions of Pakistan
Investigated and under-investigated districts for ethno-botanical studies
Investigated districts for ethno-botanical studies
Under-investigated districts for ethno-botanical studies
Attock, Bahawalnaga, Bahawalpur, Bhakkar, Chakwal, Dera Ghazi Khan, Faisalabad, Gujranwala, Gujrat, Jhang, Jhelum, Kasur, Khushab, Mianwali, Multan, Muzaffargarh, Narowal, Nankana Sahib, Pakpattan, Rajanpur, Rawalpindi, Sahiwal, Sargodha, Sialkot, Toba Tek Singh, Vehari
Chiniot, Hfizabad, Khanewal, Okara, Rahim Yar Khan, Sheikhupura
Abbottabad, Bannu, Battagram, Buner, Chitral, Dera Ismail Khan, Haripur, Karak, Kohat, Upper Kohistan, Lakki Marwat, Lower Dir, Malakand, Mansehra, Peshawar, Swat, Upper Dir, Lower Kohstan
Charsadda, Hangu, Mardan, Nowshera, Shangla, Swabi, Tank, Tor Ghar
Ghotki, Jamshoro, Karachi, Kairpur, Sanghar, Sukkur, Tharparkar, Thatta, Karachi West
Badin, Dadu, Hyderabad, Jacobabad, Kashmore, Larkana, Matiari, Mirpurkhas, Naushahro Firoze, Shaheed Benazirabad. Kambar, Shahadkot, Shikarpur, Tando Allahyar, Tando Muhammad Khan, Umerkot, Sujawal, Karachi Central, Karachi East, Karachi South, Korangi, Malir
Ghanche, Skardu, Astore, Diamer, Ghizer, Gilgit, Hunzanagar
Muzaffarabad, Hattian, Neelum, Mirpur, Bhimber, Kotli, Poonch, Bagh, Haveli, Sudhnati
Medicinally important families and genus against skin ailments
A total number of 118 families were studied and out of them 10 families were documented in this review. Among these families, Asteraceae (8.99%) is the most commonly used family followed by Fabaceae (4.58%), Poaceae (3.73%), Laminaceae and Ranunculaceae (3.39% each), Rosaceae (3.22%), Euphorbiaceae and Solanaceae (3.05%), Polygonaceae (2.88%), Boraginaeae (2.71%), Papilionaceae and Amaranthaceae (2.37% each), Apocynaceae (2.20%), Cucurbitaceae and Malvaceae (1.86.5% each), Chenopodiaceae, Salicaceae and Liliaceae (1.69% each), Apiaceae and Brassicaceae (1.52% each), Moraceae, Scrophulariaceae and Zygophyllaceae (1.35% each) Capparidaceae, Convolvulaceae and Rutaceae (1.18% each), Cyperaceae, Rhamnaceae, Saxifragaceae and Tamaricaceae (1.01% each) and some other 87 families (30.39%).
Asteraceae holds the top position among the families used in ethno-medicines which indicates the presence of effective bioactive ingredients in the members of this family . Lamiaceae and Asteraceae are the most frequently used families in ethno-medicine . It was reported that Asteraceae family is the most diverse family found in all the habitat and regions except in Antarctica and it was not a new finding about Asteraceae family holding highest position among the traditionally important families, it was further concluded that this prevalence is due to high quantities of active secondary metabolites present in this family and also because this family includes a large number of species .
Euphorbia is the genera having highest number of species (11 ssp.) used to fight skin problems followed by Artemisia with 9 ssp., Ficus and Salix (8 ssp. each), Solanum (7 ssp.), Impatiens, Polygonum, Rumax, Saussurea, Ziziphus (6 ssp. each), Clematis, Datura, Tamarix, Vernonia (5 ssp. each), 15 genera with 4 ssp., 23 genera with 3 ssp., 72 genera with 2 ssp. and 224 genera with 1 ssp. used to combat different skin ailments.
Euphorbia taking the top place in the genera used most frequently in ethno-medicine due to the reason that it is the largest genus of family Euphorbiaceae with 1600 reported species .
Common skin diseases in Pakistan
In this review, it was found out that most of the plant species were used to treat more than 1 disease/condition of skin. Total 26 skin conditions were reviewed which were treated using ethno-medicine. Most common of them was wound healing (17.064%) followed by boil healing (8.72%), postules or pimples (5.83%), eczema (5.01%), ulcer (4.579%), burn (4.51%), Ringworm (3.889%) and scabies (3.889%).
Burn, which accounts 4.51% of the skin conditions treated traditionally in Pakistan is a serious issue globally, De Wet et al. reported increased mortality rate due to burn which has contributed to a serious health concerned issue globally. In South Africa, burn is one of the major reasons of deaths among 5–29 years individuals. Ethno-medicines have great potential to cure different kind of skin diseases [25, 137].
Tabassum and Hamdani concluded that skin conditions can be of thousand types but are categorized into nine categories based on common diseases; rashes, viral infections, bacterial infections, fungal infections, parasitic infections, pigmentation disorder, tumor and cancer, trauma and other conditions (Wrinkles, spider veins and varicose veins) . This review revealed that all these skin conditions are treated traditionally using etho-medicines.
Mabona and Vuuren reported wound healing as a most frequently treated skin condition using ethno-medicine, followed by sores or ulcers. Among the medicinal plants used to combat wounds, Erythrina genus is used most frequently in South Africa with 120 species having their space in the traditional usage against skin conditions particularly in disinfection of wounds. Traditional plants are also used to combat associated condition of wounds including inflammation, urticaria, skin allergies, acne, eczema and psoriasis. Among these associated conditions, eczema is most commonly diagnosed in South Africa and thus most frequently treated with ethno-medicines .
Trees and shrubs are used to prepare majority of herbal recipes as they are accessible round the year, followed by utilization of herbs which might be related to their easy collection methods, higher abundance and efficacy in curing ailments as compared to other life forms . Khan et al. reported shrubs and trees as most commonly used life forms in ethno-medicines due to the their availability around the year with the minimum seasonal variation . Ahmad et al. stated that herb is used in ethno-medicines due to their abundance and easy availabilty in most of the aresa of the world .
Leaves were the most commonly used plant part in ethno-medicine, this is due to the ease of processing them into a digestible paste and have less conservational issues than the collection of roots, bark, stem or the whole plant and also because leaves does not affect the life cycle of the plants , further the life form of the plant is not effected by the collection of leaves  and also due to the reason that leaves contain photosynthate which might have some medicinal value . Ayyanar and Ignacimuthu reported leaves as most frequently used plant part (accounting 50%) to prepare ethno-medicines in Kani Tribes, India .
Whole plant and roots are other frequently used plant parts probably due to bioactive components enriched in these parts. However, their excessive use is detrimental for their survival since whole plant has to be uprooted. Not only roots, even the use of more than one plant part for medicinal purpose has put these plants to extinction risk owing to damage inflicted on the plants .
Mode of preparation
Herbal preparation is made by using different plant parts like whole plant, leaves, roots, stem, fruits, flowers, barks, berries and seeds.
Different modes of preparation are used for different plants by using various parts by the native people; this study showed 23.5% ethno-preparations were used in powdered form, 22.7% paste, 16.37% decoction, 12.62% juice, 8.75% poultice, and 8% each extract and infusion and 16.25% were not mentioned in literature.
The missing information regarding mode of preparation of the ethno-medicine was also reported by Farnsworth who indicated the published studies include raw list of plants and only a small number of manuscripts reports the mode of preparation while the rest indicates the part used in treating a particular ailment .
Literature revealed that plants can be used in different ethno formulations depending upon the sort of skin disease to be treated and the type and part of plant selected to treat the disease. The ethno-formulation used for skin condition may include powder, paste, plant juice, ointment, poultice, extract, decoction or infusion [42, 43].
Decoction and infusion are frequently used in ethno-medicine due to the ease of preparation and because water is used as a solvent in these formulations, which is easily available . Felhaber reported that ethno-medicines can be given orally or applied topically. Though both the routes can be used but topical application is common as well as effective as it ensures direct contact of active constituents of plant with the site of action (skin) and also because it gives a quick relief .
Medicinal plants are used in combination with other medicinal plants, with vegetable oils (mustard oil, apricot oil etc.) and/or with the nutrients (milk, ghee etc.). People of Pakistan still rely on synergistic interactions of plants and supportive components like oil and milk to treat skin diseases.
These supplement ingredients may be used to enhance the effect of the herbal preparations or are simply used to make the preparations palatable. And on the other hand they improve the healing conditions; however, the exact role of these materials in curing the diseases is not clearly known .
A number of plant combinations used to treat skin conditions have been reported. The synergistic interaction of medicinal plants have been used since antiquity. Mabona and Van Vuuren reported that medicinal plants are used alone as well as in combination with other plants without any adequate validation of the combination. Plant species like Acorus calamus, Cyathula natalensis, Cyanella lutea, Hypoxis latifolia, Momordica foetida, Pittosporum viridiflorum and Vernonia natalensis have effects on skin when used in combination with other plants but if used alone, they do not have any dermatological effects; they may have potential to treat the additional symptoms associated with skin conditions like fever in skin infection .
Combination of ethno plants used for skin conditions
Mode of preperation
Cynodon dactylon (L.) + Curcuma longa L.
Grind along with Curcuma longa and rice
To stop bleeding from wounds, scabies, fungal infections, leprosy, wound healing, pimples, eczema, anti-septic, itching, small pox
Melia azedarach L. + Phyllanthus emblica L. + Terminalia chebula Retz.
Leaves are ground in water along with black pepper. Tablet are prepared from paste of dry friut of Melia azadarach, Phyllanthus emblica, and Terminalia chebula
Skin infection, wound healing and leprosy, scabies, pustules, pimples, boils and other skin diseases, allergy and itching, eczema and measles, boil, allergy, leucoderma, Cutaneous infections, Germicidal
Aloe vera (L.) + Citrus limon (L.) Burm. f.
Pulp of aloe along with 2–3 drops of lemon and rose extract is also used
Wound healing, chronic, dermatitis and radiation burn treatment, cuts, burns, eczema, sunburn, dermatitis, acne, freckles, pimples and boils, ulcer
Aloe barbadensis Mill. + Curcuma longa L. Aloe barbadensis Mill. + Cichorium intybus L.
Pulp of the leaf of Aloe is added with powdered Curcuma longa for dermal use on wounds. Pulp of the leaf of Aloe and chicory (Cichorium intybus) are soaked in water at night
Skin beauty, skin disease, wound healing, burn, eruption, boils, itchy skin
Cyperus rotundus L. + Curcuma longa L.
Roots of Cyperus rotundus L. along with turmeric and curd are made into a paste
leprosy, Skin diseases, pruritus, eczema, wound healing, pimples, acne
Xanthium stromarium Linn. + Calotropis procera (Aiton) R. Br
Fresh leaves of Xanthium stromarium Linn. are crushed with the leaves of Calotropis procera
leprosy, and purities, wound healing, Smallpox, eczema, Ulcers, boils
Canabis sativa Linn + Cassia fistula Schimp.ex.Oliv
The seed of Cassia fistula and one gram leaves of Cannabis sativa are taken along a cup of milk
Leprosy, Wound healing, Measles, Dressing of wounds and sores, Scabies
Clematis orientalis L. + PineWolf
The leaf paste used with resin of Pine on wounds to cure promptly
Antiseptic, pimples, antiseptic, burns, Eczema, Wound healing, Syphilis
Chenopodium album L. + Solanum surattense Burm. f.
Decoction of Chenopodium albumis is prepared with Solanum suttattense
Ulcer, Measles and other skin diseases
Fragaria nubicola (Hook. f.) nubicola (Hook. f.) + Berberis lyceum Royle
Powder of leaves and roots is mixed Berberis lycium
Plants used in combination with oils
Acacia Arabica (Lam.) Willd.
F, L, S, Bk
mixed with oil And applied
Wound healing, eczema and other skin diseases
Aconitum heterophyllum Wall. ex Royle
The dried pulverized roots are mixed with butter oil
Abscess, boils and other skin diseases
adhatoda zeylanica Medik
Bhaikar, Barg-e-baansa and Arrusa
Ash of leaves is mixed with mustard oil and externally
Pustules and pimples
Allium cepa L.
Ghashoo, Tukhm peyaz, onion
S, L, bk, bu
One or two scales are warmed in mustard oil and crushed. This paste is applied twice a day for 2–3 days
Wound healing, Eruption, boils, Chicken pox, Pimples, Skin infections, gonorrhea and other skin diseases
Cleome viscosa Linn.
Leaves are coated with sesame oil and warmed over fire, which are applied over pain and inflammation of the boils
Calotropis procera (Willd.) R. Br.
Dasi ak, Milk weed, Akk, Spalmaka, wallow-wort, Sodom apple, Dead Sea apple
S, Bk, L, Sd, R, Ft, WP
Latex is mixed with castor oil and applied on skin. Flowers are put in oil applied to wounds to cure them. Roots are powdered, mixed with “desi ghee” and pasted on points of leprosy
Leprosy, wound healing, abscess, ringworm, eczema, pustules and pimples, eruptions, syphilis, boils, ulcer, burn, dermatitis, scabies, skin infection
Lawsonia alba Lam.
Leaves are mixed with the mustard oil and made into paste
Leukoderma, athlete foot
Polygonum tataricum L.
The flour is mixed with apricot oil in boiling water; paste is formed and applied to skin overnight.
Potentilla nepalensis Hook.
The leaves are boiled in milk and applied/powder (ashes) is being applied with oil
Boil healing, burns and bruises
Sporobolus ioclados (Trin.)
Mixed with oil and applied
Plants used in combination with nutrients
Ajuga bracteosa Wall. ex Benth
Khawaja booti,, Kauri Booti
L, R, WP
Macerate with yogurt is applied
Skin infections, Wound healing, pimples, measles, Boils
Zizipnus manurithiana Lam.
Leaves are poused into a paste mixed with gurh and then applied as a poultice
Bergenia ciliate A. Br. ex Engl.
Chata pana (Zakhm-e-hayat)
R, Fl, L, Bk, Sd, Rh
The powder of roots is mixed with Desi ghee
Wound healing, Sun burn, washing ulcers, infection, pimples and other skin diseases
Boerhaavia diffusa L.
Roots are crushed, boiled in milk and poultice is made
Citrus medica Linn.
L, Sd, Lt
Fruit extract is mixed with honey and fresh milk to make its paste
Itching, inflammation, Pimples
Convolvolus arvensis Linn
Heran Kari, Heran-paddi
P, Sh, L, F, R, S, Fl
Plant is ground along with black pepper and eaten
Wound healing, boils, scabies, ringworm
Cynoglossum denticulatum DC
Root is powdered and mixed with milk
Pustules and pimples
Ficus variegata Wall. Ex Roxb
Paste prepared from fresh milky juice of plant mixed milk
Boils, infected skin
Grewia tenax (Forssk.) Fiori
White spurry, Kaankeh, Wingo
The ash of the leaves is mixed with butter to make poultice
Abscess and wound healing, boils
Jurinea macrocephala Benth. ex Hook.f.
Decoction of roots is mixed with butter
Mallotus philippensis (Lam.) Müll. Arg.
Red powder of fruit is mixed with butter
Otostegia limbata (Benth.) Boiss
Kori booi, Spin Azghay, Chiti, Chittakanda, Ghawareja
Dried leaves are ground and mixed in butter to form a paste. Leaves are dried, ground and powder is mixed with honey. A table spoon is taken once a day
Wound healing and bruises
Pinus roxburghii Sarg
AP, Sh, G, Bk, Rs
Young shoot is fried on pan and milk is added
Wounds, sores, burns, boils and ulcers, measles
Pinus wallichiana A. B. Jacks
Cheenh, Biar, Kail
Resin admixture with honey
Wound healing, antiseptic, Gonorrhea, abscess, for burning sensation, ulcer
Rumex nepalensis Spreng
L, S, R
Dried leaf powder is mixed with butter (ghee)
Wound healing and anti-allergy, boil
Stellaria media (Linn.)
Khashkhash boti, Losdhi, Salooni booti
WP, Sd, L
Seed powder with milk is given to children to cure skin infection and allergy
Wound healing, infections, allergy, itching-skin condition, eczema, ulcers, boils, abscesses, rashes, burns and irritations
Viola serpens Wall
The whole plant is taken and boiled in milk till it become gelatinous. Bandage is made from it and used as poultice
Wound healing, eczema
Endangered species of Pakistan
Aconitum chasmanthum Stapf ex Holmes
I. Over harvesting and loss of habitat due to construction of high altitude roads and avalanch
II. Regeneration of the species is hampered due to unsustainable collection of tubers and roots
I. Intensive studies on the population trend, reproductive biology and propagation techniques should be carried out to support conservation action programs
II. Habitat managment and sustainable collection practice
III. Active in situ conservation may be undertaken in protected areas
IV.Surveying and monitoring is needed across the known range of occurrence to ascertain the status of wild subpopulations
http://www.iucnredlist.org/details/50126558/0 (assessed on 25.12.2016)
Aconitum heterophyllum Wall. ex Royle
I. Loss of habitat due to road construction and unsustainable collection from wild
II. Large scale collection
III. This species is under severe threat due to illegal collection and marketing
I. Intensive studies on the population trend, reproductive biology and propagation techniques should be carried out to support conservation action programs
II. Habitat managment and sustainable collection practice
III. Active in situ conservation may be undertaken in protected areas
IV. Surveying and monitoring is needed across the known range of occurrence to ascertain the status of wild subpopulations
http://www.iucnredlist.org/details/50126560/0 (assessed on 25.12.2016)
Aconitum violaceum Jacquem. ex Stapf
I. Loss of habitat due to agriculture and unsustainable
II. Collection from wild
I. Habitat loss and over exploitation
II. It needs immediate attention in habitat management and sustainable collection practices
III. Active in situ conservation should be undertaken in protected areas
IV. Surveying and monitoring is also needed throughout the known historic range of the taxon to ascertain the status of all recorded subpopulations
V. Intensive studies on population trend, reproductive biology and propagation techniques need to be carried out to support conservation action programs
http://www.iucnredlist.org/details/50126560 (assessed on 25.12.2016)
Betula utilis D. Don
I. Over exploitation as it is a high value medicinal plant
II. In the Mankial Valley Hindukush Range, Pakistan, 85% of the population has decreased
Harvesting must be sustainable to ensure the survival of this species
http://www.iucnredlist.org/details/194535/0 (assessed on 25.12.2016)
Cedrus deodara (Roxb. ex D. Don) G. Don
I. Intensive logging (legal and illegal)
II. Deforestation and conversion of forests for agriculture may also pose local threats in some parts of Pakistan and India
Known from several protected areas across its range
http://www.iucnredlist.org/details/42304/0 (assessed on 25.12.2016)
Commiphora wightii (Arn.) Bhandari
I. Unsustainable collection of multiple parts, high volume trade and loss of habitat
II. Grazing and browsing by sheep and goats
III. Collection of branches as fuel wood during the rainy season, scarcity or festive times
IV. This species demonstrates one of the most generic problems of conservation
V. Overexploitation, a narrow extent of occurrence, small area of occupancy, severe fragmentation of populations, very low regeneration and invasion of alien species mean that C. wightii is facing a high extinction risk
I. Biotic pressure should be regulated
II. Standard and better gum extraction technique could minimize the mortality rate of the species (Dixit and Rao 2000)
III. Ex situ conservation and multiplication through micro and macro propagation technique
IV. Some attention and efforts have been brought into the system by identifying and documenting more than 100 forest areas (MPCAs)
http://www.iucnredlist.org/details/31231/0 (assessed on 25.12.2016)
Schrenk ex C.A. Mey.
Over harvesting should be investigated
Monitoring of wild harvesting is recommended to better understand how this is affecting population size
http://www.iucnredlist.org/details/201664/0 (assessed on 25.12.2016)
Gentiana kurroo Royle
I. Loss of habitat and unregulated harvesting. Due to road construction and agricultural invasion
II. Over grazing and human settlements
III. Climate change, in terms of temperature and rainfall, has severe impacts on the population and habitat
I. It needs immediate attention in terms of trade regulation, habitat management and sustainable collection practice
II. Ex situ conservation and cultivation may help to reduce the pressure on wild population
http://www.iucnredlist.org/details/50126594/0 (assessed on 25.12.2016)
Juniperus excels M. Bieb.
No specific range wide threats have been identified for this species; over exploitation and habitat degradation and conversion may be localised problems
This species is known from several protected areas throughout its range
http://www.iucnredlist.org/details/42232/0 (assessed on 25.12.2016)
Juniperus squamata Lamb.
This species is recorded from many protected areas
http://www.iucnredlist.org/details/42254/0 (assessed on 25.12.2016)
Pinus gerardiana Wall. Ex D. Don
I. Conversion for pine forests for agricultural use, increasing the degree of fragmentation, and overgrazing that prevents natural regeneration
II. Over harvesting of seed cones contributes to poor regeneration
III. Over exploitation for firewood
I. In Afghanistan, plantations have been established to supply the seeds
II. In other parts of its range P. gerardiana forests are included within protected areas
III. A combination of reafforestation programmes coupled with sustainable use strategies are needed before this species declines sufficiently to become eligible for a threatened category
http://www.iucnredlist.org/details/34189/0 (assessed on 25.12.2016)
Pinus roxburghii Sarg.
While forest destruction and logging have reduced the area of occupancy (AOO) of P. roxburghii, it is still covering extensive areas (an estimated 0.87 million ha in India alone) and is therefore not considered to be threatened with extinction. Improved methods of resin tapping have decreased the risk of trees dying prematurely
This species occurs in some protected areas
http://www.iucnredlist.org/details/42412/0 (assessed on 25.12.2016)
Pinus wallichiana A.B. Jacks.
Potentially, over-exploitation could negatively impact the population, but the species is too common and wide-spread for this to have serious consequences other than locally
This species occurs in several protected areas
http://www.iucnredlist.org/details/42427/0 (assessed on 25.12.2016)
Using the part like roots, rhizomes or bulbs could be a severe threat for reproduction of medicinal plants of the area. The plants collected by using these methods, especially those propagated through rhizome, bulb or corm, need sustainable utilization and conservation strategies. Un-sustainability of harvesting of herbaceous roots is well recognized by conservationists and termed such medicinal plants as highly threatened . Uprooting a plants is the most detrimental method of plant collection, if the roots are not removed completely it can also result in destruction by decreasing water upset and increasing susceptibility of fungal infection. Commercialization is the major cause of extinction of medicinal plants in South Africa which demands over harvesting and thus has taken natural medicinal resources to near extinction .
Shanwari suggested to establish protocols to interpret the pattern of plant growth and to accelerate the knowledge about propagation of medicinal plants and avoiding harvesting of wild species in order to save endangered species .
Aconitum chasmanthus, A. heterophyllumand, A. violaceum, which are native to Pakistan, India and Nepal [46–48], are harvested for their tubers which constitute Ayurveda drug and for this reason whole plants are uprooted. In 2003 in a CAMP workshop organized at India (Shimla), experts agreed that 80% of the wild population of Aconitum chasmanthus had declined and therefore it is assessed as “critically endangered species”, 70% of that of A. heterophyllum had declined and it is assessed as “endangered” while 40% decline of the population of A. violaceum has made it a “vulnerable” specie to become endangered. This decline is over a decade but the situation has not improved and therefore the status id still valid . It was observed in a survey in India that collection amount of A. heterophyllum has dropped down from 200 g per person per day to 70–100 g per person per day in 5 years . Moreover, illegal collection of this specie has let it threatened .
Reddy et al. reported that oleo-gum resin tapped from the stems of Commiphora wightii constitutes the well-known Ayurvedic drug “Guggul” which is consumed in high volumes by the herbal industries of Sub-continent. Field observations over the last several decades have confirmed a severe decline in its wild population, as the shrubs tapped for oleo-gum resin die within 2–3 years. Over the past 84 years (three generation lengths) there has been a decline of more than 80% in the wild population as a result of habitat loss and degradation, coupled with unregulated harvesting and tapping of oleo-gum resin. This species is therefore assessed as Critically Endangered . Soni identified a number of relevant activities within the study area under the theme ‘Guggal Bachao Abhiyan’ (Save Guggal Movement). These were conducted through the close co-operation of the village level communities, who depend on local biodiversity for their livelihoods in the Aravali Hills of Rajasthan .
Gentiana kurroo is mainly collected from the wild and there is no information regarding its cultivation. Hence, the species is under severe threat of extinction. This assessment was primarily based on the very limited reported presence of the species in wild and the high demand and prices for the dried roots of this plant. The wild population in IndoPak region is inferred to have declined by 80% in a 10 years time period. The recent CAMP assessment also agrees with the trend of population decline of more than 80% in India. Therefore, the species is assessed as Critically Endangered [54, 55].
Commercially available important plants
List of some commercially available medicinal plants used in Pakistan
Calotropis procera (Willd.) R. Br.
Hamdard laboratories Waqf Pakistan
Ammonium chloride68.070000 mg/Tab
Calotropis procera (Ait.) R. Br.11.345000 mg/Tab
Ferula assafoetida Linn.5.627000 mg/Tab
Lake salt68.070000 mg/Tab
Myrtus caryophyllus Spreng. 84.952000 mg/Tab
Piper nigrum Linn.34.035000 mg/Tab
Potassium Carbonate11.345000 mg/Tab
Sanchal Salt84.952000 mg/Tab
Sodii biboras11.345000 mg/Tab
Zingiber officinale Roscoe 34.035000 mg/Tab
Twice a day
Berberis lyceum Royle
QARSHI INDUSTRIES (PVT) LTD
Ammonium chloride 30.000000 mg/10 ml
Berberis aristata DC. 200.000000 mg/10 ml
Cichorium intybus Linn. 100.000000 mg/10 ml
Citrus limonum Risso (Oil) 10.000000 mg/10 ml
Citrus limonum Risso (Bark) 300.000000 mg/10 ml
Ferrous ammonium sulphate 50.000000 mg/10 ml
Jawahar mohra 10.000000 mg/10 ml
Nelumbium speciosum Willd. 100.000000 mg/10 ml
Rosa damascena Miller 100.000000 mg/10 ml
Santalum album Linn. 26.660000 mg/10 ml
Strychnos nux-vomica Linn. (Extract) 10.000000 mg/10 ml
Vitis vinifera Linn. 200.000000 mg/10 ml
Preservatives 0.000000 Q.S
Saccharum Base 0.000000 Q.S
Twice a day
Achyranthes aspera L.
QARSHI INDUSTRIES (PVT) LTD
Achyranthes aspera Linn.312.000000 mg/10 ml
Adhatoda vasica Nees125.000000 mg/10 ml
Ephedra gerardiana Wall. ex Stapf125.000000 mg/10 ml
Glycyrrhiza glabra Linn.125.000000 mg/10 ml
Khashkhash musaffa125.000000 mg/10 ml
Mentha piperita Linn. (Extract) 2.500000 mg/10 ml
Pistacia integerrima J. L. Stewart ex Brandis125.000000 mg/10 ml
6 times a day
Riccinus communis L.
Hamdard laboratories Waqf Pakistan
Celastrus paniculatus Willd. (Oil) 0.500000 g/3 g
Cinnamomum cassia Blume (Oil) 0.100000 g/3 g
Ricinus communis Linn. (Oil) 1.500000 g/3 g
Sea Salt0.320000 g/3 g
Styrax benzoin Dryander 0.160000 g/3 g
Wax0.320000 g/3 g
3 g once daily
Carthamus tinctorious L.
Hamdard laboratories Waqf Pakistan
Ammonium chloride 15.500000 mg/500 mg,
Black salt 15.500000 mg/500 mg
Carthamus tinctorius Linn. 15.500000 mg/500 mg
Carum carvi Linn. 15.500000 mg/500 mg
Cinnamomum cassia Blume 15.500000 mg/500 mg
Cinnamomum malabathrum Batka 15.500000 mg/500 mg
Cuminum cyminum Linn. 15.500000 mg/500 mg
Cuscuta reflexa Roxb. 15.500000 mg/500 mg
Foeniculum vulgare Miller 15.500000 mg/500 mg
Lake salt 30.750000 mg/500 mg
Piper nigrum Linn. (White) 15.500000 mg/500 mg
Piper nigrum Linn. (Black) 15.500000 mg/500 mg
Rock Salt 185.000000 mg/500 mg
Valeriana officinalis Linn. 15.500000 mg/500 mg
Zingiber officinale Roscoe 15.500000 mg/500 mg
2 tab once daily
Solanum nigrum L.
QARSHI INDUSTRIES (PVT) LTD
Acacia arabica (Lam.) Willd. 62.500000 mg/10 ml
Achillea millefolium Linn. 62.500000 mg/10 ml
Adiantum capillus-veneris Linn 62.500000 mg/10 ml
Cichorium endivia Linn. 62.500000 mg/10 ml
Ficus bengalensis Linn. 62.500000 mg/10 ml
Fumaria offcinalis 62.500000 mg/10 ml
Gendarussa vulgaris 62.500000 mg/10 ml
Iron Compound 50.000000 mg/10 ml
Juniperus communis Linn. var. saxatilis Pall. 62.500000 mg/10 ml
Melia azadarach Linn. 62.500000 mg/10 ml
Nepeta ruderalis Ham. 62.500000 mg/10 ml
Pimpinella anisum Linn. 62.500000 mg/10 ml
Rubia cordifolia Linn. 62.500000 mg/10 ml
Solanum nigrum Linn. 62.500000 mg/10 ml
2 teaspoon twice a day
Aloe barbadensis Mill.
Hamdard laboratories Waqf Pakistan
Aloe barbadensis Mill. 1.000000 g/100 ml
5 teaspoon thrice a day
Ficus carica Linn.
Hamdard laboratories Waqf Pakistan
Acacia arabica (Lam.) Willd. 23.520000 mg/Tab
Ficus caricaLinn. 23.520000 mg/Tab
Melia azadarach Linn. (Peel) 23.520000 mg/Tab
Melia azadirachta Linn (Leaves) 23.520000 mg/Tab
Melia azadirachta Linn (Bark) 23.520000 mg/Tab
Psoralea corylifolia Linn. 23.520000 mg/Tab
3 tab thrice a day
Fumaria indica Linn
Hamdard laboratories Waqf Pakistan
Cassia angustifolia Vahl. 0.075000 g/6 g
Emblica officinalis Linn. (Dry) 0.150000 g/6 g
Fumaria indica (Haussk) Pugsley (Leaves) 0.375000 g/6 g
Rosa damascene Miller 0.045000 g/6 g
Terminalia chebula Retz. 0.150000 g/6 g
Sweetening agent and preservatives 0.000000 Q.S
6–12 g daily
Datura stramonium L.
Hamdard laboratories Waqf Pakistan
Asphaltum 3.330000 g/Tab
Bombax ceiba Linn. 16.660000 g/Tab
Centaurea behenLinn. 8.330000 g/Tab
Corylus avellana Linn. 2.660000 g/Tab
Datura stramonium Linn. 2.660000 g/Tab
Hyoscyamus niger Linn. 2.660000 g/Tab
Juglans regia Linn. 2.660000 g/Tab
Lactuca scariola Linn. 2.660000 g/Tab
Lagenaria vulgaris Ser 2.660000 g/Tab
Myristica fragrans Houtt. (Seeds (nutmeg)) 1.330000 g/Tab
Myristica fragrans Houtt. (Seeds (mace)) 1.330000 g/Tab
Papaver somniferum Linn. 2.660000 g/Tab
Pinus gerardiana Wall ex Lam. 2.660000 g/Tab
Pistacia vera Linn. 2.660000 g/Tab
Prunus amygdalus Batsch. 2.660000 g/Tab
1–2 tab once daily
Worth and number of herbal industries is increasing day by day in Pakistan due to the trust of people on traditional medicines .
Ethno-medicines has a vital role in the industrialization . Vivienne et al. stated commercial importance of medicinal plants in South Africa and reported 11 species of medicinal plants that are imported from India and other countries including Cinnamommum camphora. They also concluded that the size of the regional market of medicinal plants can be assessed by knowing the number of species traded. Commercial utilization of the medicinal plant is directly related to the degree of extinction .
The review revealed that many of the important information like ethno preparation, habit and part used, of many important medicinal plants were not available in previous articles which can be due to the lack of interest of local youth to acquire the traditional knowledge from the ancestors and thus provision of incomplete information to the previous articles, further ethno-pharmacological research should be carried out to save the traditional knowledge and to take it to the light of science.
Medicinal plants in Pakistan contain great variety which can be used against a large number of skin ailments. Leaves, whole plant and roots are the most widely used parts in different ethno-medicinal preparations. Whole plant and root harvesting are the destructive type of techniques, it is important to protect the medicinal plants from exploitation. Although in Pakistan there is a strong traditional background supporting the use of these ethno-medicines against skin ailments but detailed ethno-pharmacological studies are not enough to support the folk claim. Majority of the studies have not documented other information regarding mode of preparation and dose of ethno-medicine. Therefore it is necessary to carry out a comprehensive study on ethno-pharmacology in Pakistan. It is important as the folk knowledge supplements a scientific investigations and penetrations with the primary information. Very limited number of studies provides toxic profile of these medicinal plants, toxicity studies should be carried out for these medicinal plants in animal system to establish a safe dose range.
More pharmacological studies (in vitro and in vivo) should be carried out on medicinal plants of Pakistan that are relatively unexplored or less explored. Mostly, the extracts were tested against different pathogens, for wound healing properties and for other skin conditions. However, very few classes of secondary metabolites and pure isolated components were tested. Therefore, it is imperative to conduct detailed phytochemical studies for the isolation of novel compounds.
A gave basic concept of the paper and reviewed and drafted the manuscript, AS, HA, WY, HR, also collected and analyzed data and drafted the manuscript. IAB and AMA collected papers using facilities of their university and also helped in writing paper. All authors read and approved the final manuscript.
The authors extend their appreciation to the deanship scientific research at King Saud university for funding this research through # (RG-1439-002).
The authors declare that they have no competing interests.
Availability of data and materials
All data generated and analyzed in this study is has been taken from the free excess sources while those which were not available online were taken by authors from king Saud University.
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